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Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

In a first, Carnegie Mellon University scientists have "programmed" cells to make their own contrast agents, enabling unprecedented high-resolution, deep-tissue imaging of gene expression. The results, appearing in the April issue of Nature Medicine, hold considerable promise for conducting preclinical studies in the emerging field of molecular therapeutics and for monitoring the delivery of ther...

Robot-based system developed at Carnegie Mellon detects life in Chile's Atacama desert

A unique rover-based life detection system developed by Carnegie Mellon University scientists has found signs of life in Chile's Atacama Desert, according to results being presented at the 36th Lunar and Planetary Science Conference March 14-18 in Houston. This marks the first time a rover-based automated technology has been used to identify life in this harsh region, which serves as a test bed f...

Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University

Results reported at American Chemical Society meetingA chemical catalyst developed at Carnegie Mellon University completely destroys dangerous nitrophenols in laboratory tests, according to Arani Chanda, a doctoral student who is presenting his findings on Sunday, Aug. 28, at the 230th meeting of the American Chemical Society (ACS) in Washington, D.C. (Division of Industrial and Engineering Chemi...

Carnegie Mellon University research reveals how cells process large genes

Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form a template for proteins called messenger RNA (mRNA). Mistakes in RNA processing can reduce the expression of a function...

Carnegie Mellon cyLab researchers work to develop new red tide monitoring

Carnegie Mellon CyLab computer scientist Yang Cai is working with NASA's Earth-Sun System Technology Office (ESTO), the Goddard Space Flight Center (GSFC) and the National Oceanic and Atmospheric Administration (NOAA) to develop new software for detecting and tracking toxic algae plaguing North American waters. . "We are developing software that will monitor dangerous algae and various biochemica...

Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace

An international team of scientists for the first time has detected a memory trace in a living animal after it has encountered a single, new stimulus. The research, done with honeybees sensing new odors, allows neuroscientists to peer within the living brain and explore short-term memory as never before, according to scientist Roberto Fernández Galán, a leading author on the report who is current...

Carnegie Mellon scientists create PNA molecule with potential to build nanodevices

No matter how healthy a life one leads, no person has managed to live much longer than a century. Even though the advances of the modern age may have extended the average human life span, it is clear there are genetic limits to longevity. One prominent theory of aging lays the blame on the accumulation of damage done to DNA and proteins by “free radicals,?highly reactive molecules produced by the...

Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

A standard Internet protocol that checks errors made during email transmissions has now inspired a revolutionary method to transform DNA microarray analysis, a common technology used to understand gene activation. The new method, which blends experiment and computation, strengthens DNA microarray analysis, according to its Carnegie Mellon University inventor, who is publishing his findings in the...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

Carnegie Mellon University scientist Chien Ho and his colleagues have developed a promising tool that uses magnetic resonance imaging (MRI) to track immune cells as they infiltrate a transplanted heart in the early stages of organ rejection. This pre-clinical advance, described in an upcoming issue of the Proceedings of the National Academy of Sciences (PNAS), ultimately could provide a non-invas...

Carnegie Mellon scientists show brain uses optimal code for sound

Scientists at Carnegie Mellon University have discovered that our ears use the most efficient way to process the sounds we hear, from babbling brooks to wailing babies. These results represent a significant advance in our understanding of how sound is encoded for transmission to the brain, according to the authors, whose work is published with an accompanying "News and Views" editorial in the Feb...

DNA conclusive yet still controversial, Carnegie Mellon professor says

Although the odds that DNA evidence found at a crime scene will match by chance the DNA of a person who was not there are infinitesimal, controversy continues about DNA identification and its use in criminal investigations, says Carnegie Mellon University Statistics Professor Kathryn Roeder. Roeder will present a historical overview of the use of DNA identification on Tuesday, April 25, during th...

Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds

Most sexually active teenage girls know relatively little about sexually transmitted diseases (STDs) until it is too late, according to a paper by Carnegie Mellon University researchers that will be published in the January edition of the Journal of Adolescent Health. . .. The results came from a survey of 300 adolescent girls in the Pittsburgh area....

Carnegie Mellon researchers discover new cell properties

Carnegie Mellon University researchers Kris Noel Dahl and Mohammad F. Islam have made a new breakthrough for children suffering from an extremely rare disease that accelerates the aging process by about seven times the normal rate. . Dahl, an assistant professor of chemical and biomedical engineering at Carnegie Mellon, said her work with researchers at the National Cancer Institute of the Nation...

Carnegie Mellon researchers discover key deficiencies in brains of people with autism

In a pair of groundbreaking studies, brain scientists at Carnegie Mellon University and the University of Pittsburgh have discovered that the anatomical differences that characterize the brains of people with autism are related to the way those brains process information. . Previous studies have demonstrated a lower degree of synchronization among activated brain areas in people with autism, as...

Carnegie Mellon scientists use 'green' approach to transform plastics manufacturing

Using environmentally safe compounds like sugars and vitamin C, scientists at Carnegie Mellon University have vastly improved a popular technology used to generate a diverse range of industrial plastics for applications ranging from targeted drug delivery systems to resilient paint coatings. . The revolutionary improvement in atom transfer radical polymerization (ATRP) now enables large-scale pro...

Carnegie Mellon University research shows how sensory-deprived brain compensates

Whiskers provide a mouse with essential information to negotiate a burrow or detect movement that could signal a predator's presence. These stiff hairs relay sensory input to the brain, which shapes neuronal activity. In a first, studies of this system by Carnegie Mellon scientists show just how well a mouse brain can compensate when limited to sensing the world through one whisker. Published Apr...

Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

PITTSBURGH -- Carnegie Mellon University scientists have made an important discovery that aids the understanding of why HIV enters immune cells with ease. The researchers found that after HIV docks onto a host cell, it dramatically lowers the energy required for a cell membrane to bend, making it easier for the virus to infect immune cells. The finding, in press in Biophysical Journal, will prov...
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