Scientists identify genetic pathways essential to RNA interference
...otally unexpected, suggests a potential connection between RNAi and the control of cell division in cancer." The researchers note that better understanding the mechanisms underlying RNAi could help transform what has been a research tool into a powerful therapeutic tool. Although the process has worked well...Brain-mapping technique aids understanding of sleep, wakefulness
...ne side to the other and maintain a proper balance between time spent awake and time spent asleep is still a big mystery in brain science. By shedding light on the network of neural connections involved in sleep, he said, his and other studies will help unravel the mechanisms involved in sleep homoeostasis. ...Revolutionary nanotechnology illuminates brain cells at work
...s of GFP. The cyan is excited and, if the distance between the colored proteins changes, more or less energy is transferred to the yellow protein. In this study, the cyan and yellow proteins behave as if they move away from one another when the sensor recognizes glutamate. Thus, there is more cyan and less y...Super predators and mass extinctions
...he lower the mutation rate, the longer the periods between super predators. For a sufficiently low mutation rate, the model can lead to cycles that correspond to our 26 million year mass extinctions. Previous models that do not show these sorts of cycles could be faulty, according to Lipowski, because they ......assembly of a large, springy molecular scaffolding between the receptor towers. The interlocking system grips and pulls the receptors towards each other until they collapse inward like overloaded laundry lines. The stressed receptors become engulfed by the cell, and thus cease signaling. In response, the cel...Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
...among Hurler's children who receive bone marrow is between 63 and 72 percent. ...Discovery may lead to better Candidiasis drug
...ut of, cells. Ions regulate electrostatic pressure between the cells' internal and external environments, which, in turn, regulates their volume and water content. Cells that lose their water content without being able to regulate its re-uptake die rapidly, Edgerton said. "Now that the target for histatin h...NASA study finds snow melt causes large ocean plant blooms
...fferences in both temperature and pressure systems between the Indian subcontinent and the Arabian Sea. The p...in summer creating a larger temperature difference between the water of the Arabian Sea and the Indian subcontinent landmass. The temperature difference is re...Small species back-up giant marsupial climate change extinction claim
...gafauna roamed the globe in the Pleistocene epoch, between 1.8 million and 10,000 years ago. In the northern...t marsupials ruled. Current theories suggest that between 50,000 and 20,000 years ago, increasing aridity in Australia led to cooler and drier conditions that...White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role
...ent of the feedback circuit regulating the balance between neutrophil production and destruction. The research, published in the March issue of Immunity, suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that contro...Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes
...l disease. Indeed, there was a direct relationship between the diameter of the basilar artery, the cranial ar.... "This study is the first to show an association between intracranial arterial dolichoectasia and the whole spectrum of small vessel disease abnormalities, t......most effective strategies is a cooperative process between institutions, called twinning, which is already in place in Central and South America, Africa and Southeast Asia, thanks to the efforts of the International Society of Pediatric Oncology, several institutions in Europe and St. Jude Children’s Researc...Same-Sex Mating Discovered in a Toxic Fungus
...type of sexual cycle, allowing sexual reproduction between members of the same mating type," he added. "That ...lls followed by meiosis, enabling genetic exchange between members of the same sex, they reported. Meiosis is the process whereby cells divide into two "haplo...Potential Drug Target For Treating Cocaine Abuse Found
...ws this may not be true. "In fact, the interaction between dopamine trans-porters and the substances that bind to them may depend on the chemical structure of those substances," says NIDA's Amy Newman, who synthesized the compound. The researchers found that their novel drug made contact with transporters sl...Youth With HIV Take More Risks After New Meds Introduced
...h Behavior. A group of HIV-positive youth studied between 1999 and 2000 reported having more sexual partners... and more drug use than HIV-positive youth studied between 1994 and 1996, say Marguerita Lightfoot, Ph.D. and colleagues at the UCLA AIDS Institute at the Davi...CoPub Mapper: mining MEDLINE based on search term co-publication
...rest. In order to identify biological similarities between genes, publications from MEDLINE were identified in which pairs of gene names and combinations of gene name with specific keywords were co-mentioned. MEDLINE search strings for 15,621 known genes and 3,731 keywords were generated and validated. PubM...Medical whistleblowers speak out
...ne. One of the lessons, says Lenzer, is that "ties between drug regulators and industry may influence new dru... Congress - has shone light on how the "synchrony" between the pharmaceutical industry and the medical enterprise may be compromising the integrity of American...Canada approves marijuana-based pain spray
...“This is very important since pain severity varies between different patients and even in the same patient at...re diagnosed. MS is most often diagnosed in people between the ages of 20 to 40 years of age. ...Different microarray systems more alike than previously thought
...mine whether seemingly minor remaining differences between platforms show a pattern that could affect a researchers' choice in consideration of cost versus performance in a given experiment. Additional studies can also include more recently introduced versions of microarray platforms. The research was funde......hat there would be different regulatory mechanisms between the two gene types, but it's amazing how well the data support this tuning model," said Berman. "The study is important for our understanding of schizophrenia because it clarifies the neural mechanism for a well-established risk gene." Also particip...