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Tag: "blocks" at biology news

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

...cts on the mice of another drug, dicyclomine, that blocks M1 receptors. They found that both normal and knockout mice treated with the drug showed the characteristic learning and memory impairments, as well as amyloid and tangle pathologies. The researchers also studied the effects of AF267B treatment on k...

Study finds 60 new genes controlled by DNA snippet

...mination was the CArG box. The nucleotide building blocks of DNA chains may contain any one of four nucleobases: adenine (A), thymine (T), guanine (G) and cytosine (C). Any sequence of code starting with 2 Cs, followed by any combination of 6 As or Ts, and ending in 2 Gs is a CArG box. According to Miano, ...

Newly discovered killer cell fights cancer

...ting mice with a cancer drug called Gleevec, which blocks an abnormal protein produced by cancer cells, and a growth factor for NK cells. The drug-growth factor combo served as a lure, leading the IKDCs to tumors implanted in the mice. The results were that tumors shrunk in mice, which received injections...

Manchester scientists create new bio-gel for 3D cell culture

...ons of modified dipeptides which act like building blocks and spontaneously assemble into nanometer sized fi...biological systems. "By using dipeptide building blocks instead of much larger oligo-peptides used by other researchers, we have greater control over the fi...

ASU researchers find link between social behavior, maternal traits in bees

...(characteristics of an organism) were the building blocks of social life, providing a foundation from which social forms could be assembled. For bees, our research supports the latter theory." Amdam's research began as a doctoral dissertation at the Norwegian University of Life Sciences. She continued the ...

Gene variation increases SIDS risk in African Americans

...xiletine, used to treat patients with arrhythmias, blocks late re-openings of sodium channels at low levels that do not interfere with normal function. Goldstein and colleagues found that the drug restored normal function in cells with two copies of the Y1103 channels even under acid conditions. Althoug...

Hopkins researchers discover genetic switch that turns off an oxygen-poor cell's combustion engine

...oduct of glycolysis. The disruption of this link blocks the tendency of the mitochondrion to make toxic mo...by glycolysis into acetyl CoA. Specifically, HIF-1 blocks the ability of PDH to make this conversion. HIF-1 does this by activating a protein called PDK, whic...

Macrophage signaling may affect hormone resistance in prostate tumors

...prostate gland, and anti-androgen treatment, which blocks the expression of androgen target genes, is widely used for the treatment of prostate cancer. Unfortunately, most patients eventually progress to an antagonist-resistant or hormone independent form of cancer, according to David W. Rose, Ph.D., associ...

UCSD team unmasks family of immune system invaders

... protective wall without any doors, a barrier that blocks bacterial entry from the intestine and colon into the rest of the body. However, bacterial pathogens can inject effector proteins into the intestinal epithelial cells, creating a door in the barrier. "As a result, these bacteria proteins are the ba...

Basic research leads to a novel cancer therapy

...ssels. When Flk-1/VEGFR2 is made inoperative, this blocks the development of tumours. If no blood vessels ar... a multi-targeted tyrosine kinase inhibitor, which blocks both the building of blood vessels in tumours as well as other illness-related enzymes in tumour cel...

Common enzyme is a key player in DNA repair

...f it," Walker explained. The molecular building blocks of DNA are adenine, cytosine, guanine, thymine ?A, C, G, and T in the shorthand of molecular biology. In different combinations, they make up the genes that code for the proteins that carry out the routine and complex tasks necessary for life. Now,...

Scientists discover basic defect in cystic fibrosis airway glands

...hick, sticky mucus that builds up in the lungs and blocks the airways. This makes it easy for bacteria to grow and leads to repeated serious lung infections. The thick, sticky mucus can also block tubes in the pancreas, preventing digestive enzymes from reaching the small intestine. The disorder results ...

A new focus for the mechanism of nerve growth

... that relaxes non-muscle myosin II and effectively blocks processes such as cell division. "Past research has focused on how actin structures are assembled at the leading edges of motile cells," said Forscher. "Instead, this paper investigates turnover or recycling of the actin networks. As the complement...

New cellular flaw found in some virulent breast cancers

...eing HER2-positive. The targeted therapy Herceptin blocks the mutation, improving the outlook for such patients, though it doesn't work in all cases. Sicinski said that a CDK4 inhibitor might be used in combination with Herceptin to provide further benefit in these patients. If a drug to block CDK4 proved ...

Utah researchers confirm chromosome may harbor autism gene

...cted family members is slight. When such identical blocks of SNPs are found, the chromosomal region often is a good candidate for being linked to a disease. Other studies, including the Finnish ones, have found a high degree of evidence linking chromosome 3 to autism, so Coon and the other U researchers b...

Clock molecule's sensitivity to lithium sheds light on bipolar disorder

...rn in a synchronized manner," says Lazar. Lithium blocks this action of GSK3, tagging Rev-erb for destruction, which leads to activation of clock genes such as bmal1. "We suggest that just as our cells in the incubator need to have their internal clocks reset, maybe this is what happens in some people with...

Anthrax inhibitor counteracts toxin, may lead to new therapeutics

...inds to a single site. "Think about how two Lego blocks snap together. A brick with four studs can interlock with a brick with four holes. These bricks will grip together better than if they had only one stud and one hole," says Jeremy Mogridge, Canada Research Chair and assistant professor of Laboratory ...

Next good dinosaur news likely to come from small packages

...niversities in the UK to track down these building blocks of bone. Ostrom works in a budding area known as paleoproteomics. Like conventional paleontologists, the search is to reveal the history of life on Earth. But tacking on proteomics means scrutinizing life at a molecular level ?life that existed tho...

How the brain learns to become addicted

...irectly into the VTA region of animals a drug that blocks orexin receptors, they found they could block the development of behavioral sensitization. "The findings presented here establish a potential mechanism for the role of orexin signaling in plasticity related to addiction," concluded the researchers. ...

New drug could reduce tissue damage after heart attack

..., inhibits all CRP functions in the test tube, and blocks the tissue damaging effect of CRP in an experimental heart attack model. Professor Mark Pepys, of the UCL Centre for Amyloidosis and Acute Phase Proteins, whose work on CRP has been supported by the Medical Research Council since 1979, says: "Altho...

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