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Tag: "biochemical" at biology news

RNA interference stops colon cancer spread in mice

...roteins -- including specific proteins involved in biochemical reactions that promote cancer and other diseases. ...electively block components of the PI3K pathway, a biochemical pathway that is activated in a number of cancers, and suppress the spread of colon cancer in experim...

African parasite makes component of fat differently from all other organisms

...issue of Cell, "show that this is a completely new biochemical pathway for making fatty acids," says Soo Hee Lee,...other fatty acids, and now we found that it uses a biochemical pathway we never knew to look for." They learned about this new fatty acid-making pathway by hunti...

Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety

...scheid's group reports how NPS also can reduce the biochemical and behavioral symptoms of schizophrenia in an established animal model for this mental illness that affects some 2 million Americans. Animals pretreated with NPS before receiving a drug that normally induces psychotic-like behaviors did not develop...

Neuronal cell cultures kept on the straight and narrow

...art of a multidisciplinary NIST program to develop biochemical measurement technologies based on microfluidics. ...

Purdue creates new low-cost system to detect bacteria

...like conventional methods, we don't have to do any biochemical staining, DNA analysis or other types of manipulation," said Bartek Rajwa, a staff scientist at the Bindley Bioscience Center in Purdue's Discovery Park, the university's hub for interdisciplinary research. Particles of light, called photons, bounc...

Technique speeds up detecting, treating wound bacteria

... procedure--culturing and identifying organisms by biochemical activity, etc.--can take one to several days and sometimes weeks, depending on the organism," he said. His technique is also useful in detecting flora that can't easily be grown in culture because no one's been able to determine just what the bacte...

Major obesity gene is 'lost in the shuffle'

... slender body shape and size, although there is no biochemical or physiological evidence to suggest this. "In essence, we are observing the result of an ancient gene 'knockout' experiment," Ishida explains. "The deletion ?or 'knockout' ?of the ASIP gene may have helped gibbons adapt to arboreal niches. We...

Researchers find molecular 'brake' to cell death

... ATP. However, through a series of biological and biochemical experiments, Tang and his research team found that adding ATP to a cancer cell could potentially impede apoptosis. They discovered that these nucleotide pools, in fact, act not to promote apoptosis through production of ATP, but to hinder it. They ar...

Oxidation defense in mosquitoes benefits malaria parasite

...nte Orientale). The synthesis of XA is one of the biochemical defenses against oxidative stress resulting from 3...can damage cells," said Li. Mammals have various biochemical pathways of disposing of 3-HK, which mosquitoes lack. Research by Li's group at Virginia Tech on Aed...

Mystery solved: Gold's power against autoimmune diseases defined

...for drug development. "But instead we discovered a biochemical mechanism that may help explain how an old drug works." DeDecker and co-author Stephen De Wall, PhD, undertook a large-scale search for new drugs that would suppress the function of an important component of the immune system, MHC class II proteins,...

Thinner and younger

... their DNA, thought to be a marker of aging at the biochemical and cellular level. "This study has laid the groundwork for future research into the long-term effects of calorie restriction in humans to see whether it really can extend lifespan," Holloszy says. "It's becoming clear from studies with the CRONies ...

How nice, brown rice: Study shows rice bran lowers blood pressure in rats

...ctivity to the picture, along with a host of other biochemical markers that track blood glucose (implicated in diabetes), lipid profile, kidney function and the harmful effects of free radicals. For example, high levels of a marker called 8-OHdG indicate biological stress and genetic damage due to oxygen-based ...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...ion to fight and defeat the intruder. But when the biochemical processes of the immune system are either misdirected or chronically turned on, inflammation can lead to adversity, including some forms of cancer. For this reason, scientists are closely studying the link between inflammatory processes and tumor fo...

Stable polymer nanotubes may have a biotech future

...ade from other materials are used for transport in biochemical applications, but are typically fragile and usually collapse within a few hours. The NIST team developed processes for extending the shelf life of polymer nanotubes--considered essential for commercial applications--and forming sturdy nanotube networ...

Gene thwarts some pathogens, gives access to others, could save crops

...ive the early signals needed to set off a relay of biochemical events allowing the plant to fight off the pathogen, Mengiste said. "Basically the BIK1 protein does this by regulating a plant defense hormone called salicylic acid," he said. "The amount of salicylic acid determines the type and level of a plant's...

Report lists top 20 most-vulnerable African carnivores

...ion within the complete enzyme. It took a few more biochemical tricks, but eventually Jacobs crystallized the protein fragment and analyzed it using x-ray diffraction. Finally, the researchers were able to obtain an extremely detailed three-dimensional map, elucidating the position of each individual atom with...

Groovy protein essential for promoting cancer development

...ion within the complete enzyme. It took a few more biochemical tricks, but eventually Jacobs crystallized the protein fragment and analyzed it using x-ray diffraction. Finally, the researchers were able to obtain an extremely detailed three-dimensional map, elucidating the position of each individual atom with...

Hopkins researchers discover genetic switch that turns off an oxygen-poor cell's combustion engine

...he HIF-1 gene cuts the link between two ATP-making biochemical pathways: glycolysis, which makes modest amounts of ATP by breaking down the glucose without using oxygen; and the TCA cycle in the mitochondrion, which normally uses oxygen to produce large amounts of ATP by processing a byproduct of glycolysis. T...

'Shuttling' protein possibly key to resilience of cancer cells

...mice called F9, which, when subjected to the right biochemical signals, have the ability to alter their properties and are considered to be "cancer stem cells." The hypothetical cancer-resistance role of cancer stem cells could explain why tumors return after treatment. If stem cells prove to be critical to canc...

Nobelist discovers antidepressant protein in mouse brain

...ferent ways, but in all cases they caused the same biochemical change. So, it's pretty convincing that p11 is associated with the main therapeutic action of antidepressant drugs." Since humans and mice with symptoms of depression were found to have substantially lower levels of p11 in brain cells compared to...

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