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Tag: "checkpoint" at biology news

New binding target for oncogenic viral protein

...arge T antigen. This protein corrupts the cellular checkpoint mechanisms that guard cell division and the transcription, replication and repair of DNA. T antigen also inactivates some of the most important proteins that protect cells against malignant transformation, including tumor suppressor proteins p53 and ...

Novel connection found between biological clock and cancer

...t result of action by an enzyme, called in mammals checkpoint kinase-2 (CHK2), whose normal role is exclusively ... homolog, the Neurospora version, of the mammalian checkpoint kinase. Moreover, the clock regulates expression of the period-4 gene. This closes a loop connectin...

MIT sheds light on how tumor cells form

... MIT researchers have discovered is a reason these checkpoint proteins may be unable to sense the defective cell...called microtubules. If they attach correctly, the checkpoint proteins give them the go-ahead to divide. If they don't, the checkpoint proteins are supposed to st...

Worm links cancer risk to ageing

...y that is. Professor Lithgow said: "If we look at checkpoint proteins as a gear, we have known for a long time ...r Lithgow now works, involved genetically removing checkpoint proteins in the microscopic worm C. elegans. By doing so, the researchers caused a 15-30% increase i...

Cancer stem cells linked to radiation resistance

...a specific cellular process called the "DNA damage checkpoint response" appears to enable cancer stem cells to s...oth study models, the team examined the DNA damage checkpoint response both before and after use of ionizing radiation treatments by testing for activation of the...

ATR checkpoint-activating DNA structure

... precisely define and manipulate the nature of the checkpoint activating structure in an experimental system will enable us to control, quantitative and probe checkpoint signaling responses in unprecedented ways." Using Xenopus egg extracts as a cell-free system, the...

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