Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
...g length and quality of life for many CF patients, before CF gene therapy becomes a reality. The Penn research team demonstrated the disruptive action of SMase in frog oocytes (egg cells) engineered to place CFTR in their membrane. These oocytes are an experimental tool that allows the researchers to ass...Sleep disturbances affect classroom performance
... Do not go to bed hungry, but don’t eat a big meal before bedtime either. Avoid any rigorous exercise within six hours of your bedtime. Try to get rid of or deal with things that make you worry. Make your bedroom quiet, dark and a little bit cool. ...Sleep enforces the temporal sequence in memory
...e in such memories: did Paul spill a glass of wine before or after Mary left the party? Previous findings ...d by presenting one word and asking which one came before and which one came after during learning. Sleep was found to enhance word recall, but only when the ...Researchers discover new details about HIV-1 entry and infection
...V-1 while LC may harbor viable virus for some time before spreading it to other cells. These results reveal that it is necessary to consider mechanisms of viral entry into both CD4+ T and LC when searching for an effective way to interfere with infection through the vaginal epithelium. "Our findings prov...Chemical switch triggers critical cell activities
...the fleeting moment when E2 is next to NEDD8, just before it falls off and carries NEDD8 with it. To do that, Schulman's team first had to prevent E2 from binding with NEDD8, so it would not fall away from E1. The investigators used a mutated form of E2 that binds to the docking site and gets near NEDD8, bu...Stem cell transplants explored at Stanford as a possible treatment for hearing loss
...o place your bets on. "Everyone asks, 'How long before we do this?'" said Heller, PhD, associate professor of otolaryngology, whose accent still bears the trace of his native Germany. "I tell them the devil is in the details." But even at the national level, those in the research community remain h...Penn researchers replace organ in adult mice using 'single-parent' stem cells
... embryonic stem cells entirely in the culture dish before transplanting them. The Penn researchers believe that using uniparental embryonic stem cells as a tissue source could provide a major advance in the alleviation of human disease, provided these results can be translated into human studies. ...Nanotechnology shows promise as next wrinkle fighter
... On all fronts, it's all about nailing a wrinkle before it starts. "Everything starts at a really small scale, so if we can prevent the buckling at the very beginning ?at the nano level ?we can eliminate large scale wrinkles," Ilsoon said. "Wrinkles can initiate from the small scale, and when it grows w...Cancer researchers add spice to research against rare neuromuscular disease
...effectiveness, through clinical studies in people, before it can be considered as a possible treatment for any disease. "The compound we are studying has been significantly modified from the original ingredient found in food like curry or ginger," said Chang, a faculty member in the departments of Urolog...Computer imaging assists with facial reconstructive surgery
...or plastic surgeons to accurately analyze the face before surgery so that afterward, prominent facial features such as the chin and nose are balanced in relation to the structures around them. “Even a well-executed surgery will result in a poor aesthetic result if inaccurate analysis leads to an improper d...New bird, bat species revealed by extensive DNA barcode studies
...ls?genetic information ?ever since 1947, six years before its structure was described by Watson and Crick. H...y," the 82-year-old professor emeritus says. "Just before my laboratory was closed, my team of researchers was studying the number of genes responsible for sp...Cancer that colonizes our bodies
...ls?genetic information ?ever since 1947, six years before its structure was described by Watson and Crick. H...y," the 82-year-old professor emeritus says. "Just before my laboratory was closed, my team of researchers was studying the number of genes responsible for sp...Health Canada approves cold and flu medicine
...nologies published and unpublished data on COLD-fx before approving the claims. The NHPD issues product licenses in several categories. Because COLD-fX® is a unique patented product, it was issued an NPN in the non-traditional category, which requires the highest level of scientific evidence. In contra...Long-term narcotics use for back pain may be ineffective and lead to abuse
...is generally weak and more studies need to be done before firm conclusions can be made," said Martell....Long-lived deep-sea fishes imperiled by technology, overfishing
...ve sense, they have to wait for the stars to align before they successfully produce offspring that will survive until maturity." Natural and human-influenced climate factors including El Niño, the Pacific Decadal Oscillation and hypoxia zones all can influence shallow-water fishes' breeding and mortality...Biologists produce global map of plant biodiversity
...ive to extinction plants that hold important cures before we find them," says Kreft, a biologist at the Nees Institute for Biodiversity of Plants at the University of Bonn. "Ecological research like ours that captures complex diversity - environment relationships on a global scale may assist in a small, but...New research may overturn conventional wisdom on drug-resistant tuberculosis
...ed on 38 patients from whom samples were available before and during treatment. The researchers found that the strains of TB in the samples taken before treatment were genetically different from those taken during treatment in 87 percent (33 out of 38) ...DNA analysis reveals rapid population shift among Pleistocene cave bears
... for a time, they endured only another 2,000 years before becoming extinct in the region. ...Twenty of world's 162 grouper species threatened with extinction
...fe, making them particularly vulnerable to fishing before they mature. In addition, commercial fishing that targets reproductive gatherings of adults further hinders replenishment of unmanaged populations. The threatened groupers include two species of coral trout grouper, which are mainstays of the live......bility of a major hurricane hitting the U.S. coast before the season ends on November 30. "Coastal areas ... access and communication should be put into place before the storm hits to meet both the short-term goals of salvage and fire prevention and the long-term go...