Probing The Promise And Perils Of Nanoparticles
...s of nanoparticles damage cell membranes—enough to cause cell death in some cases—and how the damage can be...y behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl....Researchers discover molecule that causes secondary stroke
...nnati (UC) College of Medicine have discovered the cause of a deadly type of secondary stroke known as cere...PhD, it must be exposed to powerful oxidizers that cause the production of significant amounts of the BOXes. The correlation between elevated BOXes, bilirubi...Same mutation aided evolution in many fish species, Stanford study finds
...have found that mutations in the same gene in mice cause altered hair patterns. However, in mice similar al...r Fresno. Perhaps mutations in the two other genes cause problems for the fish in addition to reducing the number of armor plates, Kingsley said. Most of th...Researchers trace evolution to relatively simple genetic changes
... viable and healthy,' he said. "Eda gene mutations cause a disease in humans, but not in the fish. So this ...associated with a clinical syndrome. Instead, they cause evolution of a new phenotype in natural populations." The research with the wild fish also shows th...Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
... viable and healthy,' he said. "Eda gene mutations cause a disease in humans, but not in the fish. So this ...associated with a clinical syndrome. Instead, they cause evolution of a new phenotype in natural populations." The research with the wild fish also shows th...Studies reveal methods viruses use to sidestep immune system
... well as through sexual contact and is the leading cause of cirrhosis and liver cancer. UT Southwestern Medical Scientist Training Program (MSTP) student Eileen Foy was an author on all three papers. MSTP student Rhea Sumpter and postdoctoral researcher Dr. Yueh-Ming Loo were authors on two of the papers....Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers
...ing. The result is excess internal oxygen that can cause oxidative damage -- the destruction of biomaterial due to excess oxygen -- to tissues. To protect their bodies, insects like grasshoppers discontinue breathing. "We propose that most insects stop breathing in order to lower their internal oxygen con...New SARS Protein Linked To Important Cell Doorway
...mportant contributor to the SARS virus' ability to cause disease and death. When the SARS virus first jump...s orf7a is important to the SARS virus' ability to cause disease, scientists will already have much of the knowledge they need to develop ways to disable or ...UCLA scientists transform HIV into cancer-seeking missile
... a version of HIV from which the viral pieces that cause AIDS had been removed. This allowed the virus to i...t and bind with P-glycoproteins. "P-glycoproteins cause big problems by making the cell resistant to chemotherapy," said Chen. "They act like soccer goalies...Gene vaccine for Alzheimer's disease shows promising results
...tems of miceto fight against amyloid proteins that cause the devastating plaquesthat are characteristic of Alzheimer's disease.For years scientists have examined the possibility of using aprotein-based vaccine to slow the progression of the disease in itsearly stages. UT Southwestern researchers have creat...Scientists identify molecular events that drive cell senescence
...tems of miceto fight against amyloid proteins that cause the devastating plaquesthat are characteristic of Alzheimer's disease.For years scientists have examined the possibility of using aprotein-based vaccine to slow the progression of the disease in itsearly stages. UT Southwestern researchers have creat...The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
... and bacteria, including the pathogenic types that cause pneumonia, anthrax, and tuberculosis. The nine PSI pilot centers have transformed protein structure determination from a mostly manual process to a highly automated one. Robotic instruments rapidly clone, express, purify, crystallize, and analyze ma...New research indicates a 'troubled' greenhouse is brewing
... agrees with previous research indicating that the cause of the late Paleocene greenhouse spike, which lasted less than half a million years, was a catastrophic release of natural gas from undersea ices and permafrost. "In a remarkable parallel to modern hydrocarbon pollution of the atmosphere, this natur...Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease
... the formation of the brain-clogging deposits that cause such disorders as Alzheimer's and Parkinson's diseases, Duke University chemists have figured out how to capture and "micromanipulate" the single molecular building blocks of the deposits. Their aim is to understand the detailed assembly process for...Newly Discovered Compound Blocks Known Cancer-Causing Protein
...mponent of the cell, but mutations in the gene can cause it to become stuck in an "on" position, promoting uncontrolled cell growth. Mutations in Ras that permanently activate it have been found in half of all colon cancer and 90 percent of pancreatic cancers, among other cancers. Casey and his colleagues...Plants defy Mendel's inheritance laws, may prompt textbook changes
...nts and animals in order to correct mutations that cause diseases and abnormal growth. Though further research is required to learn how this form of inheritance happens and how it can help improve plants or animals through gene therapy, Pruitt said the discovery has opened an important new line of thinkin...Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
...ting the APC gene was found, as in human cells, to cause the accumulation of a protein called beta-catenin in the nuclei of these cells. Kaestner's group had earlier published research on a transcription factor called Foxl1 that is also expressed in the colon, but in a different layer of cells, adjacent t...Bird Brains Show How Trial and Error May Contribute to Learning
...serenading females. Kao wondered whether she could cause changes in bird song by manipulating this region. Learning takes some time, so Kao expected to wait for her results. But stimulating the LMAN had an immediate impact. The tune and rhythm of the basic song did not change, but a tiny burst of electric...TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
...development of B lymphoma. "TEL2 doesn't directly cause cancer," Grosveld said. "Instead, this gene promotes the development of lymphoma by enlarging the B lymphocyte population. This increases the likelihood that at least a few of the cells acquire a mutation eliminating p53 function just by chance. In t...Unexpressed But Indispensable -- The DNA Sequences That Control Development
... likely that mutations in these critical sequences cause human diseases. Studying how such mutations drive development astray may lead to better understanding not only of these diseases, which are likely to be rare, but also of normal human development. ...