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Tag: "cancerous" at biology news

Once given 'no respect,' cells' tiny RNAS take driver's seat

...e potential to very potently drive cell growth and cancerous proliferation." Among the genes Myc controls is one called E2F1, which, like Myc, also controls the expression of genes. One of the genes controlled by E2F1 just happens to be the gene for Myc. "This establishes a feedback loop," says Kathryn O'Don...

Energy management in cells may hold key to cancer defense

...'s results could signal new advances for combating cancerous tumor growth, but also type 2 diabetes and obesity. The study, published in the August 12 issue of the Journal of Biological Chemistry (JBC), was headed by Dr. Lee Witters, Eugene W. Leonard 1921 Professor of Medicine and Biochemistry at DMS and of...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

... introduced individually or in combination, led to cancerous growth. But when a mutant form of Ras--produced by an oncogene that sends growth signals to a cell--was added to this combination, it produced clinical features of invasive human melanoma: darkly pigmented skin that progressed to ulcerated tumor nodu...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

... introduced individually or in combination, led to cancerous growth. But when a mutant form of Ras--produced by an oncogene that sends growth signals to a cell--was added to this combination, it produced clinical features of invasive human melanoma: darkly pigmented skin that progressed to ulcerated tumor nodu...

Engineered skin offers clues to melanoma development

... introduced individually or in combination, led to cancerous growth. But when a mutant form of Ras--produced by an oncogene that sends growth signals to a cell--was added to this combination, it produced clinical features of invasive human melanoma: darkly pigmented skin that progressed to ulcerated tumor nodu...

Slipping past the blood brain barrier: Research shows potential treatment for brain cancer

...- releasing hormone, which has been found to cause cancerous tumors, such as malignant glioblastomas, to grow. The main known purposes of the hypothalamic growth hormone-releasing hormone usually are to trigger the hormone that makes children grow and affect how glucose is used in adults. Researchers found ...

Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors

... a target for studying both normal development and cancerous growth, said Lee. Other research teams have shown that certain genes are mutated in medulloblastoma, but it has not been clear in which particular cells these genes are mutated. The Duke team hopes to develop animal models in which they alter genes ...

Nanoparticles carry cancer-killing drugs into tumor cells

...ssue, cells grow and divide - this is also true of cancerous tumors. The difference between the two lies in the regulation, which functions well in healthy tissue, but not in tumors. An important mechanism of this regulation is programmed cell death, known as apoptosis. It causes the controlled death of single...

Missing Receptor Molecule Causes Tumor Growth

...ssue, cells grow and divide - this is also true of cancerous tumors. The difference between the two lies in the regulation, which functions well in healthy tissue, but not in tumors. An important mechanism of this regulation is programmed cell death, known as apoptosis. It causes the controlled death of single...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

... may choke off a tumor's blood supply and kill the cancerous cell. Varner and her team found that a specific integrin protein called alpha4beta1 was produced at high levels in one part of a developing blood vessel, the interior area called the endothelia. The integrin was not produced in mature blood vessels,...

Gov't Creates Gene Database of Normal Human Tissues

... to compare cells and tissue they suspect may have cancerous or other malfunctioning genes. To create these fingerprints, Khan and his team assembled a complementary DNA (cDNA) microarray, using a pair of glass slides on which thousands of known genes have been printed in tiny spots. Cells can be tested by man...

Different microarray systems more alike than previously thought

...ver critical differences between, say, healthy and cancerous tissue. Unless laboratories can rely on each others' results, such findings would not have much value. For the study, 10 laboratories in the Washington, D.C./Baltimore area were given identical samples of RNA -- DNA's cousin -- to analyze using a mi...

PET/CT can identify new cancer lesions at early stage, allowing for prompt treatment

...help physicians identify new, unexpected malignant cancerous tumors in patients, according to an article in the May issue of the Society of Nuclear Medicine's Journal of Nuclear Medicine. "PET/CT can help find additional lesions in patients known to have cancer," said SNM member Richard L. Wahl, M.D., directo...

Yeast Network Prevents Damage By Oxygen Radicals

...control mechanisms are important guardians against cancerous changes in human cells," says Dr. Richard Kolodner, LICR Member and senior author of the study. "However, the effects of ROS on these cellular responses have not been well characterized. We've now identified a group of genes that cooperate to suppres...

Anti cancer virotherapy well tolerated in first human administration, research finds

...stration of a single dose of CVA21 directly into a cancerous tumour was well tolerated. "Administration of CVA21 may be of potential therapeutic benefit in controlling the spread of melanoma," Professor Shafren said. CVA21 is one of a small group of naturally occurring rather than genetically modified viruse...

Nanoparticles offer new hope for detection and treatment

Specially designed nanoparticles can reveal tiny cancerous tumors that are invisible by ordinary means of det...as they carry the imaging materials that spotlight cancerous growth. "One of the best advantages of the particles is that we designed them to detect tumors usin...

Defensins neutralize anthrax toxin

...ansforms human B cells from the immune system into cancerous cells, which can lead to development of B-cell lymphomas. Erle S. Robertson, PhD, Associate Professor of Microbiology and Director of Tumor Virology, with Penn's Abramson Cancer Center and MD/PhD student Jason Knight, published their results in the ...

Epstein-Barr virus protein crucial to its role in blood cancers

...ansforms human B cells from the immune system into cancerous cells, which can lead to development of B-cell lymphomas. Erle S. Robertson, PhD, Associate Professor of Microbiology and Director of Tumor Virology, with Penn's Abramson Cancer Center and MD/PhD student Jason Knight, published their results in the ...

Pulsating ultrasound enhances gene therapy for tumors

...-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according...inuous exposures that raise the temperature inside cancerous cells, effectively "cooking" them. Under a technique introduced by King C.P. Li, M.D., M.B.A., from ...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

...e isotopes specifically seek out, bind to and kill cancerous cells. Provided that you can find something different on the cell surface between normal and cancerous cells; this is not as easy as it sounds. A new form of treatment for lymphoma that takes a fractio...

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