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Tag: "blocking" at biology news

New understanding of parasite cell structures may provide treatments for serious tropical diseases

...gin looking for compounds that may act as drugs by blocking the parasite's ability to respond to extracellular stress." ...

Taking the wrinkles out of motoneuronal disease

...cies has resulted in deadly neurotoxins capable of blocking neuronal communication. I am using our knowledge of the mode of action of these neurotoxins to design a selective motoneuron delivery system that could change our way of treating motoneuronal diseases." Dr Meunier's innovative research caught the at...

Researchers attack tumor cells by exploiting dependency on sugar metabolism

...rd Medical School, and colleagues examined whether blocking the conversion of glucose to lactate in mammary tumor cells might help shed light on the association between tumor survival and the interplay between glycolytic phenotype and mitochondrial metabolism. The researchers used a sophisticated genetic tech...

Researcher studies, treats military with 'silent disease'

...tion in which scar tissue replaces healthy tissue, blocking the flow of blood through the organ and preventing it from working as it should. Cirrhosis is the twelfth leading cause of death by disease, killing about 26,000 people each year, according to The National Digestive Diseases Information Clearinghouse...

Meth promotes spread of virus in HIV-infected users

...gulation of the meth-specific dopamine receptor by blocking it, we may be able to prevent the interaction of meth with its specific receptors, thereby inhibiting the virus attachment receptor," said Nair. "Right now, we don't know how the virus-attachment receptor and meth-specific receptors interact wi...

Research links protein to breast-cancer migration

...ead to new approaches to treating breast cancer as blocking the protein's actions has the potential to stop cancerous cells migrating. "What we have identified is a new role for a protein called LPP," explained Professor Andrew Sharrocks, who headed the research team. "Until now, this protein was only thoug...

Tumor wizardry wards off attacks from the immune system

...ility. Such information could lead to a method for blocking tumors from using T-reg cells for protection. Other research by Linehan and colleagues showed that in mice with pancreatic cancer, simply depleting T-reg cells slowed tumor growth and increased survival time. "We're looking at several potential ways...

Failure of 'scout cells' may lead to cancer in transplant patients

...rence for higher IFNg levels. They also found that blocking TGFb prevented the EBV-related cancer. We hypothesize that the balance between IFNgƒnand TGFb is probably important in determining whether or not the cancer develops, VanBuskirk says. In the new study, for example, adding IFNg to TGFb prevented...

Cells use mix-and-match approach to tailor regulation of genes

...ation should give scientists who are interested in blocking transcription factors a powerful new tool to narrow their search to the most promising candidates." ...

Scientists discover why cornea is transparent and free of blood vessels, allowing vision

...ng up all the C and D VEGF growth factors, thereby blocking them from binding with VEGFR-2. And, because this binding took place in a non-vascular setting, the growth factors were neutralized. To test their theory, the team conducted a series of experiments. Using corneal tissue from mice, the team did th...

A new tool against brain disease

...that they could reinvigorate the killer T cells by blocking that inhibitory switch, which is called programmed...cells' inhibitory PD-1 pathway. He also found that blocking the PD-1 pathway in the mice restored T cell function and reduced the amount of virus in the animals...

How HIV 'exhausts' killer T cells

...that they could reinvigorate the killer T cells by blocking that inhibitory switch, which is called programmed...cells' inhibitory PD-1 pathway. He also found that blocking the PD-1 pathway in the mice restored T cell function and reduced the amount of virus in the animals...

Bubbles go high-tech to fight tumors

... to tumors, or to deliver drugs. The process of blocking blood flow to a tumor is called embolization, and using gas bubbles is a new technique in embolotherapy. What makes it so promising is that the technique allows doctors to control exactly where the bubbles are formed, so blockage of blood flow to sur...

Rehydrate -- your RNA needs it

... particular proteins involved in certain diseases, blocking key steps in the disease process. "It's likely that water helps mediate the binding between these aptamers and their disease-causing protein targets, ultimately keeping the protein away from where it can wreak havoc," Walter said. "So the fundamen...

Protein clue to tailor-made antibiotics

... are now trying to establish what it is about this blocking mechanism (which they've christened 'competitive recruitment') that lowers the cells' defences toward the colicin. ...

Cigarette smoke blocks cell repair mechanism, University of Florida study shows

...te smoke can turn normal breast cells cancerous by blocking their ability to repair themselves, eventually triggering tumor development, University of Florida scientists report. While some cells nonetheless rally and are able to fix their damaged DNA, many others become unable to access their own cellular f...

Mechanism identified for promising neurological drug

...an tell, the only way it blocks inflammation is by blocking PARP-1." Swanson says the results have implicatio...rug is working." One is potentially negative. "In blocking PARP-1, you block DNA repair," he cautions. "That will likely be true of minocycline. And in blockin...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...troyslation reaction, altering PDI's structure and blocking its normal neuroprotective function, which ultimately leads to nerve cell injury and even death. These new results also show that this altered form of PDI is present in elevated amounts in patients with Alzheimer's and Parkinson's Disease, indicatin...

Pigeons provide clue to solving common problem in heart patients

...y uses a balloon-like device to crush the material blocking an artery. But, within three to six months, even if a stent is placed in the artery to keep it open, the vessel becomes re-blocked in about 25 percent to 30 percent of patients. This process, known as restenosis, has been described as "over exuberant...

New potential drug target in tuberculosis

...ake over LipB's role. This means that an inhibitor blocking its active site would shut down key processes the bacterium needs to survive and replicate. This would be a very effective strategy for a drug." The scientists will now search for compounds that can do so. At the same time, they are continuing to lo...

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