cell 2 10

Tag: "cell" at biology news

MicroRNAs as tumor suppressors

...NA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3?end of the HMGA2 transcript, and prevent let-7 binding, result in aberrantly high levels of HMGA2 expression and tumorigenesis. This paper establishes that HMGA2 is a target of let-7, and that t...

Putting an old drug to a new use

...erload disorders." Combining electrophysiology, cell biology and molecular investigations, Weiss and hi...olecule called DMT-1. DMT-1 transports iron across cell membranes. This transport is increased ten to 100-fold by nifedipine, but how exactly the compound ...

Researcher to study astronaut bone loss for space biology agency

...Earth's gravity, an event known as reloading, bone cell production can take months to return to normal. Du...el of skeletal loading and unloading in human bone cell culture. In the second part, skeletally unloaded rats will be treated with IGF-1 and reloaded on a r...

Darwin's famous finches and Venter's marine microbes

... enzymes, which control every aspect of eukaryotic cell biology and are important cancer drug targets. They control the activity of proteins and small molecules by attaching tiny phosphate groups to them. By contrast, much less has been known about their bacterial counterparts. Again and again, the res...

Scientists discover stage at which an embryonic cell is fated to become a stem cell

... the inside of the embryo. These become the inner cell mass of stem cells. Previously, it was believed t...tem cells of the embryo." The study also found cell fate and transcription activity is determined by the level of a methylated form of histone H3, one o...

New cell type identified in cancer development

Scientists have discovered a new type of cell that appears to play a role in the development of cancer ?a highly volatile, precancerous stem cell that can either remain benign or become malignant, depending upon environmental cues. The finding m...

Destructive enzyme shows a benevolent side

...the mRNA ?helps form temporary shelters within the cell called stress granules. There, the mRNA can be pro...henever the stress ends, perhaps insuring that the cell survives. Stress granules are short-lived aggregates of mRNA and proteins, and they accumulate wh...

Scientists sequence genome of parasite responsible for common sexually transmitted infection

... the urogenital tract, which resulted in increased cell size and, subsequently, a considerably expanded genome. The researchers also discovered more than 150 instances where bacterial genes may have transferred into the parasite's genome, suggesting that bacteria may have influenced the development of...

Elucidation of the genome for diabetics with DNA chips

...ntrolling the Wnt signalling pathway essential for cell survival. Studies in animals have shown that the absence of these genes impairs pancreatic function. EXT2 encodes an enzyme involved in the foetal development of several organs, including the pancreas. This enzyme also regulates Wnt signalling. ...

Scientists find potential 'off-switch' for HIV virus

...ticle invades a T cell, most often it converts the cell into a factory for making other viral particles, killing the cell in the process. Without these T cells, the body loses its ability to repel other infectious bacteria...

New molecular pathway could reveal how cells stick together

...in whole flies," Page-McCaw said. "When you take a cell out of the organism it behaves a little bit differently. So while you can work out cell mechanisms in cell culture, then you want to go back and demonstrate their relevance to the animal."...

Massey researchers induce cell death in leukemia

... Parallel studies conducted on two established CLL cell lines provided additional preclinical evidence tha...teracts synergistically with both agents to induce cell death in human CLL cells. Romidepsin and belinostat are histone deacetylase (HDAC) inhibitors. "...

Instruction manual for creating a molecular nose

...als from molecules in the air, for example, to the cell interior. They are thus ideal biosensors, but un...tly from the genetic information introduced to the cell extract. Previous attempts to create biosensors from membrane proteins failed due to an idiosyncr...

UCSF brain tumor vaccine trial shows promising results

...r both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). Reviewing the presentation at AANS, Henry Brem, MD, director of neurosurgery at the Johns Hopkins Medical Institutions, noted, “This is an encouraging study of a therapeutic cancer vaccine that targets multiple tumor an...

What's in the water? Estrogenic activity documented in fish caught in Pittsburgh's rivers

...unicipal wastes resulted in the greatest amount of cell growth. "We decided to look at pisciverous fi...that two bass extracts produced strong-to-moderate cell growth, as did five catfish extracts. "We know that there are hundreds, even thousands, of chemi...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...ithelial neoplasia lesions ?abnormal, precancerous cell growths found in the cervix. They also found ...er Institute. The researchers gave a dendritic cell vaccine to 12 pancreatic cancer patients. Four of the subjects have shown no signs of recurrence in ...

Researchers develop technique for bacteria crowd control

...f tiny electric current in a very thin film sample cell containing a colony of bacteria. The current produces electrolysis that changes the local pH level in the vicinity of the electrodes. The bacteria, uncomfortable with the changes in pH, swim away from the electrodes and ultimately congregate in the ...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

...ocking the proteins the virus uses to latch onto a cell and infect it. In 1998, Dr. Kwong and colleagues published the first X-ray snapshot of the core of HIV gp120 as it attaches to a cellular receptor known as CD4. That image gave researchers a glimpse of some sites on the virus that could be targ...

Researchers urge monitoring of bone health during chemotherapy

...cher, M.D., assistant professor of medicine and of cell biology and physiology. "But there are things that...F has recently increased because by speeding blood cell regrowth it allows patients to undergo more intensive chemotherapy regimens in which anticancer agen...

Protein sensor for fatty acid buildup in mitochondria

...is breakdown of fatty acids, in turn, provides the cell energy while reducing the chance that excess fatty...essed by CoA—the molecule this enzyme triggers the cell to make. CoA normally binds tightly to PanK2, shutting it down. When a buildup of fatty acids occurs...

1 2 3 4 5 6 7 8 9 10