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Tag: "chemotherapy" at biology news

Second opinion yields treatment changes for half of patients

...onsider new surgery techniques, such as delivering chemotherapy before surgery to make breast conservation possible or sentinel lymph node biopsy, a new technique to determine whether cancer has spread beyond the breast. Thirty-two percent of patients had their surgery recommendations changed based on a multidisc...

St. Jude finds clues to hearing loss from chemotherapy

...ho suffer hearing loss due to the toxic effects of chemotherapy might one day be able to get their hearing back th...hat occurs in children whose hearing is damaged by chemotherapy is loss of hair cells in the inner part of the ear. These cells sprout extremely fine hairs that mov...

Other patients bear the real cost of Herceptin

...and estimated how they could save £1.9m by cutting chemotherapy and palliative care treatments. The sum of £1.9m would enable us to treat 75 patients with Herceptin, but at four times the cost of the adjuvant treatments, they say. These treatments have been proved to be clinically effective and their estimated...

Chemotherapy temporarily affects the structures of the human brain

Researchers have linked chemotherapy with short-term structural changes in cognitive ar...tly smaller in breast cancer patients who received chemotherapy than those who did not. Within four years after treatment, however, there were no differences in the...

Buildup of damaged DNA in cells drives aging

...to a drug that causes DNA damage, such as a cancer chemotherapy agent, the growth hormone axis was similarly suppressed. In other words, DNA damage somehow triggered hormonal changes that halted growth, while also boosting maintenance and repair. Because growth hormone levels go down as we get older, contribut...

Gene chip technology shows potential for identifying life-threatening blood infection

...cancer and predict a patient's response to various chemotherapy drugs, but this is the first time researchers have attempted to use gene chips to distinguish sepsis from non-infectious inflammation. Early symptoms of sepsis and non-infectious systemic inflammation are subtle and similar - fever and an elevated...

Researchers examine why food tastes bad to chemotherapy recipients

...nts currently receiving certain drug therapies and chemotherapy find foods and beverages to have a foul metallic flavor, according to a medical study. In general, more than 40 percent of hospitalized patients suffer from malnutrition due to taste and smell dysfunction. "Unfortunately, these problems that impact...

Two central mysteries in genome inheritance solved at UCSD

...ugs that bind to microtubule polymers ?is a common chemotherapy strategy used to target and curtail rapidly dividi...rgets in cancer cells. "Right now, drugs used in chemotherapy affect microtubules in all the body's cells, resulting in adverse side effects, like nerve pain and ...

Does natural selection drive the evolution of cancer?

...erapeutic resistance," Maley adds. "When you apply chemotherapy to a population of tumor cells, you're quite likely to have a resistant mutant somewhere in that population of billions or even trillions of cells. This is the central problem in oncology. The reason we haven't been able to cure cancer is that we're ...

Abnormal overexpression of p53 is a predictive molecular biomarker

...dicted poor outcome from traditional radiation and chemotherapy treatment for head and neck cancers now has been f...o achieved 100 percent response when combined with chemotherapy to treat locally advanced breast cancer, and a 69 percent response when used with radiation to treat...

Vaccine for brain tumors shows promising results

...ociated with traditional cancer treatments such as chemotherapy and radiation therapy. Vitespen has been granted fast track and orphan drug designations from the Food and Drug Administration in both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). The UCSF clinical trial is a phase1...

Hope for a more effective and less toxic cancer drug

...y damage many normal tissues. Hence, even when the chemotherapy works, the side effects for the patient can be very serious. ABT-737 is a drug with a different strategy for attacking cancer. Rather than attempting to poison the rogue cells, the new drug attempts to reactivate the healthy and normal cell death...

Report calls for improved monoclonal antibodies against solid tumors

...e. That damage causes the toxicity associated with chemotherapy and radiation therapy. In the nearly 20 years since scientists were able to create monoclonal antibodies that could be safely used in humans, eight monoclonal antibodies have been approved for use in clinical treatments to trigger immune responses to...

U-M researchers use nanoparticles to target brain cancer

...rough the bloodstream into the brain. In order for chemotherapy to treat a tumor, it must penetrate this barrier. Researchers tested the nanoparticles in cell cultures and animal models. The studies showed the nanoparticles traveled to the tumor, resulting in less Photofrin exposure throughout the body and en...

Distinguishing friend from foe in the battle against cancer

...ke rapamycin less "friendly." "A major problem of chemotherapy is that sooner or later cancer cells develop resistance, which requires higher and higher doses of chemotherapeutics," observes Verma, who is also an American Cancer Society professor in Salk's Laboratory of Genetics. "Rapamycin-mediated killing of c...

Key to lung cancer chemo resistance revealed

...ed how taking the brakes off a "detox" gene causes chemotherapy resistance in a common form of lung cancer. Prod...pression of these same genes to block assault from chemotherapy drugs. "What we're seeing is that lung cancer cells recruit and distort NRF2 and KEAP1 expression...

'Erectile dysfunction' drugs heighten natural anti-cancer activity

...tioned, "but could be used in addition to standard chemotherapy or immunotherapy treatments." The investigators are planning human studies to begin in the next year. ...

Researchers identify new weapon to fight deadly bacterial sepsis

...d bone marrow transplants, and receiving high-dose chemotherapy for cancer. Young children and elderly people are also at a higher risk for the condition because of their weaker immune systems. Now, Assistant Professor Kota V. Ramana and Professor Satish Srivastava of the University of Texas Medical Branch at ...

Gene signature assesses breast cancer outcomes

... better identify who can safely be spared adjuvant chemotherapy in 6000 women with node-negative early-stage breast cancer. If validated, the tool could safely spare 1 in 6 women the burden of adjuvant chemotherapy. ...

Antibiotic treats lymphoma of the eye

...ents have failed, and it is a valid alternative to chemotherapy and radiation without causing the same toxic side-effects. Patients treated with doxycycline had a 66% rate of disease-free survival. "Our prospective trial revealed that doxycycline is a fast, safe, and active treatment for OAL, both at initial di...

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