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Tag: "chemotherapy" at biology news

Enzyme crystal structure reveals 'unexpected' genome repair functions

...s fails. "Because chemotherapeutic agents like the chemotherapy drug cisplatin and radiation therapy work by essentially damaging DNA, any new understanding of the DNA repair mechanism could mean potential improvements in the treatment of cancer," Tainer says. Prior to this study, there were no specific models f...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...st important in terms of treatment. Cisplatin is a chemotherapy drug that is given for the treatment of metastatic testicular or ovarian cancers, and some advanced bladder cancer, and is a very effective drug in combination with other therapies. However, according to Farrell, these current agents have limited a...

Weighting cancer drugs to make them hit tumors harder

...ptimal drug concentration." Chilkoti said current chemotherapy drugs are so small � molecular weight of 300 to ...molecular weight, the study showed. Chilkoti said chemotherapy by itself is small enough to travel throughout the body via the bloodstream, causing toxicity to vit...

New device could cut chemotherapy deaths

A new method of delivering chemotherapy to cancer patients without incurring side effects ...involves using tiny fibres and beads soaked in the chemotherapy drug which are then implanted into the cancerous area in the patient's body. These fibres are bio-d...

Researchers find molecular 'brake' to cell death

...maximize the decrease of nucleotide levels." Some chemotherapy drugs, like paclitaxel, cisplatin and etoposide, a...can be used to help in the design of more targeted chemotherapy drugs," Tang says. "This will change the way that scientists now think about the role of nucleotides...

Radioactive scorpion venom for fighting cancer

...ompound in an outpatientprocedure, without needing chemotherapy or traditional radiotherapy. The first, early human trials of the venom therapy showed promising signs for treating the tumor and prolonging survival rates for patients. At the Health Physics Society meeting this week in Providence, Rhode Isla...

New genetic test for breast cancer

...apy alone and which patients will truly benefit if chemotherapy is added to the treatment," said Joseph Sparano, M... treatment, we can spare women the side effects of chemotherapy where it is unnecessary." Dr. Sparano is the lead investigator for the clinical trial, called TAILO...

Mass. General study finds potential ovarian cancer stem cells

...-like cancer cells may be resistant to traditional chemotherapy and could be responsible for the ultimately fatal ... of these specialized cells escaped destruction by chemotherapy or radiation, the tumor would be able to recur quickly, often in a form resistant to chemotherapy. ...

U of M researchers discover genetic key to treating deadly fungal infections

...ld clues about how some tumors become resistant to chemotherapy and how researchers can develop companion drugs that inhibit the development of that resistance. About 25,000 Americans develop these fungal infections each year. And in spite of treatment with antifungal drugs, 10,000 die. The number of hospital...

Buckyballs boost antibody's chemotherapy payload

... of using antibodies like ZME-018 to better target chemotherapy drugs like Taxol, and M. D. Anderson's Michael G. Rosenblum, Ph.D., professor in the Department of Experimental Therapeutics and Chief of the Immunopharmacology and Targeted Therapy Laboratory, has conducted some of the pioneering work in this field....

Breast stem cells have features similar to 'basal' tumors

...erceptin are ineffective against basal tumours and chemotherapy is the only option. Dr Lindeman, who is also an oncologist at the Royal Melbourne Hospital, said that their team's findings will now be extended using excised human breast tissue andtumours. "We are fortunate that the Royal Melbourne Hospital campu...

Injection may prevent infertility in men receiving cancer chemotherapy

...m the effects of paclitaxel (Taxol), a widely used chemotherapy drug. "The effects of chemotherapy treatment on fertility are an important issue for long-term survivors of cancer who may not have sta...

Fatty spheres loaded with siRNA shrink ovarian cancer tumors in preclinical trial

...mpty. Some mice received siRNA liposomes plus the chemotherapy docetaxel. Mice receiving the FAK-silencing lipo...ancer cell lines resistant to docetaxel and to the chemotherapy drug cisplatin. The FAK-silencing liposome and the liposome with chemotherapy also reduced the in...

First-ever genomic test predicts which lung cancer patients need chemotherapy to live

...ch patients with early-stage lung cancer will need chemotherapy to live and which patients can avoid the toxic reg... save thousands of lives each year by recommending chemotherapy for patients who are currently advised against it, said the test's developers at Duke's Institute fo...

One therapeutic dose of radiation causes 30 percent spongy bone loss in mice

...complicating factors of the illness itself and the chemotherapy which often accompanies it. "You can't study this in people, so having a well-defined animal model is important," Bateman said. Study focuses on four types of radiation In the current study, the mice received a single 2 Gray (Gy) dose, which is...

Research links protein to breast-cancer migration

...r inhibiting their action may be one way of making chemotherapy treatments more effective." Pamela Goldberg, Chief Executive of Breast Cancer Campaign, added: "The spread of breast-cancer cells to other areas of the body is the single most important factor in breast-cancer mortality. "When breast-cancer cells b...

Major cancer study aims to identify protein markers for early-stage disease

...ions with current therapies -- surgery, radiation, chemotherapy and targeted drug therapy. The technique could also be used to monitor a cancer's response to treatment and to detect the recurrence of cancer after treatment. "This is an extraordinarily exciting endeavor," says Fisher. "We truly believe in this ...

Stem cell expansion

... or has been destroyed (often through radiation or chemotherapy of cancer). HSCs are very rare, and it is often hard to obtain enough of them for a successful transplant. To overcome this limitation, Hans-Peter Kiem and colleagues have developed a way to expand HSCs in the laboratory prior to transplantation. As...

Bacterial protein shows promise in treating intestinal parasites

...lity to control parasitic nematode infections with chemotherapy on a global scale is dependent on the availability of medicines that are safe, effective, and inexpensive to manufacture," said Michael Cappello, one of two principal authors of the study and a professor of pediatrics and epidemiology & public he...

MIT nanoparticles may help detect, treat tumors

...at could kill cancer cells, replacing radiation or chemotherapy treatments that cause negative side effects such as hair loss or nausea. The researchers hold a provisional patent on their work. ...

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