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Tag: "breast" at biology news

Promising cell protein may play role in infection and dry eye

...-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. In their study, the Penn and Temple researchers demonstrate for the first time an interaction between PAI-2 and...

Tumor wizardry wards off attacks from the immune system

...reg cells are much more prevalent in patients with breast cancer and pancreatic cancer than in healthy patients," says David C. Linehan, M.D., associate professor of surgery and a researcher with the Siteman Cancer Center. "The new findings show that tumors are directly responsible for the increase of T-reg...

Gene screen for breast cancer better than pathologist's 'eye'

...genetic blueprint is twice as accurate at spotting breast cancer cells as a pathologist's view with a micros...tists say they have tested their screening tool on breast fluid, in search of cells shed from growing tumors. "This screening method can see what the eye c...

Combination therapy with a monocloncal antibody and a vaccine leads to tumor rejection

...ssing GM-CSF (Gvax) was able to eradicate skin and breast cancer in mice. In a new study appearing online on June 15 in advance of print publication in the July issue of the Journal of Clinical Investigation, this same research group investigated the effects of CTLA4 blockade on the balance between Teff cel...

Recombination protein dynamics observed with single monomer resolution

... BRCA2, whose mutation increases susceptibility to breast and ovarian cancers. A better understanding of how these proteins function could help our understanding of cancer. "Our measurement technique provides a way of counting the number of individual monomers bound to DNA in real time," said Taekjip Ha, a...

Study identifies new role for breast cancer susceptibility gene

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechani... Cell, published by Cell Press. Mutations in the breast cancer susceptibility gene BRCA1 account for up to 50% of hereditary breast cancers. BRCA1 is known ...

New findings offer more complete view of breast cancer gene mutations in US population

... in two genes associated with an increased risk of breast cancer. The genes are called Breast Cancer 1 (BRCA...,000 women in the United States are diagnosed with breast cancer. The majority of breast cancer cases are caused by genetic changes that occur during a woman'...

Breast stem cells have features similar to 'basal' tumors

The most aggressive form of breast cancer may originate from breast stem cells that have undergone genetic mishaps. Victorian Breast Cancer Research Consortium scient...

'Signature' of chromosome instability predicts cancer outcomes

... and tumor metastases, and, in grade 1 and grade 2 breast cancer, distinguished the more aggressive cancers within each grade. ...

Cigarette smoke blocks cell repair mechanism, University of Florida study shows

Cigarette smoke can turn normal breast cells cancerous by blocking their ability to repai...s found only weak correlations between smoking and breast cancer risk, or none at all. Those findings are increasingly being challenged by newer studies that ...

Mass. General study finds potential ovarian cancer stem cells

...ls have been previously identified in leukemia and breast cancer and in cell lines of central nervous system and gastrointestinal tumors. Standard treatment for ovarian cancer ?surgical removal of all involved tissues followed by chemotherapy ?usually appears successful, but treatment-resistant tumors r...

New genetic test for breast cancer

...n be used to personalize treatment for early-stage breast cancer. "By using a molecular diagnostic test to assess whether a breast tumor will respond to chemotherapy, we're hoping to more precisely identify which patients can be ad...

Tamoxifen for breast cancer prevention does not benefit most women

Most women at high risk for breast cancer do not increase their life expectancy by ta...he lower end of the high-risk range for developing breast cancer, there is a very small likelihood that taking tamoxifen will reduce mortality," said Joy Meln...

Attacking cancer's sweet tooth is effective strategy against tumors

...hway's enzymes, LDHA, in a variety of fast-growing breast cancer cells, effectively shutting down glycolysis, and implanted the cells in mice. Control animals carrying tumor cells with an intact glycolytic pathway did not survive beyond 10 weeks. In striking contrast, only two of the LDHA-deficient mice die...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

... genes within the tumors of women with early stage breast cancer may allow identification of women who are a...ial marker of relapse in hormone-receptor positive breast cancer treated with tamoxifen," says Matthew Goetz, M.D., who co-led the project with James Ingle, M...

Cancer virus protein needed for successful infection

...s is spread by sexual activity, infected blood and breast milk. For this study, Lairmore and a group of collaborators developed a mutant strain of HTLV-1 that lacked p13. The researchers then infected one batch of rabbit T cells with the mutant virus and a second batch of rabbit T cells with a strain of n...

USC researchers investigate protein that protects tumors

A protein that allows breast cancer cells to evade the body's natural immune re...ceptin, one of the first biological treatments for breast cancer. Herceptin targets the her2 protein, which is found on the surface of tumor cells about 20 pe...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...an cancers, including cancers of the colon, ovary, breast and lung. Wave Basics Waves are circular ruffled surface structures on the exterior plasma membrane of a cell that can be observed through a conventional light microscope. They form in response to stimulation from EGF and exist for 10 to 20 minut...

Researchers identify genes in fruitflies that may shed light on human cancer spread

... those that arise from studies of human metastatic breast cancer cells than they do with studies of other tissues in the fruitfly, according to the study's senior author, Denise Montell, Ph.D., a professor in the Department of Biological Chemistry. The 353 genes identified in this study include some that a...

Researchers win money to develop breath test to detect breast cancer

One of the biggest problems in fighting breast cancer is the lack of inexpensive, early detection...th for the presence of metabolites associated with breast cancer. The team won a Breast Cancer Research Program Idea award, which funds promising, high-risk, ...

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