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Tag: "bone" at biology news

Stem cells can repair torn tendons or ligaments

...mesenchymal stem cells (MSCs), which reside in the bone marrow and fat tissues, to express a protein called Smad8 and another called BMP2. When the researchers implanted these cells into torn Achilles tendons of rats they found that the cells not only survived the implantation process, but also were re...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

...covered cytokine to neural stem cells derived from bone marrow, researchers at Cedars-Sinai Medical Center... nervous system cells from stem cells derived from bone marrow. Because these stem cells originate in the bone marrow instead of the brain or fetal or embry...

Weighting cancer drugs to make them hit tumors harder

...ausing toxicity to vital organs such as the liver, bone marrow and heart. Likewise, chemotherapy's stay inside tumors is brief because it flows out as rapidly as it entered. In contrast, high molecular weight chemotherapy molecules are too large to be picked up by normal blood vessels. The drugs also rem...

Bone marrow cells can become functional gut lining cells

...esearchers report the discovery that cells used in bone marrow transplantation can develop into new cells ...tional Academy of Sciences. The study showed that bone marrow derived cells can differentiate into functional gastrointestinal epithelial cells after bone ...

Study fishes out new role for prostaglandins

...ddle layer (mesoderm), which develops into muscle, bone and cardiovascular organs, and the outer layer (ectoderm), which becomes the skin and nervous system. "The body is a tube in a tube in a shell," Solnica-Krezel explained. "Before gastrulation, all of these prospective tubes are at the surface of th...

Mutation in blood stem cells provides clues to cancer development

... cells. As a result of this intrinsic defect, the bone marrow produces excessive numbers of red blood cel...od. The disorder can also lead to scarring of the bone marrow and acute leukemia. Currently, patients are treated by bleeding them (phlebotomy) or adminis...

Secrets of the sea yield stronger artificial bone

The next generation of artificial bone may rely on a few secrets from the sea. Scientists...and colleagues have worked to fabricate artificial bone that is more bone than artificial, meaning it adapts to changing physiological conditions and meshes...

New weapon in battle against osteoporosis

...sly unknown regulatory mechanism in the process of bone loss. Their findings could open up new approaches ...at mice with a particular gene defect have a lower bone density. This breakthrough is making "cannabinoidreceptors" a key focus of osteoporosis research. "...

Newly discovered killer cell fights cancer

...ce. Then, the cell dies and is replenished by the bone marrow. "When an IKDC cell switches to its messenger function, the transformation is quite astonishing," says Pardoll. The cell sprouts long, hairy tentacles called dendrites. It uses its "arms" to increase the amount of surface area it reaches t...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

...g between donor and recipient that is needed for a bone marrow or conventional stem cell transplant, according to company executives. Another advantage is that use of immunosuppressive drugs does not appear to be required, in contrast to other types of stem cell treatment. Animals that received MultiSte...

Loosen leash on cancer protein 'watchdog,' researchers say

...ammal species typically show - thinner skin, lower bone density, spinal hunching and the like," Mendrysa said. "We couldn't find any differences between them and normal mice. And their cancer rates were dramatically lower than expected, which turned out to be the more significant finding of the study." M...

Bone and cartilage growth to blame for heart valve disease

...ol that stimulates certain cells to reprogram into bone cells in the aortic valve and cartilage cells in the mitral valve, says principal investigator Nalini Rajamannan, MD, newly appointed director of the Center for Heart Valve Disease in the Bluhm Cardiovascular Institute of Northwestern Memorial Hospit...

Retinol for combating leukemia cells

...are constantly dividing and they accumulate in the bone marrow impeding the formation of blood cells. In the analyses undertaken in the laboratory, it was seen that 95 % of these malign lymphoblasts died after application of retinamide. But what is the mechanism that really triggers this death? To explai...

New study reveals promising osteoporosis treatment

...en at low concentrations -- significantly improves bone strength and thickness without the side effects of...s and hormone therapies, do not effectively repair bone that has already been lost. In fact, bisphosphonates have been shown to actually inhibit bone redeve...

Measuring artery repair cells could become new heart disease test

...helial progenitor cells (EPC), are produced in the bone marrow and travel to the site of arterial damage. ...H is produced in high amounts by stem cells in the bone marrow as part of the process of maintaining the longer lifespans of these cells. Researchers have u...

How can we protect patients with weakened immune systems from influenza?

...ants for multiple myeloma (a cancer originating in bone marrow) and patients with ovarian cancer receiving an experimental treatment--an anti-cancer vaccine made from dendritic cells. Carl June, M.D., director of translational research at Penn's Abramson Cancer Center, leads both projects. A third group...

Bioactive cement scaffold may improve bone grafts

...hnology provides a method for making scaffolds for bone tissue. The scaffold is seeded with a patient's ow... a natural polymer (made from seaweed) filled with bone cells. The paste is shaped or injected into a bone cavity and then allowed to harden with the encaps...

Potential heart benefit found in stem cells

...enefit from mesenchymal stem cells (often found in bone marrow), but mostly because assist in the growth o...r stem cells to be used for cardiac therapy is the bone marrow. To improve global left ventricular ejection fraction (EF, the volume of blood pumped out of...

Findings advance use of adult stem cells for replacement bone

...covered a new way to culture adult stem cells from bone marrow such that the cells themselves produce a gr... of the science ?researchers found they could coax bone cells into produce up to 75 times more calcium ?but also because the study was conducted by an under...

Single microRNA causes cancer in transgenic mouse

...n humans, they are produced from stem cells in the bone marrow and then evolve through several stages before they become mature enough to create antibodies. Antibodies are proteins that sit on the surface of B cells or that are secreted by B cells that can detect the presence of foreign invaders like bact...

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