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Tag: "blocks" at biology news

Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors

...establishing itself in bone. By learning how DKK-1 blocks Wnt's signal to prostate cancer cells, they hope to learn how to control physical changes in bone that encourage the development of metastatic tumors. "Our goal is to find ways to manipulate this Wnt pathway to slow the growth of tumors in bone or d...

New insights into the software of life

... "Genes provide the code for making the building blocks of our bodies - the proteins ?and the consortium h...o contain the code to ensure that protein building blocks are made in the right place at the right time. "The new data provides several indications of the m...

Life in deadly conditions

...ls. But the greater portion of amino-acid building blocks in the proteomes of halophile archaea make it possible for the proteins to remain stabile, even in high salt concentrations. To survive among the extremely high pH-values, Natronomonas pharaonis also has a moderately increased pH-value inside its cel...

Building a better mouse model of lung cancer: FHIT counts

...er. "When VHL is in place and working properly, it blocks angiogenesis." Interestingly, humans whose VHL gene is lost or mutated suffer from a condition called Von-Hippel Lindau disease, an inherited disorder characterized by abnormal blood vessel growth in the eyes, brain, spinal cord, adrenal gland and o...

CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

...ng of the work is that for C. neoformans, high CO2 blocks sexual differentiation, which is known to be a key process for generating infectious spores, and the CA enzyme plays a central role in the process. Together with the accompanying work by Mühlschlegel and colleagues, this study implicates a key role f...

Mammalian Transcriptome Mapped

...e to take a gene from DNA to protein, the building blocks of our cells that in turn make up our bodies. RNA, which is a single strand of nucleotides, is made by enzymes as an exact base-to-base copy of DNA. Since DNA is double-stranded, only one of these strands, the so-called sense strand, encodes for pro...

Protein behind autumn color splendor identified

...ts until next year, when they are used as building blocks for new leaves. Other proteins, so-called proteases, have the task of degrading these proteins, and there is extensive research under way in this field. For example, the 2004 Nobel Prize went to three scientists who work with proteases. Proteases ar...

Anthrax stops body from fighting back, study shows

...a. Just two hours of exposure to the lethal toxin blocks the neutrophils' ability to produce these filaments by nearly 60 percent, paralyzing themand allowing the anthrax to move freely in the body, according to research released last week in The Journal of Infectious Diseases. The need to find new ways t...

U-M scientists say fused genes trigger the development of prostate cancer

...l Nature. The group's HapMap is a map of haplotype blocks and the tag SNPs that identify the haplotypes from a database of 160 million genotypes of 270 individuals from four different populations with ancestors from parts of Africa, Asia and Europe. The HapMap data is a major resource for understanding the ...

California computer scientists double volume of data in NIH biotech repository

...l Nature. The group's HapMap is a map of haplotype blocks and the tag SNPs that identify the haplotypes from a database of 160 million genotypes of 270 individuals from four different populations with ancestors from parts of Africa, Asia and Europe. The HapMap data is a major resource for understanding the ...

Fluoride poisoning in China due to clay, not coal

... clay with coal is much cheaper than burning large blocks of coal. The combined fuel is used to dry corn before storing it. Corn, however, absorbs more smoke than other grains, such as rice or wheat. Zheng's team found that only 15 per cent of the fluoride released when the coal and clay mixture is burnt c...

Scientists use gene transfer technology and common virus to block neuropathic pain

...rugs in adequate doses, because the same drug that blocks pain also interferes with brain activity, leaving people drowsy and unable to think clearly. "What we need is a way to release GABA in the spinal cord where it can selectively block incoming pain signals from peripheral nerves," says Fink. "If we ca...

Field tested: Grasslands won't help buffer climate change as carbon dioxide levels rise

... first three-dimensional structure of the building blocks of the carboxysome, a protein shell which is the best-studied microcompartment." The UCLA biochemists also report 199 related proteins that presumably do similar things in 50 other bacteria, Yeates said. "Our findings blur the distinction between e...

Nighttime Dying Linked To Sleep Apnea From Brain Cell Loss

... first three-dimensional structure of the building blocks of the carboxysome, a protein shell which is the best-studied microcompartment." The UCLA biochemists also report 199 related proteins that presumably do similar things in 50 other bacteria, Yeates said. "Our findings blur the distinction between e...

New discovery blurs distinction between human cells and those of bacteria

... first three-dimensional structure of the building blocks of the carboxysome, a protein shell which is the best-studied microcompartment." The UCLA biochemists also report 199 related proteins that presumably do similar things in 50 other bacteria, Yeates said. "Our findings blur the distinction between e...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...rugs in adequate doses, because the same drug that blocks pain also interferes with brain activity, leaving people drowsy and unable to think clearly. “What we need is a way to release GABA in the spinal cord where it can selectively block incoming pain signals from peripheral nerves,?says Fink. “If we can...

UCSD discovery may provide novel method to generate medically useful proteins

...oops varies in addition to the amino acid building blocks that constitute the antibody protein. Although this mechanism can generate more than 100 trillion different antibodies, the researchers say replicating it in a test tube would be very challenging because the loops would have the tendency to fold inc...

NYU chemists use computer simulation to enhance understanding of DNA transcription

... Specifically, chains of nucleosomes, the building blocks of chromatin that appear as bead-like structures along DNA, fold into a condensed fiber as salt increases. This folding and the interplay between chromatin structures regulate fundamental gene expression. However, the molecular mechanism underlying t...

Clearing jams in copy machinery

...bly line fashion, nucleotide bases -- the building blocks that make up DNA -- to convert the now-single-stranded templates into two new duplex DNA molecules. The new research shows that two different DNA polymerases, the high fidelity Pol III replicase and the low fidelity Pol IV, coordinate their action t...

Virginia Tech, Nanjing Institute researchers discover half-billion year-old fossils

...s of millimeter-sized tubes that were the building blocks of the Ediacara fossils from China. Their discovery thus directly confirms Seilacher's hypothesis. The new fossils also help to refine the Seilacher hypothesis. Seilacher originally hypothesized that Ediacara tubes had closed ends and were filled wi...

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