Building a human kinase gene repository
...nardo Brizuela (Harvard Medical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequence information of all identified human kinase genes and have built a gene repository for this gene class. Their work is described in the online early edition of Proceed...Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
...rug. "These findings provide new insights into the biological basis of de novo multiple-drug resistance and illuminate potential new targets for overcoming this cause of treatment failure in childhood ALL," explains Dr. Evans. ...To sea or not to sea: When it comes to salmon sex, size sometimes doesn't matter
The ones that stay and the ones that stray are biological puzzles among Pacific salmon, of whom the vast majority ?but not all ?travel thousands of miles to sea and back to the streams where they hatched. There are chinook salmon populations in Idaho in which an occasional male stays put and matures when o...UCLA scientists store materials in cells natural vaults
...ir lifespans AUTHORS: Leonard Rome, professor of biological chemistry and senior associate dean of research; Bruce Dunn, professor of material science and engineering; Jeffrey Zink, professor of chemistry and biochemistry and Valerie Kickhoefer, first author and associate research biochemist. JOURNAL: The Pr...Signs of aging: Scientists evaluate genes associated with longevity
...dulthood would be those most critical to the vital biological process of aging. In addition, they reasoned that some of the genes that were differentially expressed between daf-2 mutants and controls would also be associated with longevity. Most strikingly, the scientists observed that during the early and mid...Findings have implications for tracking disease, drugs at the molecular level
...ack a single molecule of a drug in a cell or other biological sample." Other advantages of the technique are th...icity, and can readily be attached to molecules of biological interest, said Fourkas. In addition, the laser light used to visualize the particles is at a wavelen...Researchers make surprise discovery that some neurons can transmit three signals at once
...research could eventually provide insight into the biological cause of these disorders and help to identify novel approaches for prevention and treatment. Further study could have particular implications for dyslexia and tinnitus ?often referred to as ringing in the ears ?which can be caused by abnormal inhibit...Changing ecosystems throw scientists mega-challenges
...preading of diseases, and the increasing threat of biological and chemical terrorism. Among the research challenges are the need to understand how and why these changes are occurring—especially when multiple stresses are acting on environmental systems simultaneously—and how best to respond to them. "Now more ...Finding hidden invaders in a Hawaiian rain forest
...ethods are exciting because they detect effects of biological invasions on ecosystems, not just the presence of an invader. Islands like Hawaii are vulnerable to biological invasion; new species can wreak havoc very quickly. The fact that the new techniques allowed the sci...Scripps scientists find potential for catastrophic shifts in Pacific ecosystems
...nderlying dynamics responsible for major shifts in biological and physical conditions of the North Pacific Ocean...s discovered that the data for the North Pacific's biological systems exhibited shift-like fluctuations consistent with "nonlinear" mechanisms. Measuring regimes ...wFleaBase: the Daphnia genome database
...within freshwater ecosystems and over 200 years of biological investigations. By consequence, the Daphnia Genomics Consortium (DGC) has launched an interdisciplinary research program to create the resources needed to study genes that affect ecological and evolutionary success in natural environments. Descriptio...Discovery clarifies role of peptide in biological clock
...y mice in hopes of unraveling more clues about our biological clock. VIP is not "very important person," but va..., has discovered that VIP is needed by the brain's biological clock to coordinate daily rhythms in behavior and physiology. Neurons in the biological clock, an ar...Breakthrough isolating embryo-quality stem cells from blood
...ll ?its stretchiness or elasticity ?instead of its biological make-up, to decide whether or not it's a stem cell. Stem cells don't need a rigid "cytoskeleton" to hold them in shape, which makes them stretchier than normal cells. Käs and Guck's machine uses a powerful beam of infrared laser light to stretch and...Stealth Worms May Improve Insect Pest Control
...tand how diverse they are, but also to use them as biological control alternatives," says Patricia Stock, a nema...they interact with the local insects. Using native biological control alternatives is more environmentally friendly than importing other pest control agents." Kn...Software Tool for Converting Scientific Text into a Database of Functional Relationships
... Processing-based tool for automated extraction of biological facts from scientific literature, MEDLINE abstract...ern matching algorithms specifically developed for biological text analysis. It extracts functional relationships between proteins, cell processes, and small mole......rt of the genome that codes for the most important biological functions -- the virus had an even stronger effect. What researchers don't understand is why the virus affected the ancestors of chimps, gorillas, and Old World monkeys, but didn't affect the ancestors of humans or of Asian apes like orangutans and ......-server software for visualization and analysis of biological pathways and gene regulation networks for bio-medi...ern matching algorithms specifically developed for biological text analysis. “PathwayStudio?Central helps scientists to keep current with literature using embedd...Microscopes at microscopic size
...e optical biochips onto which scientists can place biological samples. Special fluorescent chemicals are then us... probe technology and also to make the analysis of biological samples more sophisticated. Professor Paul Smith, the research group leader, said, "Our research an...A new way to share models of biological systems
...BioModels, the world's first database of annotated biological models. BioModels is the result of a collaboration...up that develops open-source standards to describe biological systems. Other contributors include the Keck Graduate Institute (USA), the Systems Biology Institute...Hydrogen and methane provide raw energy for life at 'Lost City'
... "Lost City shows us that geological, chemical and biological processes are intimately linked at a primal environment, and lends strong support to the need for interdisciplinary approaches to scientific research." Other co-authors are Gretchen Früh-Green, Swiss Federal Institute of Technology; Dana Yoerger, Jo...