Growing nerve cells in 3-D dramatically affects gene expression
...s in your body," said Diane Hoffman-Kim, the Brown bioengineer who spearheaded the new study, "so culture method is critical. If you want to better understand how the human body behaves or how new drugs might fight disease, 3-D may be a better bet." For more than 100 years, scientists have grown human cells i...Bones in motion: Brown scientists to create new 3-D X-ray system
... a diverse team of Brown researchers. They include bioengineer Joseph Crisco, computer scientist David Laidlaw, orthopedic experts Braden Fleming and Douglas Moore, and biologists Stephen Gatesy, Thomas Roberts and Sharon Swartz. Brainerd, a professor of medical science in Brown's Department of Ecology and Evolu...Lab-on-a-chip could speed up treatment of drug-resistant pneumonia
...; Exhibition in San Francisco, Michael Lochhead, a bioengineer at the Denver biotechnology company Accelr8, described a new lab-on-a-chip that can identify single bacterial cells for the most common cases of drug-resistant pneumonia, cutting down the wait from days to hours. The technology could also help in the...Better sludge through metagenomics
...ormation now available, there are opportunities to bioengineer the process to make it more reliable." Removing excess phosphorus from wastewater can be most economically accomplished by environmentally friendly biological means in a process known as enhanced biological phosphorus removal (EBPR). The researche...One therapeutic dose of radiation causes 30 percent spongy bone loss in mice
...rtical bone, suffered the damage," said Bateman, a bioengineer who studies bone biomechanics. The remaining spongy bone must redistribute the load to bear the weight, but this makes the bone support structure less efficient and leaves the bone more vulnerable to fracture. "A murine model for bone loss from the...When the going gets tough, slime molds start synthesizing
...he way to exploit this novel domain arrangement to bioengineer more efficient ways of making modified polyketides for human uses," said Austin. Moving to the bench, Austin and Noel lab manager Marianne Bowman isolated Dictyostelium DNA encoding the type III PKS domains and not only determined their structure,...Nano-particles effective in killing cancer with one-two punch of chemotherapeutics
...ions". Discher developed polymersomes with Penn bioengineer Daniel Hammer in the 1990s. The Discher lab is further studying the drug- and gene-delivery capabilities of polymersomes, tailoring their shapes, sizes, loading and degradability to each application. Discher theorizes that polymersomes could be mad...Both alcoholism and chronic smoking can damage the brain's prefrontal cortex
... and graceful as an intact, biological limb," says bioengineer Greg Clark, the University of Utah's principal investigator on the project. "That's what our researchers, teaming with others around the world, are setting out to achieve. ?People's arms and hands are not only tools, but also an important means by wh...... and graceful as an intact, biological limb," says bioengineer Greg Clark, the University of Utah's principal investigator on the project. "That's what our researchers, teaming with others around the world, are setting out to achieve. ?People's arms and hands are not only tools, but also an important means by wh......technological point ofview," suggests Drew Endy, a bioengineer at the Massachusetts Institute of Technology. A more realistic risk is that terrorists could order genes thatfconfer virulence to dangerous pathogens such as the Ebola virus, and engineer them into another virus or bacterium. They could also order g...