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Tag: "cargo" at biology news

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

... shown that common bacteria can deliver a valuable cargo of "smart nanoparticles" into a cell to precisely ... a potential way to overcome hurdles in delivering cargo to the interiors of cells, where they could be used as an alterative technology for gene therapy, sa...

Iowa State scientists demonstrate first use of nanotechnology to enter plant cells

...e chemically activated to pop open and release the cargo inside of animal cells. This unique feature provides total control for timing the delivery The team’s first attempt to use the porous silica nanoparticle to deliver DNA through the rigid wall of the plant cell was unsuccessful. The technology had...

Biologists prove critical step in membrane fusion

Cells constantly swap cargo bound in vesicles, miniscule membrane-enclosed pac...e membranes? What do they look like before vesicle cargo is released? Wessel and his collaborators discovered that the membranes of the egg and the vesicl...

Walking molecule now carries packages

... be able to make one go around corners, rotate its cargo or send out photons to tell us where it is." The molecule carrier is anthraquinone, which consists of three fused benzene rings with one oxygen atom on each side. An organic compound, anthraquinone is widely used in the pulp industry for turning c...

Motor protein plays key role in connecting neurons

... at the Medical College of Georgia. Part of its cargo is DCC receptor which needs to move from the central nucleus where it's synthesized to the cell's periphery, Dr. Xiong and her colleagues report in the February issue of Nature Cell Biology and available online Jan. 21. At the periphery, DCC inter...

Molecular motors and brakes work together in cells

...is the train's engine, but the problem is that the cargo -- the molecular brakes -- gets longer, slowing down the daughter train. But when the train gets to the end of the track it remains attached to the end of mother microtubule. At the tail end, it stops moving and that defines the region of overlap. Ou...

Evolution of Old World fruit flies on three continents mirrors climate change

...merican West Coast in the early 1980s, probably on cargo ships. They spread rapidly, and in North America they are now found from near Santa Barbara, Calif., to northern Vancouver Island in British Columbia. The first samples of chromosome inversions were collected at several sites in Europe three to fo...

Think fast! Rice undergrad unlocks nerve speed secret

...y that the freight can be exported, but no outside cargo can enter. "With nerve cells, we've known that SNAREs provide the mechanical energy for membrane fusion, and another protein called synaptotagmin is the actuator," McNew said. "We also knew there was a chemical brake in the system, something that h...

Discovery of agile molecular motors could aid in treating motor neuron diseases

...er, they are responsible for transporting cellular cargo from the periphery of a cell toward its nucleus. ...t a "local delivery" motor, termed myosin V, moves cargo with a variable path short distances along another type of cellular track called actin. This flexibi...

New 'self-exploding' microcapsules could take sting out of drug delivery

...some other microcapsules, which release their drug cargo only when exposed to ultrasonic waves or another external trigger, the new system relies on internal mechanisms to do the same job. Each of the new microparticles features a biodegradable gel core that is surrounded by a lipid membrane. As the gel bi...

A new way of looking at molecular motors

...ck. Movement is created several ways. Biological cargo is transported within cells by single motors that run backward and forward, the way a person moves hand over hand along a rope. Making muscles contract involves a large number of motors that work very fast in neatly arranged teams, quickly letting go...

Swiss researchers develop all-in-one remote control gene expression tool

...its own genes, by way of RNA interference. But the cargo that makes this tool really novel and exciting is ...hion into the cell and is then part of its genetic cargo and part of the genetic cargo of all its progeny." The efficiency of the lentiviral vector will ma...

How the neuron sprouts its branches

... also used tracer molecules to track the molecular cargo secreted by the Golgi, said Ehlers. "We saw very clearly that this cargo that originates in the Golgi gets directed towards the one longest dendrite in a highly preferential...

Image of myosin-actin interaction revealed in cover story of Molecular Cell

...f the myosin protein family. It exists to ferry a cargo of proteins needed in a specific place at a specific time. Fueled by hydrolysis -- the process of converting the molecule adenosine triphosphate (ATP) into energy -- myosin V travels in one direction using actin as a track to deliver its payload of c...

Marathon of nano-sprinters

...shared by the pulling motors, strongly reduces the cargo velocity and leads to a highly nonlinear force-vel...olecular motors are nano-tractors for all kinds of cargo within the cells of living beings. They move in a stepwise manner along filaments of the cytoskeleto...

New technique could alter field of mouse genetics

...nserted into mouse embryos, the transposon and its cargo was inherited through five generations. PiggyBac can also be removed from its place in the family tree by breeding a mouse with another that carries the enzyme necessary to excise the jumping gene. "We do not know why the P element did not work in m...

Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development

...through which the virus unloads its deadly genetic cargo into the host cell does not open up right away; instead, a small pore can persist for several minutes before adopting its final size, or (in rare cases) closing permanently. This 'intermediate stage,' as the scientists describe this time interval, w...

Motor transport in bio-nano systems

... in this way, drive the heavy traffic of molecular cargo within biological cells. Both motors and filaments...port systems. In order to increase the flux of the cargo transport, it would be necessary to increase the number of motors that contribute to this transport ...

Researchers develop assay that could be applied to drug screening

...membrane, and one of the most important routes for cargo internalization is clathrin mediated endocytosis (CME). CME is of fundamental importance for many cellular activities including receptor down-regulation, nutrient uptake and maintenance of signal transmission across nerve cell junctions. Mis-regulati...

Shutting down the HIV assembly line

...n complex," a group of four proteins known to sort cargo proteins to specific compartments in the cell. Through a series of experiments, the group demonstrated that the AP-3 delta subunit interacts with Gag to direct it to the multivesicular body. Disruption of the interaction, using a specific piece of t...

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