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Tag: "blocks" at biology news

Researchers reverse juvenile diabetes in animal model

...nal/pelvic area near the pancreas and lymph nodes, blocks the T cells as they travel to the pancreas to destroy beta cells. "We did this in mice, giving them six injections over the course of several weeks. The injections interrupted the T cell and beta cell interaction, allowing the beta cells in the pan...

Satellites show Amazon parks, indigenous reserves stop forest clearing

... region of Pará state. This connects two existing blocks of indigenous lands into a continuous corridor of protected tropical forest areas of 24 million hectares, the largest in the Amazon and the world. With broad alliances of support from indigenous groups, smallholder farmers, environmentalists, and g...

Researchers map of genetic variations implicated in disease

...0,000 years ago." Swapping of ancestral sequence blocks is a potential mechanism (identity-by-descent) whe... has been 'fixed'. We suggest that ancestral DR-DQ blocks have been shuffled into different MHC backgrounds and subsequently expanded in frequency across Euro...

Sweetgum tree could help lessen shortage of bird flu drug

...e, which is still in development. The drug, which blocks the replication of the flu virus, is being stockpiled worldwide to slow or stop a possible bird flu pandemic that some experts predict could kill millions ?if the virus mutates into a form that can spread from person to person. The virus, a strain kn...

Patterns in genome organization may partially explain how microbial cells work

...ome for the relative amount of four basic building blocks of DNA, the density of genes and expression level of those genes, and other factors. To detect patterns in those features, they used wavelet analysis, a statistical technique used to identify patterns in geophysical data such as significant warming ...

MicroRNA may have fail-safe role in limb development

...nslates DNA's message into proteins - the building blocks of cells, organs and all of the various systems of the body. Unnoticed next to the main ingredients, microRNAs were considered to be "junk" DNA, leftovers from millions of years of evolution. More recently, this genetic material is suspected to be p...

Researchers develop new method to help find deadly malaria parasite's Achilles heel

...nome is comprised of only two of the four building blocks of DNA. Stanly Fields, a professor of genomic sciences at the University of Washington who invented an ingenious way to identify pairs of proteins that physically interact with one another, modified his technique and added special culture conditions...

Scientists show how thinking can harm brain cells

...tter, the researchers said. Memantine, a drug that blocks glutamate receptors, is used in the treatment of Alzheimer's. Chemical preconditioning could represent an alternate or complementary strategy. "Preconditioning to protect the synapse is likely to be more important in the early and middle phases of n...

How the neuron sprouts its branches

...ibution points for proteins that form the building blocks of the growing dendrites. Besides Ehlers, who is at Duke University Medical Center, other co-authors were April Horton in Ehlers' laboratory; Richard Weinberg of the University of North Carolina at Chapel Hill.; Bence Rácz in Weinberg's laboratory; ...

The bioweapon is in the post

...-be bioterrorist could probably order the building blocks of a deadly biological weapon online, and receive them by post within weeks. That's the sobering reality uncovered by a New Scientist investigation into the bioterror risks posed by the booming business of gene synthesis. Dozens of biotech firms now...

Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain

...and glial cells -- the brain's structural building blocks -- that effectively blocks the delivery of most drugs from the bloodstream. But now scientists have found a new way to sneak d...

Students discover 11,000 year old remains of Irish Elk

...as found in a 'kettle hole' ?a hollow created when blocks of ice melt, now exposed in the eroding the cliff face. Its stratigraphic position, high up in the kettle hole, may provide a later date for the presence of giant deer on the island than previous studies. The antler, dubbed 'Erica the Elk' by the st...

Scientist uses form to explain function of key building blocks of life

...explains Markley. "Proteins are the basic building blocks of life, and are coded for by the genes in DNA. We'd like to be able to start with a gene sequence and predict the structure of a protein and its function. In this case, given an NMR pattern, we can tell you how the protein will act. In general, th...

Discovering the first steps in transcription-coupled repair

... transcription when ultraviolet-induced DNA damage blocks RNAPII. Transcription-coupled repair normally removes the blocking damage and allows transcription to recover; in Cockayne Syndrome, however, transcription cannot resume, and the affected cells die. "It has been assumed that defects in transcription...

Gene increases risk of tuberculosis

...iffering by only a single nucleotide (the building blocks of DNA). This change, which resulted in increased production of the MCP-1 protein, was five times more prevalent in individuals with active TB than in those who were infected but remained healthy. MCP-1 is a protein that helps attract immune cells ...

Synthetic Protein Eases Arthritis Symptoms in Mice

... his colleagues showed that in ALPS a form of PLAD blocks a cell surface receptor and prevents a needed chemical signaling pathway from functioning correctly. In ALPS, the signal pathway interrupted by PLAD leads to disease symptoms. But, the scientists reasoned, PLAD might also be able to block a related c...

Compound from marine bacteria shows potential as multiple myeloma therapy

...tients as well. In preclinical studies, NPI-0052 blocks a wider range of proteasome activities than bortezomib, say the researchers, and works at lower doses. NPI-0052 also appears to be less toxic to normal cells. Bortezomib is currently given by intravenous infusion. "NPI-0052 can be given orally, alt...

Grid bridges 4,800 miles for molecular repositories

...n more about some of the most fundamental building blocks of life. According to Doug Ray, chief research officer at PNNL, collaboration with researchers at these institutions, which rank among the world leaders in biological science, positions PNNL to contribute to breakthroughs in scientific understanding ...

DNA self-assembly used to mass-produce patterned nanostructures

...Bean said. "Plus, because we're using DNA building blocks that assemble themselves, we can simultaneously ma...wyer and their colleagues began with tiny building blocks they called "tiles." Each tile was made up of strands of DNA bent like pipe cleaners into the shape ...

Small molecule inhibitor of cholera discovered

...cesses essential for their survival, the new agent blocks production of bacterial proteins that cause the severe diarrhea associated with Vibrio cholerae infection. "What we have done is made a custom, organism-specific antibiotic against Vibrio cholerae," said John Mekalanos, the Adele Lehman professor o...

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