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Tag: "buildup" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

... molecular chain of events from eating fats to the buildup of cholesterol and triglycerides in the blood were unknown. "What we have found is a missing link, a mechanism by which saturated fats and trans fats can do their dirty work," said Spiegelman, who carries out basic research on fat cells and metaboli...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...ntroduce the functioning gene and correct glycogen buildup in heart and skeletal muscle. The findings suggest that such an approach should be considered as a potential gene therapy strategy for Pompe disease patients, the researchers report in a forthcoming issue of Molecular Therapy (now available online). ...

Poplar trees redirect resources in response to simulated attack

...ovision of long-term storage of carbon so that the buildup of carbon dioxide in the atmosphere will be reduced. IMAGES/CAPTIONS: http://www.bnl.gov/bnlweb/pubaf/pr/photos/2005/D3150503_FERRIERI-300.jpg Richard Ferrieri (L) and co-author Dennis Gray, now with the University of Connecticut, position a plant l...

Researchers discover molecule that causes secondary stroke

...tment researcher Joseph Clark, PhD, results from a buildup of toxins caused by bleeding from the initial stroke. "Normally the cerebral spinal fluid that envelopes the brain carries off wastes and exchanges them for nutrients at what's called the blood-brain barrier," Dr. Clark says. "After a hemorrhagic str...

Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers

...r bodies is equally important to prevent its toxic buildup in tissues. "Even in our own case, our bodies have to supply oxygen to our tissues, but they must also keep out excess oxygen to prevent oxidative damage to the tissues. This damage is closely related to aging. Hence, perhaps, the many anti-oxidative...

Gene vaccine for Alzheimer's disease shows promising results

...r's disease, immunization with amyloids slowed the buildup ofplaque in the brain and appeared to slow cognitive loss."Although human clinical trials are still at least two years out,theoretically, we are on the right track," he said....

Scientists identify molecular events that drive cell senescence

...r's disease, immunization with amyloids slowed the buildup ofplaque in the brain and appeared to slow cognitive loss."Although human clinical trials are still at least two years out,theoretically, we are on the right track," he said....

Implanted Devices Detect High-Risk Heart Failure Patients

...blood vessels (ACE inhibitors)or remove the excess buildup of fluid in the lungs (diuretics). Implantable devices are the latest options in preventing arrhythmias that can lead to sudden death, with CRT-Ds being the latest technology. CRT-Ds perform two main functions. First, the devices electrically stimul...

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

.... The AIM-protected macrophages go on to encourage buildup of fats on the interior walls of arteries, accordi...raging other cells to accumulate and worsen plaque buildup in arteries. "The oxidized lipids are cleared out by macrophage cells, but the lipids themselves ar...

Pinpointing the cause of a neurodegenerative disorder

...age to cerebellar Purkinje cells caused by a toxic buildup of the protein Ataxin-1. Researchers knew that SCA... on the type of disease. In SCA1, for example, the buildup of Ataxin-1 damages the cerebellar Purkinje cells. As a result of the damage, people with SCA1 lose ...

Study shows eutrophic lakes may not recover for a millennium

...r reported results of a study that showed that the buildup of phosphorus in soils in lake watersheds is likel...ld's leading authorities on freshwater lakes. "The buildup of phosphorus in watersheds is very threatening. Sooner or later it is going to hit the lakes and it...

Errors in the measurement of global warming corrected

...ded the surface warming has partly resulted from a buildup of greenhouse gases in the atmosphere. The key to the error in climate change estimates lay in instrument design, according to this study. With exposed sensors, measurement taken in daylight read too warm, and while solar heating had a measurable im...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...such as liver problems, swollen lungs and a severe buildup of fluid in the chest and peritoneal cavities. Perhaps even more impressive was the improvement in endurance and lifespan of the treated versus the untreated hamsters. The AAV-8-treated hamsters were able to run the same distance as normal hamsters ...

Molecular cabal contributes to stroke damage

..., the cutoff of oxygen kills brain cells through a buildup of acid, as well as by overexciting receptors on the surface of brain cells. Now, researchers exploring the detailed mechanism of this excitotoxicity and acidotoxicity have discovered how an insidious chain of molecular events contributes to its dama...

A new focus for the mechanism of nerve growth

... assembly, recycling is necessary to prevent actin buildup that could actually impede neuronal advance." Forscher likened actin networks in the growth cone to a molecular treadmill that is constantly being assembled at the leading edge and moved rearward, powered by a myosin II motor located at its back end...

Scientists discover basic defect in cystic fibrosis airway glands

...ts at Stanford University have determined that the buildup of sticky mucus found in cystic fibrosis is caused by a loss in the epithelial cell's ability to secrete fluid. This research appears as the "Paper of the Week" in the March 17 issue of the Journal of Biological Chemistry, an American Society for Bi...

Intensive statin therapy may partially reverse plaque build-up in arteries

... a statin drug can regress (partially reverse) the buildup of plaque in the coronary arteries. This findin...HDL, can regress, or partially reverse, the plaque buildup in the coronary arteries." Dr. Nissen will present the results of the "Effect of Very Low LDL-C Lev...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

...educes both of the pathologies--the brain-clogging buildup of protein "amyloid plaque" outside brain cells and the protein "neurofibrillary tangles" inside the cells. In an article in the March 2, 2006, issue of Neuron, Dr. Frank LaFerla of the University of California, Irvine and his colleagues reported t...

Johns Hopkins lab scientists tame overactive CF protein

...loride is the hallmark of CF that causes dangerous buildup of thick, sticky mucous in several organs, including the pancreas and the lungs, leading to malnutrition, chronic lung infections and lung damage. Cells have a built-in quality-control machinery called ERAD (endoplasmic reticulum-associated degradat...

U of M study examines kidney stone prevention in astronauts

...ost common types of kidney stones is caused by the buildup of calcium oxalate. Researchers studied the effects of exercise in pairs of identical twins, since a portion of a person's risk for developing kidney stones is genetic. The study participants had no history of kidney stones and were placed on standa...

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