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Tag: "cholesterol" at biology news

Hormone helps mice 'hibernate,' survive starvation

...neficial effects, such as lowering blood pressure, cholesterol and glucose levels in the blood, Dr. Kliewer is interested in understanding how FGF21 impacts these processes. “We want to see if we can get some benefits of eating less without actually eating less,” he said. Manipulating the PPAR-alpha-FGF21 ...

In mice, drug protects against diabetes and atherosclerosis

...animals are severely obese or have high amounts of cholesterol and consume dangerously fatty foods. Use of the co...he aP2 signals encourage macrophages to load up on cholesterol and become "foam cells" that adhere to artery walls, creating dangerous plaques that eventually may ...

Study finds mix of disease processes at work in brains of most people with dementia

...or cardiovascular disease such as control of blood cholesterol levels and hypertension.” NIA is conducting clinical trials to determine whether interventions for cardiovascular disease can prevent or slow the progress of Alzheimer’s disease. On-going trials cover a range of interventions such as statin drugs,...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

...including smoking, diabetes, hypertension and high cholesterol levels are known to play a pivotal role in the pathogenesis of the disease that also recognises a genetic influence. However, it is well known that acute cardiovascular events may happen without the presence of the mentioned common risk factors. Rece...

Hawaiian treasure, macadamia nuts good for the heart

...rican diet. The participants had slightly elevated cholesterol levels, normal blood pressure and were not taking ...reduce total cholesterol, low-density lipoprotein cholesterol and triglyceride levels compared with the standard American diet. "We observed a reduction in LD...

Pistachios lower cholesterol, provide antioxidants

A handful of pistachios may lower cholesterol and provide the antioxidants usually found in leaf...rdiovascular disease by significantly reducing LDL cholesterol levels and the higher dose significantly reduced lipoprotein ratios," says Sarah K. Gebauer, graduat...

Statin treatment improves spatial memory in mouse models of Alzheimer's

..., one of the statin drugs widely used for lowering cholesterol in humans, significantly improved spatial memory -...ionship between memory deficits and high levels of cholesterol in the brain, suggesting that statin’s effects on memory might be due to a reduction in cholesterol ...

A cherry on top: Tart cherries may alter heart/diabetes factors

.... All of the rats had a predisposition toward high cholesterol and pre-diabetes, but not obesity. All the mea...ptibility to salt-linked high blood pressure, high cholesterol and impaired glucose tolerance. For 90 days beginning in their sixth week of life, the rats were...

Chemical maps hint at drug's effects on schizophrenia

... every day to look at metabolites such glucose and cholesterol and determine whether someone is at risk of diabet...gate whether lipids, small fatty molecules such as cholesterol and triglycerides, also may play a role in the disease and in response to therapy. The researcher...

Cold sore virus might play role in Alzheimer's disease

... The gene, which normally plays a role in ferrying cholesterol around the body, is associated with both the cellular tangles and amyloid plaques that are found in the brains of patients with the disease. Researchers have found several ways in which the gene might make a person vulnerable to getting a disease lik...

Link found between immune system and high plasma lipid levels

...ep mice, and possibly humans, from developing high cholesterol and triglyceride levels, a key risk factor for cor...hotoxin (LT) on T cells significantly impacted the cholesterol and triglyceride levels. When T cells expressing LIGHT were introduced into the mice, lipid level...

Dual gene therapy suppresses lung cancer in preclinical test

...FUS1 protein. This is wrapped tightly in a form of cholesterol to protect it from the body's defense mechanisms. "You can't deliver naked DNA for cancer therapy," Ji says. The nanoparticles accumulate mainly in the lungs, particularly in the tumors, Ji says. The positively charged nanoparticles are delivered ...

Growth hormone is not the anti-aging bullet for healthy adults

...clinically relevant outcomes such as bone density, cholesterol levels, stamina, and longevity in this population. "And it's associated with high rates of adverse events. "So, on the basis of available evidence, we cannot recommend growth hormone use for anti-aging in the healthy elderly." Human growth ...

Einstein's tea leaves inspire new blood separation technique

... in many common medical tests, including those for cholesterol levels, drugs in athletes, blood types in donors and glucose levels in diabetics. Current testing requires samples to be taken in a doctor's office and sent off to a laboratory and analyzed with a large centrifuge, a process that can take several day...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...US1 protein. This is wrapped tightly in a form of cholesterol to protect it from the body's defense mechanisms. The nanoparticles accumulate mainly in the lungs, particularly in the tumors, where the genes repeatedly express FUS1 tumor-suppressing proteins. Lung cancer is the leading cause of cancer deat...

Primitive yeast yields secrets of human cholesterol and drug metabolism

...ng-sought protein whose human counterpart controls cholesterol production and potentially drug metabolism. The c...clinically important class of enzymes required for cholesterol synthesis and drug metabolism,?says Peter Espenshade, Ph.D., assistant professor of cell biology at ...

Tiny clue reveals new path toward heart disease

...tors such as smoking, high blood pressure and high cholesterol are known to contribute to coronary artery disease, little is known about genes that render an individual susceptible to developing the disease, said study co-investigator Elizabeth R. Hauser, Ph.D., an associate professor of medicine at the Duke Cen...

Scientists unravel clue in cortisol production

...of the journal Molecular Endocrinology. Turning cholesterol into the stress hormone cortisol involves many rea... along with a battery of other enzymes, transforms cholesterol into cortisol. But what isn't understood is how this protein binding creates CYP 17, or which protei...

Organic is healthier: Kiwis prove that green is good

...in grapefruit and oranges have been shown to lower cholesterol levels in the blood. Two flavanones, hesperidin an...lit into groups with some receiving high levels of cholesterol in their diet. Shela Gorinstein of The Hebrew University in Jerusalem found that after 30 days chole...

Anti-fungal drug stops blood vessel growth

... there is likely some important connection between cholesterol and angiogenesis.? While the researchers still must tease out exactly how itraconazole works to stop vessel growth, and test it in animals with cancer, they have high hopes for its use. “Itraconazole can be taken orally for fungal infection, and t...

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