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Tag: "cancerous" at biology news

Cells re-energize to come back from the brink of death

...Previous research has shown that cells that become cancerous lack caspase and other proteins needed to support ...is short-lived if CICD is activated. However, some cancerous cells not only dodge death from apoptosis by eliminating caspase activation, but they also foil CIDC...

Catching cancer's spread by watching hemoglobin

...oring tumors, because the oxygenation state around cancerous tissue and the size and density of blood vessels around the tumor can provide a lot of information about the progression of a tumor and its response to anti-cancer drugs. In the technique, two lasers at different wavelengths (colors) send ultra-sh...

How to steer a moving cell

...e also found to control the movement of normal and cancerous cells," said Klemke. "This is apparently a fundamental, evolutionarily conserved process in migrating cells. So it clearly has an important purpose to the cell." A network of proteins called the cytoskeleton, the cell’s internal scaffolding, d...

Gene thought to assist chemo may help cancer thrive

...erapy. The idea is that p53 assists in killing the cancerous cells that the chemo treatment injures. But in this latest trial, Georgia Tech researchers found that p53 may be a “double-edged sword.?Chemotherapy patients whose tumors had a mutated p53 gene that didn't work had a much better survival rate tha...

Growing nerve cells in 3-D dramatically affects gene expression

...fman-Kim and researchers in her lab took a line of cancerous nerve cells and cultured them in different environments. They placed one batch of cells in standard petri dishes coated with collagen. They suspended the other batch in a thicker collagen gel. The bioengineers took great pains to be sure that this on...

Intelligent materials to regenerate bone tissue

...o congenital deficiencies, degenerative illnesses, cancerous disorders and other damage caused by accidents. The implants required for this type of solutions are more complex and sophisticated than the small implants known to date. . The Nanobiocom project aims at developing a support matrix (scaffold) of a...

It's never too late to get it back! Aging interrupted

... to search for drugs which cause pre-cancerous and cancerous cells to commit suicide and to replace those cells with new, healthy cells. It is thought that the body does this because it normally kills some cells like damaged and rogue cancer cells to provide energy when it is starving. Then it replaces these...

Investigating the measles virus as a tool to kill multiple myeloma

... were observed to cause regression of pre-existing cancerous tumors in children. This information was noted, but nothing was done to study this phenomenon until the late 1990s, when, under the direction of Stephen Russell, M.D., Ph.D., Mayo Clinic Cancer Center’s Molecular Medicine Program began investigating ...

Scientists identify pancreatic cancer stem cells

... in pancreatic cancer, the research team implanted cancerous tissue from human pancreatic specimens removed during patient surgery in "xenograft" mice with compromised immune systems. Researchers removed tumors after they grew, and then sorted millions of cancer cells to isolate those that had one or more of t...

Major gene study uncovers secrets of leukemia

...t why progenitor cells get stuck in the primitive, cancerous stage, the more likely we'll be able to design new therapies that eliminate them. That could help us continue our successful efforts to increase the survival rate of ALL." One potential strategy for eliminating leukemic cells would take advantage...

Veterinary scientists explore poultry virus as cancer killer

...cific antigen (PSA), which is found exclusively in cancerous prostate cells. Normal, healthy cells have an interferon antiviral system that activates upon infection with NDV thereby preventing replication of the virus, explains Dr. Subbiah. Cancer cells, however, have defective interferon antiviral systems...

Genes set scene for metastasis

...rous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake distant organs. A number of genes are already known to contribute to the spread of breast cancer cells to the lungs. Using genetic and pharmacological approaches, Joan Massagué, PhD, Chair of ...

A genetic 'gang of 4' drives spread of breast cancer

...ors. Cooperation among the four genes also enables cancerous cells to escape into the bloodstream and penetrate through blood vessels into lung tissues. Although shutting off these genes individually can slow cancer growth and metastasis, the researchers found that turning off all four together had a far more...

Cancer-killing invention also harvests stem cells

... locations in the body, where they form secondary, cancerous growths. As a cancer cell flows along the implanted surface, King's device captures it and delivers an apoptosis signal, a biochemical way of telling the cancer cell to kill itself. Within two days, that cancer cell is dead. Normal cells are le...

New protein inhibitor impedes growth of cancerous cells

... BI 2536 can indeed effectively halt the growth of cancerous cells, both in cell culture and in an animal model for human tumor growth. BI 2536 caused growth arrest and cell death in cell lines derived from a variety of human cancers, and it inhibited the growth of human tumor grafts in mice, resulting in the ...

Molecular differences between early and advanced melanomas could provide new drug targets

...e growth of microscopic blood vessels that nourish cancerous tumors and lead to unregulated cell growth. When melanoma cells overexpressing Akt were introduced into immunocompromised (nude) mice, the mice developed aggressive tumors that expressed high levels of VEGF, whereas a control group of mice developed...

Scientists discover how body fights to control spread of cancer

...ctive shield of a protein called MUC1 in which the cancerous cells are eventually destroyed by our immune system. Scientists have now discovered how this protective shield is broken down, allowing cancer to spread throughout the body. Dr Lu-Gang Yu, from the University's School of Clinical Sciences, explain...

UCSF brain tumor vaccine trial shows promising results

...ifornia, San Francisco. Known as a glioma, this cancerous tumor is always fatal. Findings from a group of 12 study patients showed that vitespen vaccination (trademarked as Oncophage) was effective in stimulating the patient’s immune system to attack the tumor cells, a function that is known medically as...

Cancer vaccines -- Taking a jab at cancer by stimulating the immune system

...an effort to coax the immune system into attacking cancerous cells. Today at the 2007 Annual Meeting of the American Association for Cancer Research, presentations on ongoing HPV trials and other new approaches to stimulating the immune system are injecting momentum into cancer vaccine research. Substantia...

Researchers first to map gene that regulates adult stem cell growth

...gene plays in transforming healthy stem cells into cancerous ones, such as in leukemia and lymphomas. If the gene does in fact play such a role, it is possible that it also could provide the keys to new therapies. Van Zant describes his discovery as an elation. He worked on the project for six years with Yin...

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