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Tag: "built" at biology news

New hybrid virus provides targeted molecular imaging of cancer

... series of studies by Pasqualini and Arap that are built around their discovery that the human vasculature system contains unique molecular addresses. Organs and specialized tissues also have specific "zip codes" on their blood vessels, as do tumor blood vessels. Knowing this, Pasqualini and Arap designed,...

Study in Science holds promise for a new approach to drug therapy

...signals inside them. Proteins called receptors are built into the outer cell surfaces and designed to react with a single, specific signaling molecule (a ligand). When a signaling molecule docks into the receptor and binds to it, like a ship coming into port, it changes the shape of the dock in a such a wa...

Oh, rats! Designer animals reveal possible heart disease genes

...nes behind heart disease. In total, the scientists built 2,200 microarray gene expression profiles from these designer rats--providing a valuable new online resource now available to researchers worldwide. Scientists have long used rat models to study heart disease in the lab. But those studies have yet t...

Molecule by molecule, new assay shows real-time gene activity

... current understanding of this two-step pathway is built upon their averaging of genetic and biochemical activity across large populations of cells and molecules, masking the essential randomness of the process at the cellular level. Furthermore, much of our knowledge on the workings of the molecular machi...

Neuroscientists discover new cell type that may help brain maintain memories of smells

... The multiphoton microscope used in this study was built by Strowbridge specifically for these types of experiments and was funded by grants from the Mt. Sinai Health Care Foundation and the National Institutes of Health. Strowbridge and Pressler highlighted two distinct set of experiments they hope to p...

Basic research leads to a novel cancer therapy

...s, nerve tissue, and connective tissue - are to be built up during the development of an organism and in the process of tissue regeneration. Research has focussed on these tumour cell signalling cascades, because in cancers they are often disturbed. If there were a way to block growth factors, or the rece...

Penguins waddle but they don't fall down, UH researchers say

...ns, have large, expensive and cumbersome computers built onto their "bodies" to keep them from tipping over when they walk and run. His research can be used to build smaller computers for such robots that will become increasingly more life-like. "There is not much research on this issue, so we're hopefu...

Georgia Tech accelerates drug discovery with new IBM supercomputing cluster

... factor of 10." The 1000-node Cluster 1350 system built on IBM BladeCenter® systems and powered by dual-core AMD Opteron TM processors is capable of performing more than 8.5 trillion calculations per second, which would place it as the world's 41st most powerful supercomputer based upon the November 2005...

Bone and cartilage growth to blame for heart valve disease

...deposits of calcium, a mineral found in the blood, built up on the valves. Therefore, research has never focused on preventing the problem," says Dr. Rajamannan. "Currently the only option is to surgically repair or replace the damaged valves. Our findings open the door to the idea that medical therapie...

Anemone genes reveal versatile building blocks for body plans

... learn how different body plans are determined and built at the molecular level, and how they arose during evolution. The work is reported in the March 7th issue of Current Biology by David Matus and colleagues at the University of Hawaii and Stony Brook University. To understand the evolution of body-p...

Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

...ing the disease. "Myelination, a process uniquely built up in humans, arguably is the most important and most vulnerable process of brain development as we mature and age. These new findings offer, for the first time, compelling genetic evidence that myelin breakdown underlies both the advanced age and th...

What's shaped like a pear and has 2 genomes? Check the pond

...t degrade proteins), for instance, Tetrahymena has built an eating machine that allows it to digest nearly any protein it encounters. Among its most quirky features, Tetrahymena has, inside each of its cells, two distinct nuclei, each with a different genome. Inside one nucleus, the "micronuclear" genome...

Bones hold the key to blood renewal

...e, the osteoclasts demolish bone faster than it is built up. This study suggests the effects of such an imbalance may reach well beyond the bone. ...

Robotic joystick reveals how brain controls movement

... the May 23 issue of PLoS Biology, the researchers built on their observations that some parts of the brain learn - and forget - fast, while others learn more slowly and more lastingly. Both types of learning are critical. "We believe our work is the first to show that motor learning involves different ti...

New approach to vaccine development provides potent, long-lasting immunity

... the May 23 issue of PLoS Biology, the researchers built on their observations that some parts of the brain learn - and forget - fast, while others learn more slowly and more lastingly. Both types of learning are critical. "We believe our work is the first to show that motor learning involves different ti...

Sandia work launched on space shuttle shows live cells influence growth of nanostructures

...ls) customize the construction of nanocompartments built for them. These nanocompartments - imagine a kind of tiny apartment house - form when single cells are added to a visually clear, aqueous solution of silica and phospholipids, and the slurry is then dried on a surface. (Phospholipids are two-sided ...

Hopkins researchers develop new tool to watch real-time chemical activity in cells

... disease. In the course of their work, the team built a protein biosensor that indicates if an enzyme located nearby is turned on or off. The sensor is made from a protein that glows, originally isolated from jellyfish. When PKA is turned off, the biosensor glows blue. When PKA is turned on and is physi...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

... part to a custom-made bioreactor that researchers built in their laboratory; it has the capability of delivering controlled chemical, electrical and mechanical stimulation to the stem cells. Bioreactors have been used for centuries as fermentation chambers for growing organisms such as bacteria and yeast,...

New light microscope sharpens scientists' focus

...la, California. There, in just two months, they built a prototype of the instrument. They also understood, however, that the biology and sample preparation issues would loom just as large as the instrumentation ones. So they contacted Davidson at FSU and Lippincott-Schwartz and Patterson at NICHD. Soon,...

Federal testing for mad cow disease a failure, law review editor says

...attle for BSE using a $500,000 testing site it had built to USDA specifications. But the agency ruled that the BSE test was licensed only for "surveillance" of animal health, and rejected Creekstone's request because it implied "a consumer safety aspect" that was "not scientifically warranted." The agenc...

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