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Tag: "blocking" at biology news

A new target for painkillers

...Vc1.1 can treat nerve hypersensitivity and pain by blocking a molecule in cells known as the "alpha9alpha10 nicotinic acetylcholine receptor." "The numerous analgesic compounds currently available are largely ineffective" for chronic nerve pain, McIntosh and colleagues write. "Our findings not only suggest...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...a number of ways: halting nitric oxide production, blocking cyclooxygenase and nitric oxide expression, curbing proliferation and inducing apoptosis in human lung cancer cells. They tested CDDO-MA and LG100268 on mice for 20 weeks. CDDO-MA and 268 reduced the number of lung tumors to 9.1 in the group fed C...

Scientists discover role for dueling RNAs

...cause they continually produce IME4 antisense RNA, blocking the production of sense RNA. Antisense IME4, then, safeguards against meiosis in cells that can't handle it. "This is the first time that we've found a function for antisense RNA, that is not RNAi, in a higher cell type," says Hongay. "In fact, ...

Friendly bacteria in alcoholic milkshake could fight food allergies

.... "Friendly" bacteria in kefir may play a role in blocking the pathway involved in allergic responses, Lisa Richards reports in Chemistry & Industry, SCI's fortnightly magazine. Research published today [Monday 16 October 2006(DOI 10.1002/jsfa2469)] in the SCI's Journal of the Science of Food and Agricul...

Newly discovered behavior in cancer cells signals dangerous metastasis

... progression of tumors could lead to therapies for blocking metastasis, he said. ...

UCSD researchers discover internal compass of immune cell

... were blocked, the cells became disoriented, while blocking A3 adenosine receptors slowed down the cell movement toward chemoattractants. The researchers also found that drugs which interfere with the amplification system impair cell migration to inflamed tissues. "These findings are very important becaus...

UCSD researchers create roadmap to integrin activation

...elets stick inappropriately, clumping together and blocking the blood vessel. A signal from inside the platel... clots, by binding to the receptors and completely blocking their function. However, long-term administration of similar drugs doesn't work, in part because of...

Pair of microRNA molecules controls major oncogene in most common leukemia

...ger RNA or can inhibit translation of the genes by blocking production of proteins from messenger RNA, according to Pekarsky. Earlier this year the investigators provided the first direct evidence that over-expression of an miRNA molecule could result in development of cancer have since identified a number ...

Gene therapy research switches off joint inflammation; switches on genetic process of joint repair

... human cartilage and restores joint function while blocking joint destruction associated with inflammation. The IRA is the preeminent meeting for inflammation investigators. Mark J.S. Miller, Ph.D., M.B.A., Professor of Cardiovascular Sciences and Pediatrics at Albany Medical College (NY) and head of the Rep...

New biochip helps study living cells, may speed drug development

... some of the most potent venoms and toxins work by blocking these channels, including the venom of certain snakes and strychnine. Porterfield's chip is technically classified as a "cell electrophysiology lab-on-a-chip." The device is further described in an article in the journal Sensors and Actuators, pu...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...ing to estrogen receptors in place of estrogen and blocking the signals that lead to cell division. Initially, tumor growth slows or stops altogether. With continued tamoxifen treatment, however, the estrogen receptor and the estrogen-dependent signaling pathways in the cell can become altered, rendering tamo...

Jefferson researchers uncover new way nature turns genes on and off

...ferent: ncRNAs instead can repress Ubx activity by blocking its activity in certain types of cells in the developing embryo. "Importantly, non-coding RNAs are very tightly developmentally regulated, as we show in case of bxd RNAs," Dr. Mazo notes. "These create an enormous potential to regulate the neighbo...

A new jump start for aging blood vessels

... proper regulation of blood pressure. Second, blocking TNFa via chronic etanercept treatment decreased cell death in aged vessels, demonstrating that increased TNFa levels likely contribute to age-related cardiovascular disease. Similar cell-protective effects were found when anti-TNFa antibodies were us...

Cell wall of pneumonia bacteria can cause brain and heart damage

...e cells. Furthermore, the researchers succeeded in blocking a key enzyme of this pathway in cardiomyoctyes using a molecule called PLC inhibitor U73122. The treatment prevented the cell from taking up the fragments but did not appear to interfere with the cell's normal functions. This suggests that a drug tha...

New angiogenesis finding may help fight cancer growth

...ogenesis only during pregnancy and to heal wounds, blocking angiogenesis could be a promising way to halt tumo...vating the NK-B receptor blocked angiogenesis, and blocking the receptor stimulated angiogenesis," Bresnick says. In theory, selectively stimulating angiogenesi...

New treatment for severe malaria

...ood cells, which then accumulate in large amounts, blocking the flow of blood in the capillaries of the brain and other organs. The reason that the blood cells conglomerate and lodge in the blood vessels is that once in the blood cell the parasite produces proteins that project from the surface of the cell ...

Light-sensitive photoswitches could restore sight to those with macular degeneration

...l. Green light unkinks it and replugs the channel, blocking ion flow. Isacoff said that this same photoswitch could be attached to a variety of proteins to push or pull them into various shapes, even making a protein bend in half like a tweezer. In 2006, in a cover article in the new journal Nature Chemic...

Interfering RNA silences genes in 'slippery' immune cells

...s broader access to RNA interference, a process of blocking the activity of targeted genes. RNA interference has recently emerged as an important tool in studying how genes function in normal biological processes and in disease. Writing in the Journal of Immunological Methods, published online on March 24, a...

Just like us, social stress prompts hamsters to overeat, gain weight

... can block stress-induced obesity, for example, by blocking the release of the stress hormone, corticotrophin releasing factor (CRF), or by blocking the body's CRF receptors, Bartness said. CRF, also sometimes referred to as corticotrophin releasing...

Trials for new drug to overcome HIV

...king HIV on new front. Many existing drugs work by blocking reverse transcriptase, an enzyme that enables HIV to replicate within cell. Others disable protease, which helps to assemble the virus into particles that infect other cells. Recent experiments in collaboration with Michael Sakalian and his colleagu...

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