Topical treatment shown to inhibit HIV and herpes simplex virus infection
...prevent HIV and HSV infection of susceptible human cells in culture. Levels of inflammatory cytokines were also measured as markers of acute inflammation. Analyses showed that CVL obtained after the application of PRO 2000 gel reduced both HIV and HSV infectivity by at least 1000-fold compared to CVL obta...Priming embryonic stem cells to fulfill their promise
...have invented a process to help turn embryonicstem cells into the types of specialized cells being sought as possibletreatments for dozens of human diseases and health conditions. SangeetaBhati...Growth in the sea comes down to a struggle for iron
...ic. Even with additional iron, large phytoplankton cells in the east do not appear to grow as readily. Since prevailing winds tend to blow iron rich dust off the Asian continent into the Pacific, it may be that phytoplankton closer to the source of that dust may be primed to respond differently. Wells and...New, automated tool successfully classifies and relates proteins in unprecedented way
...roteins.These proteins were produced inside living cells using a technologycalled CD tagging, which was developed by Jonathan Jarvik and PeterBerget, both associate professors of biological sciences at CarnegieMellon. The computational analyses were carried out together with XiangChen, a graduate student i...New binding target for oncogenic viral protein
...s some of the most important proteins that protect cells against malignant transformation, including tumor suppressor proteins p53 and pRb. In the Journal of Biological Chemistry paper, Dr. Welcker and Dr. Bruce Clurman report that T antigen also binds to another tumor suppressor, Fbw7. This protein is pa...Lack of enzyme turns fat cells into fat burners
...ylase 2or ACC2, appears to turn the adipose or fat cells of mice into fatburners, explaining in part why th...e NationalAcademy of Sciences. "Westudied the fat cells in these mice bred to lack ACC2," said Dr. SalihWakil, chair of the BCM department of biochemistry a...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
...from the mother to the baby, the baby's pancreatic cells will be programmed abnormally," said principal inv...pancreas doesn't make enough insulin or the body's cells develop a resistance to its effect. Without insulin, glucose cannot get into cells to provide energy...Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
...edicine are conducting a clinical trial using stem cells generatedwithin the bone marrow to grow new blood ..., to prod the bone marrow torelease a type of stem cells called endothelial progenitor cells, whichare used by the body to form new blood vessels or to repai...Fox Chase Cancer Center scientists identify immune-system mutation
...d immunity) and also for helping other white blood cells (B cells, derived from bone marrow) generate antib...gainst foreign agents that enter the body. Other T cells are known as killer cells because they attack foreign invaders more directly. "The maturation of T ...Controversial drug shown to act on brain protein to cut alcohol use
...culture, and evidence of toxicity to certain nerve cells in rodentstudies have discouraged careful studies of its clinical potentialagainst drug and alcohol addiction. The FDA has not approved use ofIbogaine in the U.S.Scientists at UCSF's Ernest Gallo Clinic and Research Center have nowshown definitively ...Neuronal 'traffic jam' marks early Alzheimer's disease
...r transport system and thus the viability of brain cells otherwise lost in Alzheimer's. The findings also c...lzheimer's pathology by using human embryonic stem cells to differentiate into neurons in culture. Their goal is to alter those neurons genetically by introd...Current human embryonic stem cell lines contaminated UCSD/Salk team finds
Currently available lines of human embryonicstem cells have been contaminated with a non-human molecule t...lycolylneuraminic acid (Neu5Gc), even though human cells aregenetically unable to make it. In a related paper published November29, 2004 by the Journal of Bi...Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
Brain cells in a mouse model of Alzheimer'sdisease have surpri...ther scientists hadregarded plaque damage to nerve cells as a fait accompli--somethingthat the plaques only needed to inflict on nerve cells once. Accordingt...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
...ba lacked many of the visible traits of eukaryotic cells (such as endoplasmic reticulum, golgi apparatus an...ethods to kill bacteria as it uses to damage human cells and cause disease, the level of certain bacteria in the colon can be an important determinant of the...Key molecule in plant photo-protection identified
Brain cells in a mouse model of Alzheimer'sdisease have surpri...ther scientists hadregarded plaque damage to nerve cells as a fait accompli--somethingthat the plaques only needed to inflict on nerve cells once. Accordingt...Newly-discovered class of genes determines ?and restricts ?stem cell fate
Research on adult stem cells found in the skin hints at a new class of genes, a...the skin and hair ?is also expressed in adult stem cells in the skin. "Our findings told us that a recapitulation of an embryonic program is occurring in re...Plants, animals share molecular growth mechanisms
...hole plant and also the shape and size of types of cells in the plant." Results of the study are published...or actin filament formation, we can engineer plant cells to grow in different ways or alter how cells respond to external stimuli so they can defend themselv...Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
...nsidered a uniform disease of immature white blood cells that didn't die, with the slow rise in leukemia ce...d cells. Scientists have since discovered that CLL cells do indeed turn over, with the accumulation over time a result of the difference in the birth and dea...Plants respond similarly to signals from friends, enemies
...w for real-time, three-dimensional study in living cells over time, the NC State researchers discovered tha...mation of either nodules housing bacteria or giant cells from which the nematodes feed. The scientists also discovered that, like rhizobia and contrary to p......ked HCV construct was then placed into human liver cells in a cell culture medium. The NIDDK scientists fo...of HCV proteins and HCV RNA within the human liver cells in the culture. Electron microscopy showed evidence of high levels of viral particles resembling ful...