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Tag: "blocking" at biology news

Mechanism for Epstein-Barr virus protein's role in blood cancers discovered

...toms. Now, the researchers are in the process of blocking the molecular signals caused by EBNA3C's presence in B cells. This points the way to a possible drug for EBV-related cancers. "Stopping this step in the life cycle of EBV could be a major potential target for the development of therapeutics for treat...

Stem cells' electric abilities might help their safe clinical use

...ealthy cells for transplantation. "We found that blocking potassium channels in ESCs also slowed their growth," says Li. "Our findings may lead to genetic strategies that suppress undesirable cell division after transplantation, not only for ESCs and their derivatives, but perhaps for adult stem cells as w...

Gene therapy reverses genetic mutation responsible for heart failure in muscular dystrophy

...d vessel capillaries act much like a mosquito net, blocking the gene drugs from reaching the muscle cells. Fortunately, we found a virus that is just small and sneaky enough to get through this net and deliver the therapeutic gene to both skeletal and cardiac muscle cells," said lead author, Xiao Xiao, Ph.D.,...

Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease

...Their tests in cell cultures and mice suggest that blocking the pathway by interfering with a blood cell growth gene, known as FLT3, targets an immune system cell often ignored in favor of T-cell targets in standard therapies. FLT3, which controls the development of healthy blood cells, was identified as a ...

Researcher at UGA College of Veterinary Medicine identifies new way of combating viral diseases

...veterinary college, and his colleagues report that blocking a protein that helps transport viruses out of a ce...eir condition with diet and medication.Temporarily blocking the Rab9 pathway would be unlikely to harm the body, Hodge added, because human cells tend to have b...

Researchers discover new tumor defense system

...fatty acids act against cytotoxic T lymphocytes by blocking a number of the lymphocytes' signaling events. For example, they keep certain proteins from being phosphorylated and they also prevent an increase in intracellular calcium that is essential for the cytotoxic T lymphocytes to kill the tumor cells. Dr....

Cells direct membrane traffic by channel width

...he most narrow, but there are other tight barriers blocking the way as well, said Emad Tajkhorshid, assistant director of research in the Beckman lab. "Membrane proteins are difficult to crystallize," he said. "We don't have the known structure of many of them. There has been a lot of recent progress, and fo...

Researchers find molecule that inhibits regrowth of spinal nerve cells

...ctivity as well or better than that of other known blocking agents combined, UT Southwestern researchers report in an upcoming issue of the Proceedings of the National Academy of Sciences. "I believe that to the extent that overcoming myelin-based inhibition is going to provide some sort of functional recove...

Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy

...t receptors from leaving the cell surface, thereby blocking the initial step that occurs during heart failure. Also, the researchers reported, when they eliminated tropomyosin activity altogether, they also maintained heart receptors. "These studies demonstrate a previously unknown role for the protein phosp...

Sugar helps control cell division

...d which enzymes take it off -- and knocking out or blocking these enzymes allowed the researchers to control whether proteins were sugar-laden or sugar-free. "Normally, the enzyme that adds the sugar to proteins is enriched at the hub of activity during cell division," notes Slawson. "When we knock it out or...

IBM Transforms the Art of Scientific Expeditions

...ally enhance radiation's cancer-killing effects by blocking a "master switch" in cancer cells that promotes ca...15, 2005, issue of Cancer Cell. "We've shown that blocking HIF-1 at the wrong time therapeutically in a cancer cell yields no benefit and can actually impede o...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...ally enhance radiation's cancer-killing effects by blocking a "master switch" in cancer cells that promotes ca...15, 2005, issue of Cancer Cell. "We've shown that blocking HIF-1 at the wrong time therapeutically in a cancer cell yields no benefit and can actually impede o...

Discovery of T-cell 'traffic control' boosts new drug promise

...reats the autoimmune disease multiple sclerosis by blocking excess S1P action. The research also shows the pro...ush of T cells to the transplantation site without blocking normal immune response against bacteria and other infectious agents," he says. Similarly, such a dru...

Treatments have same target, different responses for lung cancer patients with genetic mutation

... such as gefitinib and erlotinib (Tarceva) work by blocking signals in the intracellular domain of EGFR--betwe... the cell, as opposed to the intra-cellular signal blocking of drugs like gefitinib. The researchers treated seven different NSCLC cell lines with cetuximab ...

New lead reported in tumor angiogenesis

...ding suggests a future anti-angiogenic strategy of blocking not only the secreted molecules but also the cell-to-cell contact. Wang said these early data also suggest the intriguing possibility of directing growth-inhibiting drugs at the normal blood vessel cells to stop angiogenesis. "It's well established ...

Nicotine triggers the same brain reward circuitry as opiates

... are critical for determining the effectiveness of blocking nicotine reward . . . . Given the results reported here, clinical studies designed to evaluate administration of opioid antagonists just prior to cues associated with smoking could lead to a more promising treatment regimen." ...

New type of rejection blocker protects kidneys after transplant

...ving the value of a new type of treatment based on blocking the immune system's reaction to a transplanted org... required before the T-cells attack the kidney. By blocking this second signal, belatacept prevents destruction of the kidney without suppressing the immune sys...

Study shows how retinoic acid enters a cell's nucleus

...move to the nucleus and promote cancer, perhaps by blocking the hormone that switches on its NLS. In previous experiments with mice, Noy and her colleagues showed that by increasing CRABP-II levels within cells, tumor growth rates slow dramatically. The protein transfers RA rapidly and efficiently to the cel...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...uel the growth of tumors, researchers believe that blocking angiogenesis may choke off a tumor's blood supply and kill the cancerous cell. Varner and her team found that a specific integrin protein called alpha4beta1 was produced at high levels in one part of a developing blood vessel, the interior area call...

Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief

...arijuana-like compound called 2-AG, and it is that blocking compound, patented by UC-Irvine, that could become...rijuana-like compounds as having a crucial role in blocking pain, but no one understood the conditions in which these compounds were released to block pain. Re...

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