cancers 2 10

Tag: "cancers" at biology news

Two designer drugs hit same lung cancer target, but only one is effective

...rinkage when they received Iressa, but none of the cancers responded to Erbitux. Janne says that the experiment told the scientists something new about the biology of the EGFR mutation in NSCLC. "The lesson is, to inhibit the mutant receptor, you need to inhibit the domain of the EGFR molecule that lies wit...

Change in gene may be underlying molecular defect in some colorectal cancers

...r, how the field defect may arise in most sporadic cancers in unclear. In colorectal cancer, the DNA repair ...s cells may prevent the development of new primary cancers in the same organ," they write. ...

Sleeping beauty plays a significant role in identifying cancer genes

...terature. Most of those identified are involved in cancers of the blood system. So, there are likely to be many more cancer genes that still need to be identified." Additionally, he noted that the Sleeping Beauty technology is capable of providing important information about the genes that current methods d...

IBM Transforms the Art of Scientific Expeditions

...erapy doubled the length of time it took for human cancers to begin growing again in mice, said the radiation biologists from the Duke Comprehensive Cancer Center. Each therapy alone had limited or no benefit on the tumor, because tumors are skilled at circumventing individual therapies and finding new ways...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...erapy doubled the length of time it took for human cancers to begin growing again in mice, said the radiation biologists from the Duke Comprehensive Cancer Center. Each therapy alone had limited or no benefit on the tumor, because tumors are skilled at circumventing individual therapies and finding new ways...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...pproved for the treatment of metastatic colorectal cancers that overexpress EGFR. Cetuximab targets EGFR by preventing its activation by extracellular signals, or signals occurring outside of the cell, as opposed to the intra-cellular signal blocking of drugs like gefitinib. The researchers treated seven ...

Slipping past the blood brain barrier: Research shows potential treatment for brain cancer

...enter in St. Louis. "Most of our drugs that fight cancers are toxic to cancer cells and to other cells, too. That's why the blood brain barrier locks them out of the brain." The research was done in collaboration with investigators at Tulane University School of Medicine in New Orleans, including Nobel Lau...

Mass production of human papillomavirus could lead to gains against cervical cancer

...pes contribute to about a quarter of head and neck cancers and some skin cancers. A more common, less virulent form of the virus causes genital warts. Using the new technique scientists can quickly produce a thousand times more infectious virus per culture dish than they could using conventional methods. Re...

Fruit fly studies open new window on cancer research

...lead to a completely new approach to tackling some cancers and the development of new drugs to stop uncontrolled growth in a wide variety of tumour cells. The researchers at the University of Oxford, funded in part by the Biotechnology and Biological Sciences Research Council (BBSRC), discovered that this f...

Biased reporting found in cancer prognostic studies

...ed meta-analyses on prognostic factors for various cancers did not use the same standard end point definitions, and 89% of them failed to retrieve all of the data from the individual studies, instead including only a sample. Both of these details may have helped to fabricate the strong prognostic factor/canc...

Most common lung cancers may begin in newly discovered cells

...her scientists have found evidence that some human cancers contain a small but virulent group of cells known ... about one-third of all tested non-small cell lung cancers in people. A specially designed virus can activate the mutation in only a few cells. The mouse is kn...

Unraveling a stomach cancer puzzle

..., the gene differences identified in human stomach cancers are similar to those we would predict if the same thing, Stat3 hyperactivity shutting down TGF, happens in humans. So this is also the first time a connection between stomach cancer and this signaling pathway has been made." Team leader Dr. Matthias...

Major breakthrough in the treatment of cancers and infectious diseases

... that could significantly advance the treatment of cancers and infectious diseases. Current treatments freque...eficiency is associated with a higher frequency of cancers and serious infections. Dr. Veillette's breakthrough demonstrates that a molecule known as EAT-2, pr...

Scientists inhibit cancer gene

... gene that has been shown to promote the growth of cancers in the pancreas, colon and lung, as well as thyroid cancer and leukemia. Attempts to inhibit activated Ras have had limited success until now, but the Huntsman Cancer Institute researchers explain that they have discovered an enzyme that, when inhib...

High-powered gene profiles provide clues to genes involved in common form of lung cancer

... (NSCLC) accounts for about 75 percent of all lung cancers and is responsible for nearly 120,000 deaths in th... country annually. It is one of the most difficult cancers to treat, with only 15 percent of patients surviving more than five years after diagnosis. In recen...

FDA Approves New Treatment for Chronic Hepatitis B

... of Baraclude (entecavir) to evaluate the risks of cancers and liver related complications. ...

Natural tumor suppressor in body discovered by UCSD medical researchers

...PP's role as a tumor suppressor would apply to all cancers where Akt is elevated, "which is a large number of cancers," Newton said. ...

U of T researchers map role of Epstein-Barr virus in cancer

...the world and is strongly linked to certain b-cell cancers like Burkitt's lymphoma as well as the epithelial cell cancer, nasopharyngeal carcinoma. EBNA1 is a protein coded in the Epstein-Barr virus and suspected to play a role in the development of cancer," says Lori Frappier, professor in medical genetics ...

NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma

...enced a significant reduction in the size of their cancers as a result of receiving a new immunotherapy. This immunotherapy consisted of a combination of chemotherapy and reintroduction of their own (autologous) activated lymphocytes. Autologous lymphocytes are white blood cells that have been removed from t...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...nd thus is widely used to treat and prevent breast cancers that depend on estrogen. But it has the opposite e...sequence, GW 5638 can inhibit the growth of breast cancers that have become resistant to tamoxifen. It may also be more effective than tamoxifen at preventing ...

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