Nanoscale Diagnostic Sets Sights on Alzheimer's
... have the capability to effectively interface with biological molecules." ?Sohi Rastegar, a bioengineering expert and the NSF program director who oversees the agency's support of the Northwestern NSEC and several other bioengineering centers. "This will be a biosensing system with high sensitivity and specifi...Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
...ystems biology and is crucial to understanding the biological relevance of genome-wide changes in mRNA and prote...otein data bank/PDB. Folded proteins explain many biological functions -- just as the parts in a car determine the role they play in the car's function, three di...Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
...te of cholesterol production. "In addition to the biological significance, the findings have important clinical implications for cholesterol control," he said. Cholesterol-lowering statins--taken by an estimated 10 million people each day to protect against coronary artery disease and reduce the incidence of ...50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel
...y of Chicago have found that a recently discovered biological process known as sumoylation -- until now thought to be active only in the nucleus -- also occurs near the cell's surface where it regulates at least one and possibly many kinds of proteins, providing a novel target for the development of new drugs. ...Stopping smallpox in its tracks: A new anti-viral approach
...ritical at a time when the threat of smallpox as a biological weapon is high. ...Scientists discover how plants disarm the toxic effects of excessive sunlight
... highly reactive and toxic substance that destroys biological molecules. "We've discovered a pathway that cells use to turn on certain genes and respond to singlet oxygen," says Timothy Donohue, a professor of bacteriology in the university's College of Agricultural and Life Sciences and lead researcher on the...Key mechanism in genetic inheritance during cell division identified
...hed to microtubules, hollow fibers in the walls of biological cells that are responsible for the faithful segreg...together to form a highly flexible cytoskeleton in biological cells that gives shape to cell walls and other structures, and controls the transportation of substa...Multi-purpose protein regulates new protein synthesis and immune cell development
...thway," says Randal Kaufman, Ph.D., a professor of biological chemistry in the U-M Medical School and an HHMI in...zhong Zhang, Ph.D., a senior research associate in biological chemistry and first author of the paper. "All these things disrupt protein folding and put stress on...Gene therapy promising for growing tooth-supporting bone
...ool of Dentistry. Francesci also is a professor of biological chemistry. R. Bruce Rutherford, a former U-M Dentistry professor who now serves as chief scientific officer of private tissue engineering firm Ivoclar Vivadent-Dentigenix, was a co-author, as well. ...Computational Method Speeds Mapping of Cell Signaling Networks
...undation postdoctoral research fellowship award in biological informatics. Several organizations supported the work, including the National Institutes of Health, Bristol-Meyer Squibb and the Juvenile Diabetes Foundation. ...GeneNotes - A novel information management software for biologists
Analyzing microarray data - or even a simple biological network - can get you lost - quick. Tons of genes,...n, integration and interpretation of heterogeneous biological information still heavily rely on the sensibility of biologists. Biologists often feel overwhelmed b...Glow-in-the-dark zebrafish at UH hold keys to biological clocks
...earchers have found new tools that shed light upon biological clock cycles. Gregory M. Cahill, associate profes...s a better chance of identifying mutant fish whose biological clocks run fast or slow, providing the ability to trace the specific genes that create the anomaly. ...Researchers rein in regulatory RNAs
...of poly(A)-negative nuclear RNA may have important biological functions." Among these functions may be the regulation of gene expression on a domain level, such as that which has been documented for several imprinted loci. Antisense transcripts have been shown to alter the methylation status of the overlapping...Microbial forensics: The next great forensic challenge
...exist; and the availability of basic knowledge and biological equipment in hospitals, universities, industries, ... link to suspects," Murch said. Additionally, the biological and ecological complexity of most biothreat agents present forensic microbiologists with a number of...Buying Time Through Hibernation on Demand
...uman or a human organ into an oxygen-free state of biological limbo and then reversing the process at will with no ill effects may sound like science fiction, dozens of documented cases exist of humans surviving prolonged hibernation-like states with no lingering physical or neurological damage. For example: *...U-M team recovers ancient whale in Egyptian desert
...uman or a human organ into an oxygen-free state of biological limbo and then reversing the process at will with no ill effects may sound like science fiction, dozens of documented cases exist of humans surviving prolonged hibernation-like states with no lingering physical or neurological damage. For example: *...Navigating an integrated yeast network
...ts have for the first time mapped multiple complex biological interactions in a yeast cell in a simple graphical...actions between macromolecules that can be tied to biological phenomena and may help represent more fundamental network design principles than do simple motifs. ...Researchers uncover sequence of major rice pathogen
..." Bringing the genome to life means capturing the biological meaning of the genome, Dean says. To do this, he and his colleagues used two strategies: comparative genomics and functional genomics. "In comparative genomics, you compare this genome to that of other organisms, other fungi," Dean says. "But fungi ...Reservoirs may accelerate the spread of invasive aquatic species, researchers say
...n survey evidence indicating that the physical and biological properties of reservoirs make them more likely to be invaded by exotic species than natural lakes. The researchers point to cases in which reservoirs are believed to have facilitated the rapid spread of invasive species. The authors note that reserv...Disease diagnosis, biodefense among UH chemical research projects
...hydrate-protein interactions that are important in biological systems. # Roman S. Czernuszewicz, associate professor of chemistry, will present research on "Resonance Raman spectroscopy of nitrophorins." Nitrophorins are a family of heme proteins found in certain insects that store nitric oxide (NO). Having im...