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Tag: "binding" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...urned up the function of sterol responsive element binding proteins. These important parts of the mechanism activate many key genes of lipid biosynthesis involving the pathways of cholesterol and triglycerides; these genes directed the liver to manufacture more cholesterol, which it does in the form of very ...

A new mechanism of regulating RNA degradation

...d onto Staufen1 (Stau1). Stau1 is a well-known RNA binding protein and some of its functions in the common fruit fly Drosophila are understood. "But no one knew what Staufen1 did in human cells," said Maquat, even though its presence in mammalian cells has been recognized for several years. "We were surpris...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...d onto Staufen1 (Stau1). Stau1 is a well-known RNA binding protein and some of its functions in the common fruit fly Drosophila are understood. "But no one knew what Staufen1 did in human cells," said Maquat, even though its presence in mammalian cells has been recognized for several years. "We were surpris...

Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants

... bio-conjugates to uncover new knowledge about the binding of a protein at the growingpollen tube tip. This protein plays a critical role along with anotherprotein (chemocyanin) in guiding sperm-laden pollen tubes to the eggsfound in ovules. Applyingnanoparticles for imaging the protein localization reveale...

New binding target for oncogenic viral protein

... and Welcker suspect that by acting as a decoy and binding to Fbw7, T antigen protects cellular Fbw7 targets that facilitate viral replication and tumorigenesis. "I think this work underlines the importance of Fbw7 as an emerging tumor suppressor and the consequences of its loss in tumors," Dr. Welcker emph...

Drug That 'Tags' Decision-making Areas Of The Brain May Aid

...entists, the new drug ?Nifrolidine ?is a selective binding agentthat identifies specific areas of the brain responsible fordecision-making, learning and memory. Lead researcher JogeshwarMukherjee, UCI associate professor of psychiatry and human behavior,developed Nifrolidine to measure a subtype of nicotine ...

Researchers Uncover Key Step In Manufacture of Memory Protein

...holesterol-rich molecules known as lipids. If this binding process does not take place, proBDNF cannot be converted to its active form. Dr. Loh explained that the proBDNF molecule has four projections, resembling prongs. These prongs fit into a corresponding indentation on CPE, analogous to the way a plug fo...

New Technique for Tracking Gene Regulators

...issue of Cell, where they describe thehuman-genome binding sites of a regulator protein known as CREB.“Though...h theregion around the specific locations for CREB binding sequences orgenes that might be regulated by CREB.Using this technique, the scientists have identifi...

Novel Enzyme Shows Potential As An Anti-HIV Target

...nscription factors, Tat activates transcription by binding to RNA, specifically to a bulging “stem-loop?struc...led the trans-acting responsive element (TAR). Tat binding to TAR requires recruiting the enzyme cyclin-dependent kinase 9 (CDK-9) to the HIV promoter (where t...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

... cell death. "The let-7 microRNA regulates Ras by binding to the message for Ras and likely inhibits transla...is identical to the sequence in the worm, and both binding site and pathway for Ras are highly conserved. Tissue from lung cancer tumors, compared with their ...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...iling arrays to map new human transcription factor binding sites ...

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine

...acterium known to use CbpA to invade humancells by binding to pIgR, according to Richard W. Kriwacki, Ph.D.,a...svaccines for children must instead be modified by binding thosecarbohydrates to special proteins that stimulate the immune systems ofyoung children. “However ...

New comparative toxicogenomics database

...acterium known to use CbpA to invade humancells by binding to pIgR, according to Richard W. Kriwacki, Ph.D.,a...svaccines for children must instead be modified by binding thosecarbohydrates to special proteins that stimulate the immune systems ofyoung children. “However ...

Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease

...tchev's research group, that clarify the nature of binding forces between amyloid molecules. The poster session will take place March 16, 2005, 7:30 - 10 p.m. Pacific Standard Time, in Hall D of the San Diego Convention Center. This work was funded by the Camille and Henry Dreyfus Foundation and by Duke Uni...

UCSD discovery may help extend life of natural pesticide

...that there was either zero or dramatically reduced binding of glycolipids to Bt toxin. They concluded that the defective sugar structure of the glycolipid receptor in each of the mutants prevents Bt from binding. Other members of the research team, coauthors Stuart Haslam and Anne Dell, biologists at Imperi...

Scientists discover that host cell lipids facilitate bacterial movement

.... PIP2 and PIP3 also prevent capping proteins from binding to the ends of actin filaments, allowing new actin... Dr. Southwick. "Most signals arise from molecules binding receptors on the outside of the cell. In the case of Listeria, we find that this intracellular patho...

Scientists solve structure of key protein in innate immune response

... Dr. Lee. "We propose that this pocket is the main binding site for LPS because previous biochemical studies ...4 binding. Therefore, they probably share the same binding pocket with LPS." Ligands other than LPS can be accommodated in the pocket due to its large size, t...

How an AIDS-Related Cancer Unleashes Inflammation

... it had no enzymatic function itself, but acted by binding to or activating other proteins," he said. Thus, ... In further experiments, they discovered that the binding of kaposin B activated MK2, leading to higher levels of cytokines in the cell. Activated MK2 does th...

Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

...ek a cancer cell to bind to instead of its natural binding partner. Then they invented a "molecular tag" that they attached to structures on the outside of the cancer-seeking measles virus. This tag is the key innovation of their work and central to the success of the team's investigation. It enables researc...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

...eceptors, may also be controlled by SUMO since the binding site is present in those proteins although not yet proven to operate. "Cells are fastidious in the way they regulate activity at their borders," Goldstein added. "Our work shows how sumoylation controls one important process at the cell surface and ...

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