Tag: "cartilage" at biology news

Gene therapy converts dead bone graft to new, living tissue

...ically target the genes to the edge of the damaged cartilage during arthroscopic surgery, but we're looking to use the same idea of triggering the cartilage to remake itself." Schwarz's work on bone revitalization and LAGT has just been recognized as one o...

Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems

... kidney disease late in life, but also may lead to cartilage degeneration and impaired memory and learning abil...aintenance of cognitive function and prevention of cartilage degeneration," Sonntag and his colleagues reported in an article in Endocrinology, published on-line...

Gene therapy promising for growing tooth-supporting bone

...P-7 is part of a family of proteins that regulates cartilage and bone formation. Recent studies have shown that BMPs are present in tooth development and periodontal repair. This study mixed BMP-7 genes with an inactivated virus in a gel-like carrier and injected it into wounds. Giannobile said using a virus,...

Nano-bumps could help repair clogged blood vessels

...ave shown in a series of experiments that bone and cartilage cells in petri dishes attach better to materials that possess smaller surface bumps than are found on conventional materials used to make artificial joints. The smaller features also stimulate the growth of more new bone tissue, which is critical for...

Scientists discover that three overlapping signals in embryo help get the backbone right

...nt, this protein factor is critical in laying down cartilage to make joints, and even plays an important role after birth. Recently, he and Stanford University colleagues showed that noggin may be important in preventing the premature fusion of the bones in the skull, and thus may be critical to allowing the b...

Researchers Closer To Helping Hearing-Impaired Using Stem Cells

...ls -- a type of stem cell from which fat, bone and cartilage normally develop. “We were interested in marrow stromal cells because of their potential for use in autologous cell-based therapy,?said Dr. Hashino, referring to cell transplantation in which a patient’s own cells are used in treatment. The cells ca...

Enzyme's newly discovered role may make it target for arthritis treatment

...ccumulation of immune cells can lead to tissue and cartilage damage in joints, causing pain and limiting mobili...-reactivity that they will bind to the mouse's own cartilage and collagen and initiate an inflammation," Pham explains. "This leads to a condition similar to rhe...

Study finds adult stem cells can replicate

...ccumulation of immune cells can lead to tissue and cartilage damage in joints, causing pain and limiting mobili...-reactivity that they will bind to the mouse's own cartilage and collagen and initiate an inflammation," Pham explains. "This leads to a condition similar to rhe...

Arthritis: What Wnt wrong?

...ynovium (or joint lining) and weak localization to cartilage and bone. In addition, strong Wnt-7b expression mo...er inflammatory cytokines were produced in primary cartilage and synovial cells from arthritic versus normal joints. While OA cells did not differ from controls,...

New research could help us deliver genes for new bone formation

...cientists are working on new methods to regenerate cartilage and bone by delivering genes to stem cells within the body to instruct them to turn into bone cells. The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), could lead to a new approach to tissue engineering. With ...

Clinical trial to test stem cell approach for children with brain injury

...nchymal stem cells, which differentiate into bone, cartilage and fat cells, and research indicates can also differentiate into neurons; and hematopoietic stem cells, which form all the cells needed for blood. Preclinical research indicates that the mesenchymal stem cells play the major role in producing new...

Scientists use stem cells to grow cartilage

...essfully converted human embryonic stem cells into cartilage cells, offering encouragement that replacement cartilage could one day be grown for transplantation. Cartilage is the dense connective tissue usually found ...

Cells from amniotic fluid used to tissue-engineer a new trachea

... cells from the amniotic fluid to grow sections of cartilage tube, and then implanting these living grafts into...caused the mesenchymal cells to differentiate into cartilage cells. When the engineered grafts were ready, they were used to reconstruct defective tracheas in se...

From one cell, many possible cures

...sue . . . regenerate injured bone . . . create new cartilage or skin . . . even reverse nerve damage. Human stem cells offer tremendous hope for the development of revolutionary medical treatments for these and a variety of other human health problems. Up until now, however, stem cell research has been slowed...

Stem cells from muscles can repair cartilage

Damage to articular cartilage (cartilage covering the ends of bones where they m...d experimental approaches to repair this articular cartilage have achieved limited results, but currently there is no method to fully restore this type of injure...

UF scientists reveal ancient origin of vertebrate skeleton

...tists found the same essential protein that builds cartilage in this odd animal - it spends the first five year... years. It is essential in the human body, forming cartilage throughout embryonic skeleton and generally serving as a framework for building bone. With GuangJun...

Rice bioengineers pioneer techniques for knee repair

...gh self-assembly technique for growing replacement cartilage offers the first hope of replacing the entire arti... nothing but donor cells, grew dime-sized disks of cartilage with properties approaching those of native tissue. In a follow-up study due for publication soon, g...

UF scientists reveal ancient origin of vertebrate skeleton

...tists found the same essential protein that builds cartilage in this odd animal - it spends the first five year... years. It is essential in the human body, forming cartilage throughout embryonic skeleton and generally serving as a framework for building bone. With GuangJun...

NJIT engineer poised to take stem cell research a step forward

...her stem cell techniques to help patients who have cartilage damage. She and Jaffe will spur cartilage regeneration by combing stem cells with bio-degradable scaffolds that mimic fibers found in human ca...

Bone and cartilage growth to blame for heart valve disease

... reprogram into bone cells in the aortic valve and cartilage cells in the mitral valve, says principal investigator Nalini Rajamannan, MD, newly appointed director of the Center for Heart Valve Disease in the Bluhm Cardiovascular Institute of Northwestern Memorial Hospital and assistant professor of medicine, ...

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