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Tag: "broad" at biology news

MSKCC researchers uncover structure of key protein complex in cells

...l for E3 activity," Dr. Lima said. "This model has broad implications for the function of E3s in all ubiquitin and ubiquitin-like conjugation." Dr. Nikola Pavletich, Chairman of the Structural Biology program at the Sloan-Kettering Institute, and an expert in ubiquitin, said the latest work "has given us ...

Digging in the dirt for life's biochemical foundations

...gi wring from the soil. Scientists have understood broad outlines of this evolutionary bargain for years, but specific details remained fuzzy, especially those related to nitrogen. To learn more about nutrient uptake, MSU researchers led by Shachar-Hill, along with collaborators at New Mexico State Univer...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...genic expression studies. Covalys already offers a broad range of kits for the subsequent labeling of SNAP-tag fusion proteins in live cells and in vitro with fluorescent or affinity probes. Kits to be introduced later this year by Covalys will allow for immobilization without prior purification, and purif...

NIH creates nationwide network of molecular libraries screening centers

...rs to explore novel ideas and enable progress on a broad front against human disease." For example, the broad-based screening effort will eventually enable researchers to explore the hundreds of thousands of proteins believed to be encoded by the approximately 25,000 genes in the human genome. To date, on...

New Scripps Oceanography project to study sediments and ecosystem restoration in Venice lagoon

....5 million project for Scripps, is part of Italy's broad commitment to safeguard Venice and its lagoon, the coastal wetland that surrounds the city and links directly with the Adriatic Sea through inlets. A team of scientists with SIOSED (Scripps Institution of Oceanography SEDiment research group) will d...

Bacteria are key to 'green' plastics, drugs

...ology at Rice. "One reason for this is succinate's broad utility -- it can be used to make everything from non-corrosive airport deicers and non-toxic solvents to plastics, drugs and food additives. Succinate's also a priority because some bacteria make it naturally, so we have a metabolic starting place f...

New Look at DNA Hints at Origin of UV Damage

...irulence factors may regulate innate immunity in a broad variety of hosts, including C. elegans, fleas and mammals. "The importance of our work is that it will permit us to use a model whose genetics can be easily manipulated as a viable alternative not only for the identification of novel Y. pestis virul...

Novel plague virulence factor identified

...irulence factors may regulate innate immunity in a broad variety of hosts, including C. elegans, fleas and mammals. "The importance of our work is that it will permit us to use a model whose genetics can be easily manipulated as a viable alternative not only for the identification of novel Y. pestis virul...

Bees, Brains and Addiction

...ge lecture by a local neuroscientist on a topic of broad public interest, televised broadcasts of that lecture locally and nationally by UCSD-TV and a corresponding educational Web site with information and lessons for students, teachers and anyone else interested in neuroscience topics. Among the particip...

When it comes to cell entry, being average has its advantages

...l experimental observations with cells, they found broad agreement. "The theory is fundamentally sound ?a significant outcome," Freund said. ...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

...xerts its functions in the brain by binding to two broad classes of receptors -- one class that transmits signals fast and another that acts through signaling pathways to relay messages more slowly. Dopamine receptors exist in two forms, D1 and D2 class receptors, both belonging to a class of slow-acting ...

Understanding how bacteria communicate may help scientists prevent disease

...um sensing could one day help scientists prevent a broad range of diseases caused by bacteria that are human pathogens. How do bacteria know how many are present? Each bacterium releases a small molecule, called an autoinducer. Each bacterium also has receptors ?proteins on its cell surface -- to sense au...

Making Sure Sacred Sheep Don't Become Extinct

... samples from at least 50 different males to get a broad sampling of genetic diversity. If there were ever a need to totally regenerate the Navajo-Churro breed from the ARS collection, a backcrossing strategy could be used. In such a situation, Churro semen would be used to inseminate a ewe from a differe...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...iple drug-resistant TB is no longer susceptible to broad categories of antibiotics, such as rifampicin, isoniazid, and streptomycin. Some strains of the common hospital infection-causing bacteria Staphylococcus aureus are resistant to all antibiotics except vancomycin, which is a drug of last resort, and s...

Innovative collaboration brings Arctic science into the classroom

... and July, Dr. Holmes, an ecosystem scientist with broad interests in the responses and feedbacks of ecosystems to environmental and global change, will travel from Woods Hole, Massachusetts, to Canada and Alaska as part the PARTNERS program (Pan-Arctic River Transport of Nutrients, Organic Matter and Susp...

Brain May Be Less Plastic Than Hoped

...onnectivity, be it subcortical, feedback, or other broad area-to-area connections. Of course, that is highly speculative. It is also conceivable—although in our opinion less likely—that in neocortical areas other than the primary visual cortex, new functional connections may have an easier time forming, an...

Putting ecology back into river restoration

...ent. According to Palmer: "It is critical that the broad restoration community, including funding agencies, practitioners and citizen restoration groups, adopt criteria for defining and assessing ecological success in restoration. Standards are needed because progress in the science and practice of river r...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...Both the guidance and a new Web page are part of a broad effort underway at FDA to foster pharmacogenomics during drug development. FDA also recently approved the first laboratory test, the Amplichip Cytochrome P450 Genotyping Test, which will enable physicians to use genetic information to select the rig...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

...ave such a short targeting sequence, they may have broad targeting ability, says Han. Significantly, the researchers found that for the AU-rich element degradation to work, the mRNA had to interact with multiple RNA binding proteins as well as microRNA. This suggests that the RNA binding proteins are ther...

Leprosy microbes lead scientists to immune discovery

...aching and training the 900-plus student body in a broad spectrum of disciplines crucial to the health and well being of individuals and populations around the world. Programs and projects range from the molecular biology of AIDS vaccines to the epidemiology of cancer; from risk analysis to violence preven...

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