Mitochondrial DNA mutations play significant role in prostate cancer
...ed cancer who had undergoneradical prostatectomies between 1995 and 2002, and 54 tissue samplesfrom patients who had prostate biopsies but were found to be cancerfree. Twelve percent of all the prostate cancer samples had mutationsin the COI gene, while less than 2 percent of the samples from patientsfound t...Molecular machine may lead to new drugs to combat human diseases
...is unreactive but reveals many of the interactions between the RNA and the molecules that it activates, she said. "Knowing the structure can help us engineer molecules to behave better," Golden said. "It's very hard to find targets in cells because cells are organized in ways we still don't fully understand...Sea skate experiment sheds light on human cell transport
...ed into cell membranes ?and glucose can't be moved between cells. And when channels are blocked, damaged cel... against cancer. "There is a possible relationship between operation of these channels and the uncontrolled multiplication of cancer cells," Goldstein said. "I...Color-blind method opens new doors in DNA sequencing
...sist in deciphering the signals, this "cross-talk" between the dyes results in subtle variations that can cau...le spectrum, eliminating the problem of cross-talk between dyes, said Metzker. Because there are four lasers, scientists can manipulate the system so that eac...New Clues Add 40,000 Years to Age of Human Species
...story in that part of the world. “The correlation between the Kibish deposits and the Mediterranean sapropels not only helps us resolve an anthropological mystery, but it provides a whole new perspective on the history of the Turkana Basin, a setting that has provided so much important evidence regarding h...Enzyme allows B cells to resist death, leading to leukemia
...vels and activity ?suggesting a direct correlation between high Lynactivity and the ability of these B cells to resist apoptosis. Theauthors suggest that Lyn is involved in the development of B-CLL andthat this enzyme therefore represents an attractive target for therapy.The study will appear online on Janua...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...RI scan ?researchers found significant differences between the patients' scans. Some areas reflected an increase in water diffusion, suggesting tumor cell death; other areas saw a decrease in diffusion, which Ross said could be accounted for by the swelling some cells undergo before dying; and in some partic...Gene variations explain drug dose required to control seizures
...treatment of epilepsy to patients' genetic makeup, between the Department of Clinical and Experimental Epilep...establishes the principle that genetic differences between patients do influence variation in response to anti-epileptic drugs for patients with epilepsy. "In...Solution to Pollution: New Bacteria Eats Toxic Waste
...; The research involves many levels of cooperation between the sciences and engineering fields but also extends to social scientists and economists. Utah State undergraduates and graduate students from the Colleges of Engineering and Science are also participating in the project. The researchers said student...Scientists collaborate to assess health of global environment
...taling nearly 2,500 pages and focusing on the ties between ecosystems and human well-being. A set of 33 case studies, termed sub-global assessments, also will be released in late 2005 or early 2006. Each case study will focus on a particular area, Mooney said. "This is really important because the global vi...BRCA1 causes ovarian cancer through indirect, biochemical route
...lly acts indirectly, that it disrupts interactions between different cell types." The well-known breast cancer gene, BRCA1, not only gives carriers of its mutated form a four in five chance of developing breast cancer, it also confers a 40 percent risk of developing ovarian cancer by the age of 70. How that...Scientists decipher genome of fungus that can cause life-threatening infections
...ccount for the genome rearrangementsoften observed between different Cryptococcus isolates.TIGR's Fraser says the Cryptococcus genome sequence will benefit a widerange of biomedical research into the increasingly significant humanpathogen. Stanford's Hyman says, "The two new Cryoptococcus genomesequences and...Needling Chromosomes Reveals Cell Division Secret
.... The exquisite management of adhesion properties between newly divided chromosomes, called chromatids, is c...dia set out to use micromanipulation todistinguish between visible separateness and physical separateness."To study chromatid adhesion, Paliulis mastered the h...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...he says. "But what we learn about the interactions between chromatin, its tags, and various proteins that interact with them may one day be useful for understanding, diagnosing, and even developing new treatments for some cancers." ...New research questions basic tenet of neuron function
...elease them when needed into the synapse, or space between nerve cells, where the chemical signal is transmitted to other neurons. It is known that synaptic vesicles release their neurotransmitters in two different "modes" ?one when the neuron is stimulated and actively relaying a message, and the other thr...New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
...ipts derived from the sparsely transcribed regions between centers of dense transcription are non-polyA transcripts. This study focused on an in depth scan of 10 chromosomes; however, Affymetrix has developed tiling microarrays that cover all human chromosomes. GeneChip tiling microarrays have been used by ......n." In fact, in a mouse model, the analogues were between 91 to 99 percent effective in stopping the spread of breast cancer cells, the researchers report. Cell culture studies suggest they can reproduce that success in a wide range of other cancers, too. "What's unique about these analogues is that they d...ASU researchers finds novel chemistry at work to provide parrot's vibrant red colors
...s interested in learning more about the connection between the red colors and anti-oxidants within and among parrot species, as well as "to specifically explore the balance of naturally and sexually selected costs and benefits to becoming colorful. "Parrots are unusual among birds, in that they almost witho...Transport System Smuggles Medicines Into Brain
...s interested in learning more about the connection between the red colors and anti-oxidants within and among parrot species, as well as "to specifically explore the balance of naturally and sexually selected costs and benefits to becoming colorful. "Parrots are unusual among birds, in that they almost witho......ly a place for nutrient exchange and waste removal between mother and fetus. But rather than merely providing nutrients, Orkin says, the placenta may also provide an ''infusion'' of blood stem cells to the fetus. ''This research reveals a new organ for blood development,'' Orkin says. ''It is surprising tha...