New understanding of DNA repair may pave way to cancer treatments
...xpected to disturb the otherwise conserved balance between its role in gene regulation and the DNA damage response. We need to find out which of the two functions is more dominant under these circumstances in order to devise ways to regain the proper balance," he said. The Ronai lab's work on ATF2 was start...Cerebral navigation: How do nerve fibers know what direction to grow in?
...o engulf the ephrin-Eph complex, breaking the bond between the two and repelling the axon, causing it to turn away. When mice were genetically modified to lack Vav2 and the related Vav3, thereby eliminating this repellent signal, the mice had abnormal axon projections and defects in neural circuitry formatio...Live vaccines more effective against horse herpes virus
...th. The virus is spread mainly by intimate contact between horses. Once infected, a horse carries the virus for the rest of its life in a "latent" (dormant) state. The same symptoms from the initial infection can be reactivated by stress later in life. Osterrieder will present his new findings on vaccine ef...Study: 'homemade' gene expression technology unreliable
...e organs. According to the study, reproducibility between platforms and across laboratories was generally poor, but reproducibility between laboratories dramatically increased to acceptable levels when a commercial microarray was used with ...Global analysis of membrane proteins
...s been made possible through a close collaboration between biochemists at Stockholm University and bioinformaticians at Stockholm Bioinformatics Center. The project has been supported by the Swedish Research Council, the Swedish Cancer Foundation, the Foundation for Strategic Research, the Knowledge Foundat...Scientists journey to southern Africa to unravel the secret world of elephant communication
...phants have generally been coming to the waterhole between noon and midnight, so all the cooking and major no.... "We wanted to determine if they can discriminate between familiar and unfamiliar calls that are played back as seismic signals," O'Connell-Rodwell explains. ...Biomarkers isolated from saliva successfully predict oral and breast cancer
...man mRNA from saliva, setting up a comparison test between cancer patients and the normal subjects based on analysis of their genetic "profiles." "Both serum and saliva exhibited unique genetic profiles," said Wong. "The risk model yielded a predictive power of 95 percent by using only the salivary transcri...Mouse gene shows new mechanism behind cardiac infarction in man
...g will spur further research into the relationship between the protein and cardiac infarction. Hopefully it will offer a new therapeutic technique for the treatment of atherosclerosis and thus reduce the risk of cardiac infarction. ...Researchers discover underwater volcano
...s. Such hazards may include the explosive reaction between red-hot lava and seawater, or tsunamis that may be... the first ever student-to-student videoconference between a high school and a research vessel with the help of HiSeasNet, a satellite communications system th...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...r efficacy." The study was a collaborative effort between the laboratory of Timothy J. Triche, at Children's Hospital of Los Angeles; and the laboratory of Mark E. Davis, at the Caltech. Also participating in the study were Jeremy D. Heidel and Derek W. Barlett, both at Caltech. Support for this research c...At long last, scientists figure out how plants grow
...ng on the repressed gene. "The key interaction is between TIR1 and the repressor," Estelle said. "Nihal was able to get that to work in a test tube, but the interaction would only occur if he added auxin to the solution." Auxin may stick around awhile, but it is eventually broken down by natural cell proce...Roots Engage in Underground Chemical Warfare
...overed a critical aspect of the battle that occurs between plants and microbes. ...Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
... these organisms, the key role of the interactions between vibrios and the immune system of bivalves has been...n insight into the complexity of signals that pass between vibrios and bivalve host cells and helps to explain how these processes develop in natural condition...MUHC scientists describe genetic resistance to rampant virus
...sm of resistance to CMV, involving the interaction between two genes. One gene flags virus-infected cells for destruction, the other gene allows our Natural Killers cells to recognize and terminate them. "This is a new concept in natural disease resistance," notes Dr. Vidal. "Our research suggests there are ...New project aims to make large-scale lobster farms feasible
...in huge single-file lines when crossing open areas between island coasts and reefs, will be the focus of the next Harbor Branch Ocean Science Lecture Series event, on March 9. "Spiny lobsters are one of the most highly-prized fisheries species in the world, and especially in our Florida waters," said Megan ...Undesirable expatriates: Preventing the spread of invasive animals
...zed bird, mammal and freshwater fish introductions between Europe and North America. Jeschke comments, "We fo...e valuable pelts-- humans have been moving animals between Europe and North America for hundreds of years. Enterprising furriers imported American mink into Eu...NYU and MSKCC research provides model for understanding chemically induced cancer initiation
...y linked with cigarette smoke. This molecular link between chemical DNA damage and cigarette-associated lung ...re in which the carcinogenic residue is sandwiched between adjacent base pairs in the double helix. "Such conformational differences in methylated and unmethy...NIAID begins clinical trial of West Nile virus vaccine
...ongoing trials at NIH. Fifteen healthy volunteers between the ages of 18 and 50 will receive three injections of the DNA vaccine into the upper arm: one at the start of the trial, a second approximately four weeks later, and a third approximately four weeks after that. To help force the DNA plasmid into mus...Oceans more vulnerable to agricultural runoff than previously thought, study finds
...tists have documented a "one-to-one correspondence between an irrigation event and a massive algal bloom." Red tides and dead zones According to the researchers, artificially induced algal blooms could have major impacts on recreational and commercial fishing, major industries in the gulf. Red tides, for e...... a three-foot snowfall in late April. "PennDOT is between a rock and a hard place," says Silver. "Everyone knows that the salt is not good for the environment, but salting roads is a huge safety issue in a part of the country that gets 10 to 12 feet of snow every winter." Silver's research does show a larg...