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Tag: "blocking" at biology news

Gene therapy for Parkinson's disease moves forward in animals

...els of L-dopa were being produced in their brains, blocking side effects. ...

Scientists solve structure of key protein in innate immune response

...Since LPS is an important inducer of septic shock, blocking LPS receptors such as CD14 are among the most important targets. Our structure shows the shape of the LPS binding pocket of CD14. Now, drug developers will have better chance to design a molecule that will complement the shape of the pocket." ...

The Bacteria's guide to survival

...ein kinases, or MAPKs. The researchers showed that blocking MAPKs reduced the activity of several of the genes that are usually enhanced by infection with the normal bacteria. Also, they found that cells infected with the bacteria tended to survive treatment with staurosporine, a chemical that normally induce...

Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers

...on dioxide. It then closes its respiratory system, blocking off more intake of oxygen, to maintain the internal oxygen concentration at 4-5 kilopascals, the right oxygen concentration for its body. In a low-oxygen environment, the insect opens its respiratory system for longer periods of time; when it closes ...

Researchers add new tool to tumor-treatment arsenal

... lowers the amount of DNA-damaging agent needed by blocking p53's DNA-repair function, automatically killing the cancer cells when agents like cisplatin are introduced. "These findings provide the rationale for combining DNA-damaging agents with sensitizing agents like RAD001," says Dr. Thomas. "Since about ...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...els of L-dopa were being produced in their brains, blocking side effects. ...

Critical role in programmed cell death identified

... fragmentation, the cells survive; in other words, blocking fragmentation prevents cell death, inducing fragmentation provokes cell death. "This programmed cell death is so important and the more players we know that are involved, the more potential targets we have for therapeutics," Conradt said. During dev...

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

...nting the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain. "There is no magic bullet in fighting viral infections in neurons," said NYU Biology Professor Carol Shoshkes Reiss, the study's senior author. "However, these findings show the redund...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

... of heart rhythm problems through the mechanism of blocking a channel. Ultimately researchers from the University of Wisconsin led by Craig January, M.D., Ph.D., discovered that protease inhibitors do block these key channels. "Our findings suggest that as a class, protease inhibitors may predispose individu...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...evelopment of methods oftreatment for SLE based on blocking the function of the thyrosinkinaseenzyme," explains Lars Rönnblom.The other gene codes for a transcription factor, which also plays animportant role in regulating the interferon effect. Further functionalanalyses will be necessary to map the molecula...

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