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Tag: "cancer" at biology news

DNA Molecules Used To Assemble Nanoparticles

...particle complexes can be specifically targeted to cancer cells and are small enough to enter a diseased cel...e designed for imaging and the other for targeting cancer cells. Each of the dendrimers also carried a single-stranded, non-coding DNA synthesized by Choi. I...

Viral DNA sequence a possible trigger for breast cancer

...irus (called MMTV) can transform breast cells into cancer cells, according to a study by Katz et al. in the ...arcoma virus, but what role this sequence plays in cancer development has remained unexplored. Katz and colleagues now show that this sequence is contained i...

Association of herpesvirus with lung disorder questioned

...ion is associated with Kaposi's sarcoma, a type of cancer most commonly seen in some parts of Africa and southern Europe and in people infected with HIV. Primary pulmonary hypertension is characterized in part by vascular lesions in the lung, and may lead to heart failure. Some cases are associated with gen...

Man and mouse share genome structures

...ntists understand regulatory mechanisms underlying cancer and human development. The research team includes first author Bradley Bernstein, recipient of a Howard Hughes Medical Institute (HHMI) physician postdoctoral fellowship who works in the Harvard University laboratory of HHMI investigator Stuart L. S...

Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer

For patients with high-risk breast cancer treated with radical mastectomy and adjuvant chemo...iation therapy was associated with improved breast cancer survival but not with overall survival. In this 20-year follow-up of the British Columbia trial, Jo...

Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down

For patients with high-risk breast cancer treated with radical mastectomy and adjuvant chemo...iation therapy was associated with improved breast cancer survival but not with overall survival. In this 20-year follow-up of the British Columbia trial, Jo...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...n fat cells and metabolic pathways in diabetes and cancer at Dana-Farber. "It offers the opportunity to try to understand what makes these fatty acids so deleterious, and what we need to avoid." Moreover, it is possible that in the future, drug therapy might be used to "turn down" the mechanism, decreasing...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...own as bulky DNA adducts is associated with breast cancer risk, Regina M. Santella, Ph.D., of the Columbia U...in which one sister had been diagnosed with breast cancer and the other had not. They found that DNA repair capacity was lower in breast cancer patients than...

Source of molecular triggers in cutaneous T cell lymphoma identified

...lity to manage a spectrum of maladies ranging from cancer to disorders of immune regulation," said Edelson. ..."Inhibiting Treg-cell generation may be useful for cancer immunotherapy and promoting Treg development may be useful to induce tolerance in autoimmune disease...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...y, this discovery should expand attention in colon cancer research to earlier events, situations present wel... or so Johns Hopkins patients with suspected colon cancer suggests that IGF2's effect in people may be similar, the researchers report. A larger study of samp...

Columbia research lifts major hurdle to gene therapy for cancer

... to kill normal cells in theprocess of eradicating cancer cells.In a new study published in the Jan. 25 issu...ially designedvirus. The virus eradicated prostate cancer cells in the lab and inanimals while leaving normal cells unscathed. Genetherapy based on the new t...

New, automated tool successfully classifies and relates proteins in unprecedented way

...mor cell's machinery needed toprocess proteins for cancer growth."Our tool represents a step forward because it is based on standardizedfeatures and not on features chosen by the human eye, which isunreliable. By automating the clustering of proteins inside cellimages, we also can study thousands of images ...

New binding target for oncogenic viral protein

...cancer. This is an important step to designing new cancer treatment strategies that target these pathways," concluded Dr. Clurman. ...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

...perimental test intended to identify early ovarian cancer from a small sample of blood is unlikely to lead t...pears to be the case with the experimental ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study re...

New species from old data

...perimental test intended to identify early ovarian cancer from a small sample of blood is unlikely to lead t...pears to be the case with the experimental ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study re...

Cracking the olfactory code in bees

...perimental test intended to identify early ovarian cancer from a small sample of blood is unlikely to lead t...pears to be the case with the experimental ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study re...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...between labs. Twelve different tumor tissues, five cancer celllines, and five purified RNA samples were prepared, blinded, andrandomized for analysis in four laboratories: University of MichiganMedical School, Ann Arbor, Mich.; Dana Farber CancerInstitute/Whitehead Institute, Boston, Mass.; Memorial Sloan-K...

Signaling protein builds bigger, better bones in mice

...perimental test intended to identify early ovarian cancer from a small sample of blood is unlikely to lead t...pears to be the case with the experimental ovarian cancer test at issue, which was first proposed in 2002 by researchers in the journal, Lancet. That study re...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

... "immortal" (able todivide indefinitely) aspect of cancer cells. Yet, something in the cellseems to block th...about how to boost the effectivenessof a promising cancer treatment that targets telomeres in an attempt tointerfere with the ability of a cancer cell to cont...

GATA: a graphic alignment tool for comparative sequence analysis

... "immortal" (able todivide indefinitely) aspect of cancer cells. Yet, something in the cellseems to block th...about how to boost the effectivenessof a promising cancer treatment that targets telomeres in an attempt tointerfere with the ability of a cancer cell to cont...

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