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Tag: "buildup" at biology news

Parkinson's disease mechanism discovered

...ormalities in alpha-synuclein could cause a lethal buildup of the protein in neurons. Researchers also knew t...alpha-synuclein accumulation could cause the toxic buildup of dopamine to occur in these neurons." Lindquist and her colleagues believe their findings will gu...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...ene are not executed properly, leading to a lethal buildup of malformed proteins in brain cells. The new s...n Laboratory point to a novel mechanism behind the buildup of the toxic sludge that accumulates in neurons. Researchers have long known that neurodegenerative ...

Corals switch skeleton material as seawater changes

... is changing in response to global warming and the buildup of carbon dioxide in the atmosphere. A 2005 Ph.D. graduate of Johns Hopkins, Ries collaborated on the research with his dissertation advisors, Steven M. Stanley (now of the University of Hawaii) and Lawrence A. Hardie, professor in the Morton K. Bla...

Gene linked to rare disease activates fat breakdown

...nt version of the gene, suffer from the widespread buildup of fat in tissues throughout their bodies. The group found that the gene "CGI-58" is a strong activator of one of three lipid-degrading enzymes, or lipases, that disassemble triacylglycerol. Triacylglycerol is perhaps more commonly known as triglyce...

ABCB6 is key to production of heme in hemoglobin

...e such group of diseases is cutaneous porphyria, a buildup of porphyrins that causes the skin to blister and swell in sunlight; and acute porphoryia, a nerve problem that triggers pain in the chest, abdomen, limbs or back, as well as paralysis, cramping and personality changes or mental disorders. "Also, peo...

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

...ility of treating vascular inflammation and plaque buildup through the transfer of protective genes. "There...bout a 25 percent decrease in the amount of plaque buildup in the animals' aortas and other vessels. Apo A-I Milano gene transfer resulted in a 65 percent redu...

Seals protect brain, conserve oxygen by turning off shivering response on icy dives

..., seals maintain aerobic metabolism, avoid lactate buildup that occurs in the face of insufficient oxygen and require little time to recover, Folkow explained. Seals often spend 80-90% of their time at sea underwater, he said. Seals in the wild occasionally dive for so long that they use nearly all their ...

Hopkins scientists link immune response to 'ghost' parasites and severely congested sinuses

...ce of its corresponding enzyme and its role in the buildup of mucus and fluids, and polyp formation makes the enzyme a legitimate target for drug therapies to block its production and action. "If we can selectively shut down the antiparasite immune response, we could potentially have new treatments for t...

New study finds chocolate chip cookies lower cholesterol

...ased formation of fatty substances and cholesterol buildup in the arteries, even for individuals with total cholesterol levels under 200 mg/dl. The randomized, double blind study researched 33 healthy adults with moderately high cholesterol between the ages 35?5 at the University of Connecticut, Storrs, CT...

NASA satellite data helps assess the health of Florida's coral reef

... data was also used to measure the cumulative heat buildup over several weeks, shown to be particularly important to the health of reefs. "MODIS imagery is beneficial because it provides more detail than traditional satellites, allowing us to detect conditions down to hundreds of meters - the size of indiv...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...s from lung cells to airways causes thick mucus to buildup inside the lung. The finding suggests a new therapeutic target for treating lung infections in some cystic fibrosis (CF) patients. Lung infection, facilitated by CF mutations, is the main cause of death in CF patients. This bacterial component to ...

Protein sensor for fatty acid buildup in mitochondria

...detectors, cells have an enzyme that responds to a buildup of fatty acids by triggering the production of a k...y binds tightly to PanK2, shutting it down. When a buildup of fatty acids occurs in the cell, a molecule called carnitine shuttles them into the mitochondria. ...

Power-boosting signal in muscle declines with age

... in their seventies show a higher incidence of fat buildup in their muscle and livers and a deficiency in mitochondrial function, Shulman explained. These metabolic shifts have been implicated in the increased prevalence of insulin resistance and type 2 diabetes that occurs with aging. "The message of thi...

UCF nanoparticle offers promise for treating glaucoma

...loss. High pressure occurs, in part, because of a buildup of carbon dioxide inside the eye, and the compound blocks the enzyme that produces carbon dioxide. Seal and a team of collaborators including Sanku Mallik, of North Dakota State University, developed the research on using nanoparticles as a delive...

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