cancers 2 4

Tag: "cancers" at biology news

Using nature's most primitive anti-viral defense system to find new approaches to cancer research

...is the cause of mortality in the majority of human cancers and it is a complex, multi-step process. Understanding the molecular mechanisms that underlie each stage is therefore an important goal for cancer scientists. Dr Baum's research builds on his earlier work when, in collaboration with others, he comple...

Evolution and the workaround

...t be particularly effective against pathogens and cancers adept at rapid drug resistance, the researchers say. To stay alive, you have to be both sturdy and flexible. The Stowers researchers look to these evolved yeast strains for future explanations of how the duplication of genetic information contri...

'Trojan Horse' agent halts bone metastasis in mice

...mors in bone, a common destination for a number of cancers when they start to spread. Researchers at The Uni...y it likely could help prevent the growth of other cancers in bones such as breast, multiple myeloma, lung and renal cell. "Many tumors invade bone in the s...

Report calls for improved monoclonal antibodies against solid tumors

...r Society, the researchers note that 85 percent of cancers involve solid tumors, but only 25 percent of approved antibody therapies are directed at solid tumor targets. The researchers suggest manipulation of the physical properties of a monoclonal antibody as a potentially effective way to improve antibody ...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

...are responsible for one form of lung cancer. These cancers can be treated with the targeted therapies Gleevec and Tarceva, respectively, which shut down the affected oncogenes. The test involves taking a sample of fresh or frozen tumor, amplifying its DNA, and then searching for 250 known mutations in 17 on...

Novel regulatory mechanism identified for key tumor suppressor p53

...s with such damage include cancer cells, since all cancers track to genetic flaws of one kind or another, whether inherited or acquired. If repairs cannot be made, p53 commands the cells with damaged DNA to self-destruct so they are no longer a danger to the body. This powerful ability of the p53 protein t...

Abnormal overexpression of p53 is a predictive molecular biomarker

...ation and chemotherapy treatment for head and neck cancers now has been found to predict a good prognosis wit...cancer, and about 11,000 patients will die. Many cancers have a dysfunction in the p53 pathway that regulates the cell cycle, helping to protect against canc...

UVa researchers seek to unlock broccoli's cancer fighting secret

... have the gene for this enzyme developed far fewer cancers when given carcinogens. "If we can determine th... liquid form could enhance the concept of stopping cancers before they start. For Cross, there is also a personal pull to developing anti-cancer compounds. ...

World's smallest cancer detection device

...microenvironments that appears crucial for causing cancers to spread," says Dr. Condeelis. "This five-year Tumor Microenvironment Network grant will allow Einstein to influence the way research is carried out in this emerging and important field." Dr. James Castracane, the project's co-investigator, who is...

Buildup of damaged DNA in cells drives aging

... disease characterized primarily by skin and other cancers rather than accelerated aging," said Dr. Hoeijmakers. "This patient, therefore, has a unique disease, which we named XPF-ERCC1, or XFE-progeroid syndrome." To understand why this XPF mutation caused accelerated aging, the investigators compared t...

Study offers innovative profile of enzyme that aids tumor growth

... "The heightened expression of KIAA1363 in several cancers indicates that it may be a critical factor in tumorgenesis. In addition, network components, including KIAA1363 itself, might be considered potential diagnostic markers for ovarian cancer." This experimental method of integrated molecular profiling ...

Long-term cancer risk follows stem cell transplant recipients

... their institution the 10-year incidence of second cancers in these patients was 3.1 percent. When nonmelanom...fter transplant. The most commonly reported second cancers were cancers of the skin (basal and squamous cell), lung, oral cavity, and colon. Furthermore, d...

Halving daily cigarette quota has no health benefit

... a day). Among men, deaths from lung cancer and cancers associated with smoking were not significantly lower in those who had cut back compared with heavy smokers. But this was not true of women who cut back, where the reverse was true. And men who cut back only had slightly lower death rates from all ...

MIT nanoparticles may help detect, treat tumors

...entually may be applied to many different types of cancers and to study the "triggers" that turn a benign mass in the body into a cancerous tumor. Nanoparticles also hold the promise of carrying medicines that could kill cancer cells, replacing radiation or chemotherapy treatments that cause negative side ef...

Jefferson scientists identify gene mutation potentially involved in breast cancer initiation

... present in approximately 19 percent of all breast cancers that are fed by estrogen ?so called "estrogen rece...ncers. As many as nearly 35 percent of such breast cancers may carry Caveolin-1 mutations, Dr. Lisanti says. Caveolin proteins, which play important roles in c...

Targeted virus compels cancer cells to eat themselves

...is virus replicates only in cancer cells.'' Other cancers are telomerase-positive, and the researchers showed in lab experiments that the virus kills human prostate and human cervical cancer cells while sparing normal tissue. In addition to demonstrating the therapeutic potential of the virus, called hTE...

Scientists resuscitate a 5 million-year-old retrovirus

...viral particles that can be observed in some human cancers such as germline tumors and melanomas," says Heidmann. "This work will be helpful in tracking down the role of retroviruses in these human diseases." ...

'Molecular assassin' targets disease gene

... of Nature Biotechnology. Certain types of skin cancers and blindness due to age-related macular degenerat...rug has already been shown to be effective on skin cancers in pre-clinical models, in another paper published this month by Professor Khachigian's team in the ...

Gene discovery opens door to tackling disease

...osterone in prostate cancer cells. "Most of those cancers depend on the hormones to stay alive, so if we can use SLIRP to block the hormones we may be able to help stop those diseases in their tracks." Professor Leedman said the discovery could open the door to targeted new treatments for the cancers. "If...

Drug dials down the energy within cells, UM researchers find

...lick believes. "There are other diseases---certain cancers and a number of other immune diseases---where we think the way the cells make and utilize energy is fundamental to the disease process. Combining that knowledge with our new knowledge of how to regulate the energy of the cell could open up new avenue...

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