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Tag: "breast" at biology news

COX-2 inhibitors significantly reduce risk of cancer

...prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar b...s have significant chemopreventive effects against breast cancer," says Dr. Randall Harris, professor and director of the Center for Molecular Epidemiology an...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...also have high levels of the enzyme COX-2 in their breast tissue were more likely to develop breast cancer than women with lower levels of the enzyme. According to Lynn Hartmann, M.D., professor of o...

AIDS-related cognitive impairment exists in two separate forms

...ound that it could also help predict recurrence in breast cancer patients. In this study, the researchers tested a total of six genetic markers - PITX2 plus five other methylated genes that were identified in tumor tissue taken from patients who recurred shortly after surgery. Hypermethylation of all six m...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...ound that it could also help predict recurrence in breast cancer patients. In this study, the researchers tested a total of six genetic markers - PITX2 plus five other methylated genes that were identified in tumor tissue taken from patients who recurred shortly after surgery. Hypermethylation of all six m...

Protein found to control tumor growth in certain breast cancers

...ntially new mechanism for controlling this type of breast cancer. Unraveling the intricate mechanisms of th...ed to tumorigenesis. Cells derived from the human breast cancer epithelial cell line MCF-7 ?the cellular model for estrogen sensitive breast cancer tumors ?w...

Molecular force field helps cancer cells defend against attack

...interaction with VEGFR-3 in cell cultures of human breast cancer. Breast cancers that pump out high volumes ... dividing and caused them to die but spared normal breast cells. "FAK is a critical molecule, and in the future different ways of targeting either the enzyme...

New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice

...to artificial light stimulated the growth of human breast tumors by suppressing the levels of a key hormone ...y female night shift workers have a higher rate of breast cancer. It also offers a promising new explanation for the epidemic rise in breast cancer incidence ...

Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

...ncer-fighting drugs are effective in killing human breast tumors. The unique properties of the hollow shell nano-particles, known as polymersomes, allow them to deliver two distinct drugs, paclitaxel, the leading cancer drug known by brand names such as Taxol, and doxorubicin directly to tumors implanted i...

Faults in newly discovered breast stem cells may lead to tumours

...he rare stem cell that drives the formation of all breast tissue. This discovery lays an important foundation for understanding how normal breast tissue develops. The identification of the breast stem cell is also likely to provide clues about ho...

Can dogs smell cancer?

In a society where lung and breast cancers are leading causes of cancer death worldwi...ish people with both early and late stage lung and breast cancers from healthy controls. The research, which was performed in California, was recently documen...

Creation of antibiotic in test tube holds promise for better antibiotics

... which when mutated is implicated in 25 percent of breast cancers. Preventing farnesylation possibly could prevent the cancerous effects, because the mutant protein would no longer be localized at the membrane, Nair said. An accompanying Perspectives article in Science, written by chemist David W. Christia...

Tumor cells that border normal tissue are told to leave

... This particular genetic change is common in human breast tumors. Boundary tumor cells were shown to lose surface proteins that attach them to other cells and stabilize their position within tissues. The study demonstrated that it was the difference in Src activity that led to the change in the attachment ...

New study reveals promising osteoporosis treatment

...increasing the risk of heart disease, strokes, and breast cancer. But the supplement Dr. LeGeros developed by combining magnesium (Mg), zinc (Zn), and fluoride (F) ions in a calcium-phosphate (CaP) matrix does not have the side effects of the current pharmaceutical-based treatments. Perhaps more important...

New test to detect rare proteins in blood

...undance molecules associated with cancers (such as breast cancer), Alzheimer's disease, prion diseases, and ...s found by other scientists to be overexpressed in breast cancer. Her2/neu is normally a low-abundance molecule that becomes overexpressed in more than 30 per...

Basic research leads to a novel cancer therapy

...on patients with advanced forms of bladder cancer, breast cancer, cervical cancer, colon cancer, esophageal ...netic alterations in the cells of certain forms of breast and ovarian cancer. It blocks the receptor Her2/neu in these cells, which thereby stop growing and b...

Single microRNA causes cancer in transgenic mouse

...ence indicated a poorer prognosis in patients with breast and lung cancers. Croce, along with Dr. Stefan Costinean , a research associate, decided to isolate miR155 function by inserting the gene, along with an enhancer, to promote its expression, into fertilized eggs inside a pregnant mouse. The research...

Breast implants not associated with cancer risk, study reports

Having breast implants is not associated with an increased risk ...ute. Implants were associated with a decrease in breast cancer risk and an increased lung cancer risk, but these results likely reflect the lifestyles and s...

On a fly's wing, scientists tally evolution's winners and losses

... disease genes such as BRCA1 (the first identified breast cancer gene); NF1 (neurofibromatosis); the gene associated with repairing DNA damage that might otherwise result in cancer (TP53); Smith-Magenis syndrome (SMS), and Charcot-Marie-Tooth type 1A10 (the most common type of inherited nerve disorder [CMT1...

Mouse to man: The story of chromosomes

... disease genes such as BRCA1 (the first identified breast cancer gene); NF1 (neurofibromatosis); the gene associated with repairing DNA damage that might otherwise result in cancer (TP53); Smith-Magenis syndrome (SMS), and Charcot-Marie-Tooth type 1A10 (the most common type of inherited nerve disorder [CMT1...

Study in Science holds promise for a new approach to drug therapy

...ilure, Cozaar for high blood pressure, Zoladex for breast cancer, Buspar for anxiety and Clozaril for schizophrenia, as well as by Zantac and Claritin. Together the drug class accounts for $200 billion in annual sales. Authors of the current study believe they have found a new way to regulate the same GCPR...

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