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A gene's first 'kiss' sets off that affair known as puberty

...dhood hibernation. Within 30 minutes of kisspeptin being administered to male monkeys, LH, one of the hormones stimulated by GnRH secretion, was no longer dormant, with levels 25-times higher than its baseline of zero. In addition to Dr. Plant, other authors of the PNAS paper are Muhammad Shahab, Ph.D., f...

New push for public health, AIDS spending at African Union summit

...tion (WHO) says just 310,000 people in Africa were being treated with a cocktail of antiretroviral (ARV) drugs that inhibit the progression of their disease, which has no known cure. But demand for free drugs vastly outstrips their supply, the cost of the drugs - at some $US600 annually for the rest of a ...

Genes In The Interferon System Important In Systemic Lupus Erythematosus

...alSciences at Uppsala University. The findings are being published todayon the Web page of the highly prestigious American Journal of HumanGenetics. "These findings are probably the first genetic pieces of ahuge 'interferon puzzle,' with whose help it will be possible todiscover the mechanisms behind the d...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

...h the cells are inserted into thestructures.Before being fed into the printer, the cells are suspended in anutrient rich liquid not dissimilar to ink, which ensures theirsurvival. The cells are then fed into the printer and seeded directlyinto the structure as it is built. This avoids any 'sticking to thes...

Dysentery uses 'sword and shield' to cause infection

...s a shield to protect the dysentery bacterium from being destroyed by the body's immune system. Dr Christo...ectively. We have shown why the bacteria can avoid being destroyed by the body's immune responses through the expression of a molecule that acts as a shield ...

Priming embryonic stem cells to fulfill their promise

...onicstem cells into the types of specialized cells being sought as possibletreatments for dozens of human diseases and health conditions. SangeetaBhatia and Shu Chien, UCSD bioengineering professors, and ChristopherJ. Flaim, a bioengineering graduate student, described the cell-culturetechnique in a paper ...

Controversial drug shown to act on brain protein to cut alcohol use

...self decreases alcohol consumption.The research is being published in the January 19 issue of The Journalof Neuroscience."By identifying the brain protein that Ibogaine regulates to reducealcohol consumption in rats, we have established a link between GDNFand reversal of addiction -- knowledge of a molecul...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...with Neu5Gc became, effectively, likeanimal cells, being attacked by human antibodies, and thus renderingth...ecently produced such a mouse. Another possibility being attempted bygroups in other parts of the world is to use human embryo-derivedconnective tissue cells...

UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims

...ceutical ads. We wanted to see what documents were being used to substantiate the claims and how accessible these were to physicians who may want to verify the research findings," said lead author Dr. Richelle Cooper, assistant clinical professor, Division of Emergency Medicine, David Geffen School of Medi...

Mouse brain cells rapidly recover after Alzheimer's plaques are cleared

...ill occur inhumans. Abeta antibodies are currently being considered for use inAlzheimer's patients in clinical trials.In the mice, the largest swellings were least likely to heal. Brendzaplans to look into whether additional treatment can prompt theirrecovery.Holtzman and Brendza plan to continue using the...

Key molecule in plant photo-protection identified

...ill occur inhumans. Abeta antibodies are currently being considered for use inAlzheimer's patients in clinical trials.In the mice, the largest swellings were least likely to heal. Brendzaplans to look into whether additional treatment can prompt theirrecovery.Holtzman and Brendza plan to continue using the...

Timing is everything: First step in protein building revealed

...icating a much bigger separation.To prove eIF1 was being released from the ribosome complex, theresearchers examined how fast the pieces of the ribosome come together,and how long it takes them to fall apart under various circumstances.Their results support the idea that two separate steps take place oncet...

Tiny particles could solve billion-dollar problem

...re found on the surface of the particle instead of being locked away inside the metal where they cannot interact with other chemicals. For example, in the bulk palladium, less than 4 percent of the palladium atoms were on surface of the particle. Pure palladium nanoparticles had 24 percent of the metal on ...

Plants respond similarly to signals from friends, enemies

...interactions with other organisms like rhizobia is being exploited by nematodes," says Dr. David Bird, associate professor of plant pathology, co-director of NC State's Center for the Biology of Nematode Parasitism and co-author of the paper. "Nematodes have not only found a weak link in plants but may be ...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

...moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting better and we are getting more reproducible results.? Researchers worldwide are excited about the notion of using protein “barcodes?to identify individual cancers before symptoms appe...

New species from old data

...moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting better and we are getting more reproducible results.? Researchers worldwide are excited about the notion of using protein “barcodes?to identify individual cancers before symptoms appe...

Cracking the olfactory code in bees

...moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting better and we are getting more reproducible results.? Researchers worldwide are excited about the notion of using protein “barcodes?to identify individual cancers before symptoms appe...

Signaling protein builds bigger, better bones in mice

...moving in that direction,?he adds. “The technology being used to develop a variety of proteomic diagnostic tests is getting better and we are getting more reproducible results.? Researchers worldwide are excited about the notion of using protein “barcodes?to identify individual cancers before symptoms appe...

Computers to be used to find blueprint for new influenza drug

...op the disease developing. The drug would work by being chemically very similar to part of the protective coating around the cells in our throats that the flu virus first attacks when a person becomes infected. The flu virus would be deceived into attacking the drug, called an inhibitor, instead of the ce...

A much-needed shot in the arm for HIV vaccine development

...oposal."The PLoS Medicine editors hail the plan as being a "crucially importantoutline for vaccine development." But in their editorial, they alsocaution that "the goodwill surrounding it won't last unless it isquickly followed up with a set of milestones, and a transparent processby which successes and fa...

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