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Tag: "cholesterol" at biology news

Bone and cartilage growth to blame for heart valve disease

...y an inflammatory process likely triggered by high cholesterol that stimulates certain cells to reprogram into bone cells in the aortic valve and cartilage cells in the mitral valve, says principal investigator Nalini Rajamannan, MD, newly appointed director of the Center for Heart Valve Disease in the Bluhm Car...

Dogs keep dying: Many owners unaware of toxic dog food

...oisoned dogs. Aflatoxin curtails the production of cholesterol and many proteins that profoundly affect blood clotting. A minimum screening profile should assess the liver enzyme ALT to detect damage to the liver, serum cholesterol, total bilirubin concentration and the activity of the anticoagulant proteins ant...

Nearly half of people who need cholesterol treatment don't get it

Even though treatment for cholesterol disorders can reduce the risk of heart and blood v...e American Heart Association. "Under-treatment of cholesterol disorders is a major public health challenge," said lead author David Goff Jr., M.D., Ph.D. "In our ...

Worm hormone discovery may aid fight against parasitic disease

... such as when food is scarce. Dr. Mangelsdorf said cholesterol and other signals derived from the worm's food source are required to launch the series of biochemical events leading to the production of the hormonal ligand and continued development. Without these environmental signals and the ligand to activate D...

Measuring artery repair cells could become new heart disease test

...rt attack, and they could become as routine as the cholesterol and lipid tests cardiologists now commonly use. Pa...hile risk factors such as poor diet, smoking, high cholesterol levels and inactivity are important in the development of atherosclerosis --the disease progresses a...

Intensive statin therapy may partially reverse plaque build-up in arteries

...onstrates, for the first time, that very intensive cholesterol lowering with a statin drug can regress (partially...a study using statin drugs, the most commonly used cholesterol lowering treatment. Previous research had indicated that intensive statin therapy could prevent the ...

'Nano-keys' bind cell receptors and trigger allergic reactions

...ies for allergies and other immune responses, high cholesterol and perhaps viral infections. By understanding a membrane's role in cell function, she explained that these nano-keys could interfere with responses via the membrane interactions, rather than just targeting proteins to block responses. This could le...

Cholesterol gets 'thumbs up' for role in digit development

...ingers and toes, she probably doesn't realize that cholesterol may be to thank for baby's complete set of 20 digits. Although cholesterol has a bad rap as the sticky, fatty substance responsible for clogging arteries, Vanderbilt Universit...

Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin

...as also been demonstrated that pectin lowers serum cholesterol levels.) While not the breakthrough that will allow immediate manipulation of total pectin biosynthesis, it is, one of the researchers involved said, "the first word of the Rosetta Stone that will show us the blueprint for pectin biosynthesis." The ...

Ernst Mayr's theory illustrated in genetic epidemiology studies

...enes physically interact. Both play a role in high cholesterol that can lead to CAD, but in most human population...arent importance of these two genes in influencing cholesterol levels can be totally reversed. Such alterations, Templeton said, are the fundamental basis of gene...

'Bad' enzymes may wear white hats after stroke

...se. Statins are a class of drugs that reduce serum cholesterol levels. "I did some work suggesting that statins might counteract the hemorrhagic effect of tPA and might someday be used as an adjuvant therapy with tPA," she said. "I also did some work with beta amyloid, the protein implicated in Alzheimer's dise...

Phenolic compounds may explain Mediterranean diet benefits

... study participants (5 men, 16 women) who had high cholesterol levels, but were otherwise apparently healthy. The functioning of the endothelium (the inner lining) of small blood vessels of the fingers (instead of "in the arms") of participants and the concentrations of certain components in blood serum, includi...

Recreating 'Flowers for Algernon' with a happy ending

..., UCLA scientists used statins, a popular class of cholesterol drugs, to reverse the attention deficits linked to...uffed with a million dollars." Statin drugs lower cholesterol by blocking the effects of certain fats. Because Ras requires fat to function, less fat results in ...

Researchers show how air pollution can cause heart disease

...l and high-fat diet mice, PM2.5 exposure increased cholesterol levels, which are thought to exacerbate plaque buildup. Though findings for increased plaque among mice eating normal diets were not statistically significant, Dr. Chen believes that future research on larger numbers of animals will solidify the tr...

Baby's genes affect mom's cholesterol levels

...proteins called apolipoproteins and lipids such as cholesterol and triglycerides." explains Descamps. "Lipoprotei... influence the concentrations of triglycerides and cholesterol in the general population. They found that when these polymorphisms were present in the babies, thei...

New gene scanning technology marks a major advance in disease research

...ment of Health, studied a gene which affects blood cholesterol levels. In analyses of nearly 10,000 middle-aged i...h very high cholesterol, some with moderately high cholesterol and some with no effect. This is the first time that it has been possible to find out whether there...

Beyond genes: Lipid helps cell wall protein fold into proper shape

...short. Phospholipids, unlike their fatty acid and cholesterol cousins, include a phosphate group that spurs them to form a bilayer with water-friendly outer layers sandwiching an impermeable water-unfriendly inner layer that defines the outer surface of cells. Transport of nutrients and waste material across th...

New type of rejection blocker protects kidneys after transplant

...ients in all treatment groups had comparable total cholesterol levels and comparable blood pressure levels at 12 months. However, 53 percent of cyclosporine patients required lipid-lowering medications compared to 32-36 percent of belatacept patients. More than half of cyclosporine treated patients needed anti-h...

Fat's fate depends on its source

...d to burn fat normally and to maintain glucose and cholesterol levels within the normal range. "These findings u... fatty acid synthesis regulate glucose, lipid, and cholesterol metabolism by activating distinct pools of PPARa in the liver. Further study is required to elucidat...

Excess liver gene protects against high-fat diet

...ed a diet high in fat, remained free from the high cholesterol and blood vessel plaques exhibited by animals with...erences among them in their susceptibility to high cholesterol and heart disease in a manner dependent on diet. Furthermore, drugs that modulate LXRa activity may ...

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