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Tag: "blocking" at biology news

Cells re-energize to come back from the brink of death

...APDH appears to save cells from CICD suggests that blocking this enzyme would kill abnormal cells that lack caspase activation and cannot undergo apoptosis. That strategy would be the basis of novel anti-cancer drugs. The St. Jude study was conducted in culture dishes in which normal cells were exposed to ...

Brain inflammation may be friend, not foe, for Alzheimer's patients

...ly about half “This work provides evidence that blocking all inflammatory responses in Alzheimer’s disease is not an ideal therapy,” added Shaftel. “This might hinder processes that are beneficial and part of the body’s adaptive response to fight plaques.” The new findings hinge on a very special mouse ...

Pesticides choke pathway for nature to produce nitrogen for crops

...as fertilizer by the plants. "Agrichemicals are blocking the host plant's phytochemical recruitment signal," said the study's lead author, Jennifer E. Fox, a postdoctoral researcher in the Center for Ecology and Evolutionary Biology at the University of Oregon. "In essence, the agrichemicals are cutting th...

In mice, drug protects against diabetes and atherosclerosis

... normal diet, the scientists said, suggesting that blocking aP2 may not be harmful in people -- though this remains to be determined. The report describes tests of the inhibitor on cell systems in culture and in live mice. In one experiment, mice genetically engineered to be highly susceptible to atheroscl...

Migration alert -- How tumor cells home in on the lymphatic system

...t a drug target for lymph node metastases could be blocking the signaling molecule or its receptor on the tumor cell.”...

Herpes virus hijacks DNA repair process

...irus, has a similar protein. Scientists found that blocking murine herpes virus from activating the DNA damage...met. "We don't want to treat viral infection by blocking DNA damage response systemically because this process is used constantly throughout the body and is ...

Alien plants attack using 'resource conservation' as weapon, researchers say

...ing sugar into the soil to lock up nutrients or by blocking sunlight with tarps. But these experiments had relatively limited success. "Our results can maybe explain why that method didn't work for all the invasive species," Funk said. Current techniques for fighting invasive species typically involve earl...

Molecule that destroys bone also protects it, new research shows

...iously, using rats and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and possibly for other autoimmune diseases such as multiple sclerosis, colitis, psoriasis and lupus. The effects of an IL-17 deficiency in periodontal disease, however, were unknown, so ...

WHO data confirms low level of resistance to Tamiflu

...clinically relevant influenza viruses and works by blocking the action of the neuraminidase (NA) enzyme on the surface of the virus. When neuraminidase is inhibited, the virus is not able to spread to and infect other cells in the body. It is licensed for the treatment and prophylaxis of influenza in child...

DNA repair proteins monitored at double-strand break

... to make cancer cells more sensitive to therapy by blocking their ability to repair double-stranded breaks caused by chemotherapy or radiation. It could also suggest new strategies for enhancing repair of double-stranded DNA caused by radiation, natural oxidants in food or the body and other toxins that can c...

LIAI scientists make important finding on cytomegalovirus transmission

...dulate immunity in vivo with the desired result of blocking virus spread to uninfected individuals. "The po...ormally attack the cytomegalovirus," he said. "By blocking the ability of the IL-10 molecule to bind to its receptor, then you allow these T cells to do their ...

First demonstration of new hair follicle generation in an animal model

...n regenerate instead of just repair. Conversely by blocking wnt proteins, they also found that they could stop the production of hair follicles in healed skin. Increased wnt signaling doubled the number of new hair follicles. This suggests that the embryonic window created by the wound-healing process can ...

Newly identified mechanism for silencing genes points to possible anti-cancer strategies

...prevent the assembly of a competent ribosome, thus blocking messenger RNA translation at that gene. The result would be to silence that specific gene. We tested this idea in human cells and in worms and found it to be the case in both. Interestingly, this not only supported our hypothesis, but to see it in su...

New compound prevents alcoholic behavior, relapse in animals by blocking stress response

...uild on previous work showing the effectiveness of blocking certain CRF receptors—proteins that bind CRF and make it active—in treating alcohol dependence in animals. CRF levels in the brain rise in the short term after drinking; in subjects that are not dependent, this activation returns to normal within a d...

Discovery could lead to better control of hemorrhagic fever viruses

...cells, and show that infection can be inhibited by blocking this receptor. The findings, to be published online by the journal Nature on February 7, give a clue to the high lethality of New World arenaviruses, suggest a way of reducing the severity of infection, and point the way toward a sorely needed treatm...

Bacterial walls come tumbling down

... Penicillin and many newer antibiotics work by blocking a piece of the machinery bacteria use to construct their durable outer walls. Without these tough, protective coatings, bacteria die. The enzymatic machinery (known as PBP2) studied by Strynadka's group has two main parts: One end assembles long suga...

3 proteins may play important role in nerve-cell repair

...wth of the nerve extensions. The study showed that blocking GPR3 greatly slows the growth of the nerve extensions. The researchers reversed this effect by restoring either GPR3 or GPR12 in the cells. High levels of the three proteins were also linked to higher levels of cAMP, with GPR6 and GPR12 increasin...

Antifungal drug kills TB bug

...d azoles are able to kill off fungal infections by blocking the actions of one of its P450s that is essential for maintaining the cell structure," said Professor Munro. "We were able to show in laboratory experiments that various types of these azole drugs were also very good at killing the TB bacterium, and ...

UW launches study testing adult stem cells for heart damage repair

...o the heart and send small blood clots downstream, blocking the small blood vessels in the heart. These blockages can result in a series of mini-heart attacks that, while they may be too small to notice at the time, in aggregate cause significant long-term damage to the heart muscle and disability to the p...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

...gar cloak prevents antibodies from slipping in and blocking the proteins the virus uses to latch onto a cell and infect it. In 1998, Dr. Kwong and colleagues published the first X-ray snapshot of the core of HIV gp120 as it attaches to a cellular receptor known as CD4. That image gave researchers a glim...

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