Insulin pulses keep the liver lean
...make or respond to insulin in people with diabetes causes blood sugar levels to rise. The current study uncovered a new mechanism whereby acute insulin pulses limit fat synthesis in the liver. This protective mechanism fails in obese mice and mice with persistently high levels of insulin, the researchers a...... contribute towards the clarification of the viral causes of lower respiratory tract infections generally; causes that have not always been apparent despite the frequency of such infections amongst children. ...Gene therapy advance treats hemophilia in mouse models
...us called feline immunodeficiency virus (FIV). FIV causes leukemia in cats but no disease in humans. The h...ses the therapeutic gene so that its promoter that causes gene expression worked only when it was in a liver cell. "Even if this FIV modified virus goes to o...Researchers devise new technique for creating human stem cells
...omatic cells with embryonic stem cells. The fusion causes the adult cells to undergo genetic reprogramming, ... a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. Eggan, Melton and their colleagues decid...Elevated temperature enhances success of viral cancer therapy
...a specially designed virus similar to the one that causes the common cold has shown promise in clinical trials. Now, new research suggests that fever might be a useful weapon in the fight as well. The study, published in the July issue of Cancer Cell, demonstrates that tumor cells are even more sensitive to...Mass production of human papillomavirus could lead to gains against cervical cancer
... of exploiting the vulnerabilities of a virus that causes cervical cancer, thanks to a newly developed techn...rs. A more common, less virulent form of the virus causes genital warts. Using the new technique scientists can quickly produce a thousand times more infecti...Malfunctioning bone marrow cells sabotage nerve cells in diabetes
...ications. Neuropathy is a common complication that causes pain and ultimately loss of sensation in the extremities and can lead to amputation. Previously, Chan and members of his laboratory had found that bone marrow cells were among a group of cells in organs other than the pancreas that unexpectedly prod...Hide and seek: Researchers discover a new way for infectious bacteria to enter cells
...s have learned how Listeria monocytogenes, which causes a major food-borne illness, commandeers cellular transport machinery to invade cells and hide from the body's immune system. They believe that other infectious organisms may use the same mechanism. The Listeria bacterium, found in soil and water,...Gene therapy to lower blood pressure just enough
...ences. "High blood pressure is one of the leading causes of death and disability in adults worldwide," said Dr. Bert O'Malley, chair of the BCM department of molecular and cellular biology. "A therapy that could control blood pressure could have important benefits for individuals and for the health of the ...Gene discovery sheds light on causes of rare disease, cancer
...s have learned how Listeria monocytogenes, which causes a major food-borne illness, commandeers cellular transport machinery to invade cells and hide from the body's immune system. They believe that other infectious organisms may use the same mechanism. The Listeria bacterium, found in soil and water,...Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy
...art failure in mice with the genetic mutation that causes Duchenne muscular dystrophy, according to scientis...dical School. The mutation in the dystrophin gene causes the progressive deterioration of skeletal muscles seen in people with MD. But the mutation affects c...U of MN researchers reverse memory loss in mice
...rther designed the mice so that the transgene that causes these symptoms could be "turned off." Transgenes are genes from one organism that have been incorporated into another organism. The researchers predicted that when the transgene expressing the dementia was turned off, memory loss would stop. The res...AIDS expert says global strategy needed to combat feminization of HIV/AIDS
...ldwide currently infected with HIV, the virus that causes AIDS, and in some developing countries, women represent the vast majority of those living with HIV/AIDS. At the start of the pandemic in the early 1980s, men accounted for almost 90 percent of cases in developed countries. In the United States from ...Researchers create infectious hepatitis C virus in a test tube
...ns undetected for years, or even decades, until it causes advanced liver disease. ...Defect in gene causes 'neuralgic amyotrophy'
...peripheral nervous system. This heritable disease causes prolonged acute attacks of pain in the shoulder or arm, followed by temporary paralysis. Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the University of Antwerp, have uncovered a small piece of the molec...Primate virus jumps species barrier to humans for first time in Asia
...sidents hunt monkeys for food. HIV, the virus that causes AIDS in humans, is believed to have originated as simian immunodeficiency virus (SIV), and jumped the species barrier to humans when African bushmeat hunters came into contact with blood from infected animals. Though bushmeat hunting and consumption...Quantum dots provide a faster, more sensitive method for detecting respiratory viral infections
...her highly susceptible group. Worldwide, the virus causes about one million deaths annually. Current methods of detecting the virus can take from two to six days, postponing effective treatment. The new, high-tech method uses multi-colored, microscopic fluorescent beads, called quantum dots, which bind to ...Researchers predict infinite genomes
...olates of Bacillus anthracis (the bacterium that causes anthrax), for instance, Tettelin and colleagues found that just four genomes were sufficient to characterize its pan-genome. That raises interesting questions about rates of evolution, notes Fraser. "We're intrigued to learn more about the diversity ...Hopkins scientists uncover 'tags' that force proteins to cell surface
... the docking point that allows HIV, the virus that causes AIDS, into cells, the researchers discovered. Because proteins on the cell surface are "lock-on" sites for drugs and other molecules, as well as triggers of immune reactions, the findings, described in the Sept. 11 advance online publications of Nat......, where they form cysticerci. The infection rarely causes symptoms in pigs. Only cysticerci- not eggs- can develop into the adult form, so if you prevent infection in pigs, you can break the life cycle, says team member Charles Gauci. The Australian group has created a vaccine based on two proteins found o...