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Tag: "broadly" at biology news

New binding target for oncogenic viral protein

... death. "These proteins are also some of the most broadly acting cellular oncogenes, and include cyclin E, c-Myc, Notch, and c-Jun," noted Dr. Clurman. "When Fbw7 is mutated in cancers, deregulation of these oncogenic Fbw7 targets is thought to contribute to cancer. SV40 T antigen contains a motif that mimi...

Research advances quest for HIV-1 vaccine

...es insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovere...nsortium (IAVI), which is focused on understanding broadly neutralizing antibodies at the molecular level and transferring this knowledge into the design of va...

Simple drug has the potential to save many lives threatened by malaria

...ith severe malaria. They found the two treatments broadly comparable and suggest that rectal artemether could be used to treat severe malaria where qualified staff and equipment for intravenous therapy is not available. These are encouraging results, say experts in an accompanying editorial. Although a sin...

Scientists identify new model Of NK cell development

... system is made up of lymphocytes, cells that fall broadly into three categories ?T cells, B cells and NK cells. Although all lymphocytes stem from a common source ?progenitor cells in the bone marrow ?they take different paths in developing into full-fighters in the immune system. For example, cells destin...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...to destroy. The Duke team discovered that certain broadly protective antibodies, which recognize and latch o...velope of the HIV virus into people or animals, no broadly neutralizing antibodies ?those antibodies that kill most HIV strains ?are made. This provides a plau...

NIH Calls on Scientists to Speed Public Release of Research Publications

... results of their work disseminated as quickly and broadly as possible, and NIH is committed to helping our scientists exercise this right. We urge publishers to work closely with authors in implementing this policy." "In developing this policy, we made a concerted effort to balance the importance of this a...

Alaskan puzzles, monitoring provide insight about North Pacific salmon runs

...y these runs see such different trends, by looking broadly at different systems subject to the same climate factors and constructing ecosystem conditions going back hundreds of years," Hilborn says. Hilborn is co-leader of the Alaska Salmon Program with Thomas P. Quinn and Daniel Schindler, faculty with the ...

Disease diagnosis, biodefense among UH chemical research projects

...nts novel DNA-sequence-based methods of sensitive, broadly applicable and false-positive resistant microbial identification. # George Fox, professor of biology and biochemistry and professor of chemical engineering, and Willson, with several other authors, will present research on "Neutral additive effects ...

Achilles heel of the herpes virus possibly found

..., HSV seems to have evolved to take advantage of a broadly present cellular protein that has properties like that of known cellular fusion machinery," says Fuller. "No other virus has been shown to use a cellular fusion protein for entry into cells." She explains that the search for the mechanisms by which ...

Researchers identify genes associated with lung transplant rejection

... in the lung, instead of anti-rejection drugs that broadly compromise the immune system, which are the major tools currently available to fight lung rejection. Co-authors of the study were Xiang Xu, MD, PhD, Jeffrey A. Golden, MD, Gregory Dolganov, PhD, Kirk D. Jones, MD, Samantha Donnelly, PhD, and Timothy...

Sickle cell disease corrected in human models using stem cell-based gene therapy

...e to correct sickle cell disease, but it should be broadly applicable to use therapeutically in stem cells or malignant cells." ...

Plants have a double line of defence

...hy, in nature, nonhost resistance is a durable and broadly effective defence mechanism. If a building block is missing from one defence layer, its function will be taken over by components of the next layer. Until now, scientists had assumed that nonhost resistance is based more on "passive" mechanisms: for...

Birth defects: 8 million annually worldwide

...percent if the recommendations in this report were broadly implemented," says Prof. Christianson. Among the interventions that would have immediate impact are folic acid supplementation to prevent neural tube defects; iodination of salt to prevent severe congenital hypothyroidism; and rubella immunization...

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

...esearch team to neutralize anthrax toxin should be broadly applicable in designing potent therapeutics for a variety of pathogens and toxins, including influenza and HIV," says Kane. The researchers tested their pattern-matching strategy by designing a polyvalent inhibitor for cholera toxin, demonstrating t...

New mechanism for essential genome-wide gene silencing identified

...ooks to be an evolutionarily ancient mechanism for broadly repressing and protecting the genome," says Shelley L. Berger, Ph.D., the Hilary Koprowski Professor at The Wistar Institute and senior author on the study. "We believe it to be the first identified mechanism of its kind." The new mechanism centers ...

Evolutionary shifts in olfactory sensitivities in fruit flies

...eral different levels of neural organization. More broadly speaking, the findings contribute to our understanding of the evolution of sensory systems and their adaptation to new conditions and resources. ...

Groovy protein essential for promoting cancer development

...mortalize cells ?and should help scientists design broadly effective cancer drugs. Until now, the lack of detailed structural information about the enzyme has hindered progress in developing agents to inhibit it, say the researchers, who published their findings in an advance online publication in Nature S...

Report lists top 20 most-vulnerable African carnivores

...mortalize cells ?and should help scientists design broadly effective cancer drugs. Until now, the lack of detailed structural information about the enzyme has hindered progress in developing agents to inhibit it, say the researchers, who published their findings in an advance online publication in Nature S...

Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic

... likely to adapt to human transmission, studies of broadly cross-reactive avian-influenza based vaccines with even modest immunogenicity in humans are important," said Macken, an influenza researcher in the Los Alamos Theoretical Division. Ideally, both vaccine strategies would be done in parallel: Stockpile...

New strategy developed to combat West Nile Virus

...f conditions were wet and the mosquitoes were more broadly dispersed, Shaman said. "This phenomenon, called 'drought-induced amplification,' is a key to transmission," he said. When summer rainfall increases, surface humidity levels rise and the mosquitoes are able to disperse and initiate secondary transm...

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