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Tag: "chronic" at biology news

Canada approves marijuana-based pain spray

...ted that 50 per cent of people with MS suffer from chronic neuropathic pain. 2,3,4 The most common descriptions of neuropathic pain are of freezing, cold or burning sensations usually of the limbs and most often of the lower extremities.5 Many individuals with neuropathic pain respond inadequately to current...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...erceptin for metastatic breast cancer, Gleevec for chronic myeloid leukemia and Erbitux for metastatic colorectal cancer. "FDA's efforts will bring us one step closer to 'personalizing' medical treatment," explained Janet Woodcock, M.D., Acting Deputy Commissioner for Operations, FDA. "This new technology w...

Mouse gene shows new mechanism behind cardiac infarction in man

...pathogenesis of atherosclerosis and of a number of chronic inflammatory diseases. The new finding will spur further research into the relationship between the protein and cardiac infarction. Hopefully it will offer a new therapeutic technique for the treatment of atherosclerosis and thus reduce the risk of c...

A little stress gives beneficial oomph! to immune system

...acute stressors, other researchers have found that chronic stress may substantively weaken the immune system. Leukocytes are always present in the body, but most remain dormant until an immune response is activated by wounding or infection or until the brain identifies a stressful situation. When that happe...

Two chemicals boost immune cells' ability to fight HIV without gene therapy

...fection's early phase, but stop once HIV becomes a chronic condition," explained Rita Effros, Ph.D., Plott En...l for a wide spectrum of degenerative diseases and chronic conditions in which cellular aging plays a role. "I'm really excited by our findings. This progress...

Molecular thermometers on skin cells detect heat and camphor

... are currently under investigation for alleviating chronic pain target the action of a protein called TRPV1 (VR1), which is similar to TRPV3. Molecular Thermometers TRPV3 and TRPV1 are both proteins that belong to a class of molecules known as "transient receptor potential" channels. There are at least six...

Prescription Drug Patches Gaining Ground, Tackling New Therapies

... quietly gaining market share for the treatment of chronic conditions such as angina, hypertension and HRT, the technology is set to make further inroads as transdermal patches for a host of new conditions wind their way through the development and clinical trial process. Growth in demand for prescription d...

Researchers find gene that may be at root of potato blight

...e United States and other developed countries, the chronic use of chemicals to manage late blight reduces the profit margins of farmers and is not always successful. "In developing countries, late blight also affects subsistence potato production," he continued. For example, a late blight breakout in 2003 b...

UCLA study assesses cost-effectiveness of Hepatitis B drugs

...ss of five competing drug treatment strategies for chronic hepatitis B: 1) No treatment at all 2) Interferon ...cepted by society and many insurers for treating a chronic condition like hepatitis B is roughly $50,000 or less per quality-adjusted life-year gained, which i...

Natural Killers Could Lead to New Hepatitis Treatments

...ant inflammatory role, particularly in the case of chronic hepatitis,?he said. “If that is the case, we speculate that it may be possible to manipulate the NKT cell, perhaps by interfering with CXCR6 function, to ameliorate the inflammatory process,?he said. Still unknown, said Littman, is which antigens al...

B cells are required for development of epithelial cancer associated with chronic inflammation

...ortant regulators of premalignancy associated with chronic inflammation. The results suggest that drugs targe...f cancer in tissues identified as "at risk" due to chronic inflammation. Previous studies have implicated an interaction between adaptive immune cells, like B...

Active Vaccine Prevents Mice From Developing Prion Disease

...ses -- which include scrapie, mad cow disease, and chronic wasting disease -- is on the horizon, many researc...mple, there is ever a more significant outbreak of chronic wasting disease and if this disease were found to be transmissible to humans, then we would need a v...

Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot

...yo Clinic researchers have found that the cause of chronic sinus infections lies in the nasal mucus -- the sn...hat has been thought worldwide about the origin of chronic sinus infection: that inflammatory cells break down, releasing toxic proteins into the diseased airw...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

... his colleagues reveals a second mechanism whereby chronic dopamine affects the brain, perhaps indefinitely. The Duke team's previous work suggested that the regulatory protein beta-arrestin 2, normally involved in desensitization of receptor signals, is required for normal dopamine-related behavior. They a...

Cancer drug slows poxvirus in mice

...member, Abl, causes a rare form of cancer known as chronic myelogenous leukemia (CML). Gleevec inhibits Abl-family tyrosine kinases and has proved very useful in treating CML. To learn whether Gleevec could prevent or lessen vaccinia's ability to spread in a living organism, the researchers treated mice wit...

FDA Approves New Treatment for Chronic Hepatitis B

...ir) tablets and oral solution for the treatment of chronic hepatitis B in adults. Chronic hepatitis B is a se...the HBV virus. Baraclude slows the progression of chronic hepatitis B by interfering with viral reproduction. FDA based its approval of Baraclude on the resu...

Stem cell treatment improves mobility after spinal cord injury

...ng the first few weeks of the injury. In turn, the chronic period begins after a few months. It is anticipate...Although the oligodendrocyte cells survived in the chronic injury sites, they could not form myelin because the space surrounding neuron cells had been filled ...

Immune system's distress signal tells bacteria when to strike back

...al flora," people with no real infection develop a chronic disease. The battles between pathogens and their hosts have been going on for millions of years, Alverdy said, with each side constantly devising novel measures, countermeasures, and counter-countermeasures, including sophisticated mutual espionage....

Fat's fate depends on its source

...sm, offering an alternative mechanism for fighting chronic diseases, including obesity, diabetes, and heart disease, Semenkovich said. The researchers inactivated fatty-acid synthase, an enzyme that generates new fat from carbohydrates, in the livers of mice. When fed a diet completely lacking fat, the mice...

Identification of specific genes predicts which patients will respond to Hepatitis C treatment

...t of genes that can predict whether a patient with chronic Hepatitis C will be able to respond to current tre...ght be able to improve treatment responses to this chronic disease." "This information is helpful for patients because it's one more piece of evidence that we...

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