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Tag: "breast" at biology news

'Erectile dysfunction' drugs heighten natural anti-cancer activity

... Tests at Hopkins on mice with implanted colon and breast tumors showed that tumor size decreased two- and threefold in sildenafil-treated animals, compared to mice that did not get the drug. In mice engineered to lack an immune system, tumors were unaffected, proof of principle, the scientists say, that th...

Novel vaccine shows promise against early-stage breast cancer

A diagnosis of breast cancer has taken on a new meaning in the past 10 y...w harnessing what they have learned about treating breast cancer and applying it to possible methods of prevention to reduce the total incidence of the diseas...

Antibody extends life of mice with breast cancer

... metastasis, and, finally, in mice with metastatic breast cancer. "In addition to providing a survival advantage," said Rittenhouse-Olson, "JAA-F11 immunotherapy reduced the metastatic tumor burden significantly, reflected by both a dramatic decline in the overall incidence of spontaneous metastasis to ...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...LG100268 in particular could stop certain types of breast cancer in animal models. The compounds inhibited i...ors in a mouse model of estrogen receptor-negative breast cancer Triterpenoids and the rexinoid experimental drug LG100268 were also effective in combinati...

Mutant mouse provides insights into breast cancer

...n genetic defects in DNA replication (copying) and breast cancer. The mouse contains a mutation in a gene e...lawed copies of genetic material, leading to mouse breast cancers. In a paper published in Nature Genetics online (and upcoming in the Dec. 27 print issue),...

A fisheye view of the deadliest breast cancer

Inflammatory breast cancer (IBC) is the deadliest form of the disease,...find out what drives this most aggressive of human breast cancers, and to rapidly screen for drugs that might stop IBC, researchers at the University of Cali...

Abnormal overexpression of p53 is a predictive molecular biomarker

...mbined with chemotherapy to treat locally advanced breast cancer, and a 69 percent response when used with radiation to treat non-small cell lung cancer. ...

Quantum dots reviewed -- Could these nanoparticles hold the cure to cancer?

...e early success in the detection and treatment of breast cancer. The paper concludes with a quick look at what the future may hold for Quantum Dots in providing new insights into understanding the pathophysiology of cancer and real time imaging and screening of tumours. The level of details provided in...

Nano-devices hold promise for early-stage cancer detection

...ally. For example, the five-year survival rate of breast cancer patients when a tumor is detected at less than two centimeters in size is 98 per cent. It is only 26 per cent when the tumor is larger than five centimeters. For colorectal cancer, the second leading cause of cancer death, at least 90 per ce...

Researchers image molecular motor structural changes

...or example, the drug Taxol, which is used to treat breast and ovarian cancers, works by stabilizing microtubules. But the problem with using Taxol as a general inhibitor of cell division is that it works on all dividing cells, not just those involved in tumors or cancers, and so causes unwanted side effects...

Exposure to dioxins influences male reproductive system, study of Vietnam veterans concludes

...e exposed to the highest levels of dioxins through breast milk. Dioxins are eliminated extremely slowly from the body and they tend to stay in the body for several years to several decades after exposure. ...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

...Trichostatin A, currently under clinical study for breast cancer, restored skeletal muscle mass and prevented the impaired function characteristic of muscular dystrophies. Importantly, these restored muscles showed an increased resistance to contraction-coupled degeneration--the primary mechanism by which m...

World's smallest cancer detection device

...he tumor microenvironment of live animal models of breast cancer. By placing an artificial blood vessel near tumors, he was able to collect motile cancer cells for study and to predict--by the presence or absence of certain signaling molecules--whether the tumor cells have the potential to metastasize. Th...

Changing length of days reverses how estrogen affects aggressiveness in mice

...drugs is commonly used to treat estrogen-dependent breast cancer. In mice housed in short days (limited daylight as in winter), the drug halting estrogen production made the normally aggressive mice less aggressive. In mice kept in long day length conditions (as in summer), the normally docile mice were ...

Gene chip technology shows potential for identifying life-threatening blood infection

... technology is already used by doctors to diagnose breast cancer and predict a patient's response to various chemotherapy drugs, but this is the first time researchers have attempted to use gene chips to distinguish sepsis from non-infectious inflammation. Early symptoms of sepsis and non-infectious syst...

Temperament linked to onset of cancer and early death in female rats

...ley rat pups. The breed is prone to development of breast and pituitary tumors. In order to minimize the differences in temperament that are accountable to differences between rat families, the researchers compared behavior among sisters. The rats were tested at 20 days and 11 months of age in a cage to s...

New target for cancer therapy identified

...sor Liu and his colleagues have been investigating breast cancer cells to identify the molecular signalling that is required to turn on, and also inhibit, the gene that produces telomerase. They have found two proteins Smad3 and c-Myc that are involved in turning off telomerase production. Their finding...

Chemotherapy temporarily affects the structures of the human brain

... cognitive functions were significantly smaller in breast cancer patients who received chemotherapy than tho... measure volumes in specific areas of the brain of breast cancer patients who received chemotherapy and those who did not one-year after surgery and three-yea...

Restoring tamoxifen sensitivity in resistant breast cancer cells

The widely used breast cancer drug tamoxifen (Nolvadex®), which can becom...essfully since the 1970s to treat certain types of breast cancer and to prevent them from recurring after surgery. Clinicians observed that tamoxifen treatmen...

Other patients bear the real cost of Herceptin

...(NICE) recommends trastuzumab (Herceptin) in early breast cancer, but it provides no extra funding and does not suggest what cuts should be made to release this extra money. This leaves medical staff with difficult decisions to make. Doctors at the Norfolk and Norwich University Hospital NHS Trust and th...

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