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Tag: "biomarker" at biology news

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...ty to breast cancer and may be a valuable in vitro biomarker to identify high-risk subjects, especially in familial breast cancer families," the authors write. "It is unclear at this time whether there are any interventions that could alter DNA repair capacity and what effect such interventions might have on r...

Improved Outcomes Releases GeneLinker(TM) Gold and Platinum Version 4.6

...ocused primarily on importing and analyzingprotein biomarker data, a high priority for many of our customers. F...mmitment toserving user needs--analysis of protein biomarker data, identifyingchannels that statistically distinguish between different classes andnew import for...

Nanoscale Diagnostic Sets Sights on Alzheimer's

... BCA process, unique microparticles latch onto the biomarker targets ?in this study, the ADDLs. The particles a...-DNA particles and magnetic particles sandwich the biomarker targets. A magnet separates the sandwich complexes from the rest of the sample. The complexes are t...

Product improves peptide identification for proteomics research

...s applications, such as protein identification and biomarker discovery, potentially leading to a better understanding of diseases like cancer and speeding drug development efforts. The Agilent 1100 Series LC/MSD Trap XCT Ultra offers significantly improved scan cycle times, enabling collection of mass spectra ...

Secret of smallpox's success may lead to bioterror cure

... call a 'pathogen associated molecular pattern' ?a biomarker that is only present in your body when you are infected with a virus and that the body knows to look for and respond to," said Jacobs. "The body responds in a lot of different ways, but the main way is it starts producing an immune response ?double-s...

UCLA cancer researchers shake loose hidden biomarker

...boratory Medicine found a way to move an important biomarker expressed in prostate cancer, shaking it loose fro...," he said. Rajasekaran said PSMA is an important biomarker for prostate cancer and its expression in the cell is proportional to the severity of the cancer ?th...

Study casts doubt on 'Snowball Earth' theory

...eposits from southeastern Brazil and applied lipid biomarker techniques to identify prehistoric organisms based on the fatty remains of their cell membranes. The team, which included scientists from USC, Caltech, the University of Maryland and a Brazilian mining company, identified "a complex and productive m...

Researchers identify genes associated with lung transplant rejection

...rger, separate set of patients to prove that these biomarker genes actually work. And we're testing that now." Currently, Caughey's research team is studying biopsy samples from more than 100 UCSF lung transplant patients, who regularly undergo biopsies as part of standard follow-up care. Another potential be...

Scientists closer to new cancer detection method

...ould be an indication of the existence of a cancer biomarker in the body. In that event, the person could seek a more thorough examination." ...

Evolutionary biology research techniques predict cancer

...wn cancer. If so, genetic diversity might act as a biomarker for cancer risk among patients with precancerous t...d grow. In the future, in addition to serving as a biomarker for cancer risk, he adds, measures of genetic diversity might help doctors assess the success of can...

Researchers create pigs that produce heart-healthy omega-3 fatty acids

...wn cancer. If so, genetic diversity might act as a biomarker for cancer risk among patients with precancerous t...d grow. In the future, in addition to serving as a biomarker for cancer risk, he adds, measures of genetic diversity might help doctors assess the success of can...

Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury

...valuation, and any leftover was frozen so that the biomarker concentrations could later be measured. The infants were then tracked until 1 year of age to determine whether any were subsequently diagnosed as being abused. Researchers were then able to determine how well the biomarkers established which children...

Aging cells, aging body: Fresh evidence for a connection

...ng. For replicative senescence, the most important biomarker is telomere dysfunction-induced foci, or TIFs. Presence of these structures signals that the protective chromosome caps called telomeres have dwindled enough to halt cell division. Scientists painstakingly counted the cells with aging biomarkers. Wh...

'Smart' genetic therapy helps the body to heal itself

... SMN2 levels in their blood. With the help of a biomarker we hope we will be able to distinguish between patients who will respond to this drug and which will not." The results show that valproate is able to exert a direct effect on the activity of the human SMN gene, says Professor Wirth, but it is still ...

Major cancer study aims to identify protein markers for early-stage disease

...ducting mass spectrometry in the context of cancer biomarker discovery. Mass spectrometry is a technique used to detect and measure the precise molecular weight of proteins. A critical second step will involve consolidating the data and analyzing it, with the goal of piecing together the fragments of proteins ...

Inflammation markers identify fatigue in breast cancer survivors

... of two immune response elements," he added. "This biomarker identifies ?and can predict ?which women have long...f these patients." Dr. Irwin defined the fatigue biomarker in collaboration with Alicia Collado-Hidalgo, Julienne E. Bower, Patricia A. Ganz, and Steve W. Cole...

Antioxidant protects against lung damage in silicosis

...from lung lesions, it could also represent a novel biomarker for evaluating the severity of silicosis. In their mouse studies, hemin, a potent inducer of HO-1, suppressed acute inflammation after silica exposure, whereas zinc protoporphyrin, an inhibitor of HO-1, accelerated the development of silicosis les...

Abnormal overexpression of p53 is a predictive molecular biomarker

...erapy - making it potentially the first predictive biomarker test for a gene-based drug. Researchers at Introgen Therapeutics, Inc., in Austin, Texas, found that patients with advanced squamous cell carcinoma of the head and neck cancer (SCCHN) whose pre-treatment tumor samples over-expressed p53 protein were...

Newly identified biomarker detects and regulates spread of brain tumors

...s Winship Cancer Institute have identified a novel biomarker for brain tumors and have uncovered a potential ro...rocytoma should be explored further as a potential biomarker for monitoring the growth of these tumors or as a potential new target for therapy." ...

Studies find general mechanism of cellular aging

...owever, the gene may prove immediately useful as a biomarker for studies of aging, Sharpless said. "If you were...ngs were having a beneficial effect? Now we have a biomarker that can directly test the effects of such things," he said....

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