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Tag: "channel" at biology news

Nicotine rush hinges on sugar in neurons

...rge and important group of molecules, known as ion channel proteins, that allow signals to pass between neuro...t when a chemical such as nicotine binds to an ion channel protein on the cell surface, the protein starts a “conformational wave” that propagates a signal thr...

Scripps research team sheds light on long-sought cold sensation gene

...their paw and lick them. TRPM8 codes for an ion channel found at the tips of sensory neurons, which innervate the skin. When opened, ions flowing through TRPM8 lead to the activation of the sensory neuron, which in turn sends a signal to the brain. The Patapoutian team’s results support the idea that acti...

Cornell lab confirms deadly fish virus spreading to new species

...sport fish), northern pike, walleye, yellow perch, channel catfish, brown bullhead, white perch, white bass, ...stating impact on aquaculture and particularly the channel catfish trade, which constitutes about 80 percent of aquaculture business in the United States, said...

UTSA researchers examine effects of global warming on Antarctic

...through the ice and create a 25-mile long shipping channel that would allow for the delivery of annual supplies to NSF's McMurdo Research Station. On route to Antarctica, the ship passed through 1,700 miles of extensive sea ice cover that surrounds the continent annually. "We now know what the sea ice r...

Protein overexpression at heart of heart failure

...eta 2-subunit) that is responsible for the altered channel behavior in human heart failure. Similar changes o...sion transgenic mouse which was crossbred with the channel pore overexpressing mouse when still nonfailing (“Adaptive phase?. In the nonfailing double transgen...

What's in the water? Estrogenic activity documented in fish caught in Pittsburgh's rivers

..." said Dr. Volz. The study examined white bass and channel catfish caught in the Allegheny, Monongahela and Ohio Rivers. These fish are among those commonly caught as a food source by local anglers. The experiments to determine if estrogenic substances were present in the fish were performed in the labor...

Brain networks strengthened by closing ion channels

...c mutation in patients to the regulation by an ion channel of PFC neuronal networks," said Arnsten. ...

The connector rotation hypothesis? Phage do not pack their DNA by rotation

...hat the DNA passes into the capsid shell through a channel formed by a structure called the connector. Scientists have speculated that rotation of the connector complex might feed the DNA into the capsid as it turns. In a new study published online this week in the open access journal PLoS Biology, resear...

Scripps Research study reveals new activation mechanism for pain sensing channel

...w exactly how cysteine binding translates into ion channel activation." But this activation mechanism com...ation of reactive cysteines within TRPA1 can cause channel activation," Macpherson said. "Our research efforts are now aimed at further understanding how bindi...

Anti-dandruff compound may help fight epilepsy

... chemical that proved quite effective in improving channel recovery was zinc pyrithione (ZnPy), the active in... that allows it to fit into the gate region of the channel protein and allow more potassium flow. “If you think of these channels as doors on the cell’s surfac...

New approach could lower antibiotic requirements by 50 times

...in or tetracycline. It is the phages' ability to channel through bacterial cell membranes that boosts antibiotic effectiveness. 'Pseudomonas bacteria for example are particularly multi-resistant to antibiotics because they have efflux pump mechanisms that enable them to throw out antibiotics. A pore in the...

On automatic pilot

... inside and outside of the cerebellum: how does it channel information and process this into a signal to the muscles? Subsequently they investigated which parts of the cerebellum are involved in regulating the activity of a single muscle. Furthermore, they examined the consequences of inactivation of one or ...

Researchers seek to design first treatment for neuroAIDS

...ls. These include antioxidant medications, calcium channel antagonists, NMDA antagonists like the Alzheimer's drug Memantine, platelet activating factor (PAF) inhibitors, and in the case of the new grant, drugs that inhibit glycogen synthase kinase 3 beta (GSK-3b) and mixed lineage kinase (MLK). "The number...

Tarantula venom and chili peppers target same pain sensor

...at target them. The capsaicin receptor acts as a channel on the nerve surface. When certain compounds bind to it, the receptor channel opens, allowing a stream of charged sodium and calcium molecules to rush into the nerve cell. This g...

The power of one: A simpler, cheaper method for cell fusion

... my device, the narrow section in the microfluidic channel is so small that only two to three cells fit into it," Lu said. Lu said he believes that his device may be developed to have a higher throughput than current methods. Although Lu's technology currently fuses single pairs at once, it may be expande...

Origin of inherited pain disorder pinpointed

...scovery that they said emphasizes the role of such channel disorders in inflammatory pain. Such findings of a... that they all disrupted the ability of the sodium channel to rapidly snap shut, prolonging activation of the peripheral nerves in which the channels functione...

UCLA researchers unravel a mystery about DNA

...that the scrunched DNA is expelled from the enzyme channel at predictable sites that are available for interaction with transcription regulatory proteins. Beyond resolving the mechanism for initiation, the significance of this work is in pointing out an important regulation "checkpoint." Scrunched DNA is lik...

MIT designs portable 'lab on a chip'

...iature laboratories of fluid being pumped from one channel to another, with reactions going on here and there...d blood cell is about 8 microns in diameter.) Each channel has its own pumps, which direct the fluids to certain areas of the chip so they can be tested for th...

New biochip helps study living cells, may speed drug development

...lp develop drugs for human disorders involving ion channel malfunction, such as epilepsy and chronic pain. About 15 percent of the drugs currently in development affect the activities of ion channels, he said, and their development is limited by the slower pace of current technology. The biochip would allow ...

Researchers add to understanding of how brain cells communicate

...rs at synapses. The flow of calcium ions through a channel in NMDA receptors plays a central role. Neurons...ngly excited, magnesium ions are expelled from the channel of NR1/2A receptors, one NMDA receptor subtype. Calcium ions then can flow through the open channel ...

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