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Tag: "blocking" at biology news

Depression gene may weaken mood-regulating circuit

... widely prescribed class of antidepressants act by blocking this protein, researchers have focused on possible functional consequences of a slight variation in its DNA sequence across individuals. Everyone inherits two copies of the gene, one from each parent, which comes in two common versions: short and lon...

Newest HIV drugs should be used with FUZEON(R)

... drug to work outside the human immune cell (CD4), blocking the HIV virus from entering. All other currently available HIV drugs fight the HIV virus once it has entered the cell. FUZEON's unique mode of action means that FUZEON has no cross-resistance with currently available drugs and that it is an effective...

Malaria mechanism revealed

... An important idea stemming from this view is that blocking the RII interaction--with drugs or vaccines--should block glycophorin A receptor binding and forestall malaria infection. To test this idea, the researchers created altered versions of the RII protein that they predicted would block the RII handshak...

Critical step traced in anthrax infection

...al to infection by mutating the region and thereby blocking translocation of the toxin proteins. These recent experimental results extend and explain a 1999 discovery by the Collier lab identifying a set of mutations in protective antigen that prevent translocation, some of which represented a new type of an...

Discovery could be key to bioterrorism defense

...ptor, we have a new target for activity, hopefully blocking the viruses from infecting cells," Dr. Broder explained. Team members Matthew Bonaparte, Ph.D., and Anthony Dimitrov, Ph.D., both at USU, identified the cell receptor by analyzing a human cell line that was resistant to virus infection against two su...

Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed

...the antero-posterior and left-right axes. However, blocking the retinoic acid pathway generated an uneven distribution of tissue on the right and left halves of the body. That is, somites (which give rise to the vertebrae and other body structures that are symmetrical) were unevenly distributed on the right a...

Gene silencing technique offers new strategy for treating, curing disease

...tly shut down gene expression in cultured cells by blocking the ability of chromosomal DNA to be copied into R... the messenger RNA once it's already produced. But blocking all the copies of messenger RNA before they can make a protein within a cell is akin to using a buck...

Tamoxifen-like drug suggests new ways to selectively block estrogen

...lating the effects of estrogen in some tissues and blocking it in others. The finding indicates that this little-known drug may play an important role in preventing, as well as treating, breast cancer and suggests ways to design new drugs with even more specific effects. In the May 13, 2005, issue of Molecul...

Beneficial Beetles Battle Pesky Saltcedar

...s, saltcedar bushes can trap natural flood debris, blocking waterflow and causing new, erosive channels to form. These channels sometimes undercut farm roads and fields, causing them to collapse. What's more, river rafters or thirsty wildlife and livestock often can't get through dense thickets of saltcedar ...

B cells are required for development of epithelial cancer associated with chronic inflammation

...cal interventions attenuating B cell activation or blocking B cell-mediated recruitment of innate immune cells may be effective in preventing premalignant progression." ### The researchers include Karin E. de Visser, Lidiya V. Korets, and Lisa M. Coussens of the University of California, San Francisco. K.E....

Rhesus monkeys can assess the visual perspective of others when competing for food

...nnot see them, but also that they know exactly how blocking or averting one's eyes can render one unable to see. Thus, even without any training, these monkeys were able to accurately consider the visual perspective of others when deciding from whom to steal. In previous studies, rhesus monkeys (and other pr...

Gladstone investigators discover how resting T cells avoid HIV infection

...y grows and wreaks havoc. They further showed that blocking production of the small, active form of A3G in resting CD4 T cells was sufficient to make these normally resistant resting cells highly susceptible to HIV infection. "Until now, the prevailing belief has been that HIV failed to infect resting T-cell...

Supercomputers to focus brains on AIDS dilemma

...hat proved to be highly effective against AIDS. By blocking the activity of the viral enzyme HIV protease, these protease inhibitors brought greatly extended life-spans to patients who previously faced early deaths. Structural biology and molecular dynamics computer simulations played an important role in the...

Migratory songbirds have a specialized night-vision brain area

...he birds' eyes covered. The researchers found that blocking night-time vision dramatically reduced gene activity in cluster N. "This result confirmed that night-migratory birds seem to have a brain area specifically adapted for seeing during their night-time flight," Jarvis said. The researchers suspect that...

Scientists discover that three overlapping signals in embryo help get the backbone right

...repeated attempts, however, no one could show that blocking signals like noggin did the opposite. In fact, blocking noggin and the other known factors seemed to have relatively little effect on the embryo, raising do...

New understanding of DNA repair may pave way to cancer treatments

...de that interferes with ATF2 function, efficiently blocking melanoma growth in mouse models. Ongoing studies are devoted to screening for compounds that mimic the peptide's actions and to allow for further development of the peptide toward clinical assessment. "Until our recent studies, we were certain that ...

Researchers identify protein crucial for survival of Lyme-disease bacterium

...lf, then in theory you could disrupt that cycle by blocking whatever that mechanism is," Dr. Norgard said. Traditionally, scientists studying pathogens have looked at genes that affect how the infecting organisms behave once inside a human host. What tends to get ignored, Dr. Norgard said, is the other side ...

NYU study reveals how brain's immune system fights viral encephalitis

...nting the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain. "There is no magic bullet in fighting viral infections in neurons," said NYU Biology Professor Carol Shoshkes Reiss, the study's senior author. "However, these findings show the redund...

Towards precise classification of cancers based on robust gene functional expression profiles

...ent, he says. A potential drug treatment based on blocking the MIF protein is already being explored. In a study presented last year at an ACS national meeting, the researchers reported they were able to prevent diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. ...

Chemists identify key gene in development of type 1 diabetes

...ent, he says. A potential drug treatment based on blocking the MIF protein is already being explored. In a study presented last year at an ACS national meeting, the researchers reported they were able to prevent diabetes in a group of mice by using a synthetic compound called ISO-1 to block the MIF protein. ...

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