Tumor-suppressor gene is critical for placenta development
...ger than the embryos missing Rb only, but all died before birth. "This showed that the interaction of these two proteins is definitely important," Leone says. "It strongly suggests that E2f3 is a key player in mediating Rb function in stem cells and possibly in its role as a tumor suppressor." Next, L...Putting an old drug to a new use
...ead to organ failure and even death if not treated before irreversible damage has occurred. Researchers from the Innsbruck Medical University, the University of Heidelberg, Germany, and the European Molecular Biology Laboratory (EMBL) now made a surprising discovery that may lead to new therapeutic approach...University of Alberta researchers unravel intricate animal patterns
... describe new patterns that have not been reported before such as zigzag pulses, feathers and traveling breathers. This model doesn’t apply to specific species, says Eftimie. "However, we can think of those flocks of birds that fly in one direction, and then suddenly change direction 180 degrees, and com...Darwin's famous finches and Venter's marine microbes
...this trove of sequences now, but it may be decades before we fully understand it all." Just like the famo...hn Gould who had to classify the Galápagos finches before they led Darwin on the right track, Manning and many others have been busy during the last couple of...Scientists discover stage at which an embryonic cell is fated to become a stem cell
...ic cells are already apparent at the 4-cell-stage, before the cells become partitioned between the inside or outside of the embryo. And those differences depend on the orientation and order of the very first cleavage divisions of the embryo. Professor Zernicka-Goetz said, "Our findings were surprising si...Ancient amphibians evolved a bite before migrating to dry land
...c amphibians developed the ability to feed on land before completing the transition to terrestrial life, res...e analysis suggests that amphibians evolved a bite before emerging onto land as fully terrestrial animals." ...New findings blow a decade of assumptions out of the water
...ting in cold air. The house could get quite chilly before the draft reaches the thermostat and the furnace turns on. But if the thermostat is in the same room as the window, the furnace will turn on and even out the temperature much faster. In his research Deutsch used a novel analysis of surface nutrien...Scientists find potential 'off-switch' for HIV virus
...ls all by themselves, but the cell is usually dead before it can happen," Weinberger said. "If we can create drugs that target these enzymes, perhaps we can get SirT1 and related enzymes to assert themselves immediately, forcing HIV into hibernation with high frequency and reducing the threat to the host." ...Scripps research study reveals structural dynamics of single prion molecules
...tein fluctuates among several different structures before forming intermediate shapes during the amyloid assembly process. The intermediate stages of the process are critically important, Deniz noted: "No single native unfolded protein is capable of initiating the amyloid cascade because of this constan...UCSF brain tumor vaccine trial shows promising results
...er system, Parsa performed surgery, just four days before Christmas. He removed all but a very small amount of tumor that was near an area that could affect her speech. The removed tissue was sent to Antigenics, the Massachusetts biotech company that produces the vaccine from the patient’s tumor tissue. Al......om West Africa were cracking nuts with stone tools before the advent of agriculture, thousands of years ago. The result suggests chimpanzees developed this behaviour on their own, or even that stone tool use was a trait inherited from our common ancestor. Julio Mercader, Christophe Boesch and colleagues fou...World's largest flower evolved from family of much tinier blooms
...Joseph Arnold, a naturalist and physician. Shortly before Arnold died of malaria on that same expedition, he described rafflesia as "the greatest prodigy of the vegetable world," adding, "To tell you the truth, had I been alone, and had there been no witnesses, I should think I would have been fearful of me...Exploring the molecular origin of blood clot flexibility
...uld stretch four to five times its original length before snapping. "This is among the most extensible, or s...w levels of mechanical force. But "it wasn't known before that the coiled coil region of the fibrinogen molecule would be the part to unfold under the stress ...Post oak grasshoppers emerging
...They go through at least five developmental stages before becoming adults, all the while munching on leaves. Currently, they are still in the pre-adult stage, he said. The grasshoppers prefer post oaks, but Behmer has heard reports of them feeding on other oak and hickory trees, even defoliating them. ...RNA enzyme structure offers a glimpse into the origins of life
...ersions of the ribozyme under different conditions before he succeeded. Using x-ray crystallography--which involves shining a beam of x-rays through the crystals and analyzing the resulting diffraction patterns--Robertson and Scott were then able to determine the three-dimensional structure of the ribozyme....Biologists prove critical step in membrane fusion
.... What about the membranes? What do they look like before vesicle cargo is released? Wessel and his collaborators discovered that the membranes of the egg and the vesicles are hemifused ?a state where the membranes are shared but the contents remain separate. Using fluorescent dyes and a high-resolution ...FSU researchers determine a critical factor in workings of proteins
..., a phase that two associating proteins go through before finally becoming a specific complex. The rate prediction is broken into two parts: how much the rate would be if the proteins find each other purely through random motion, and how much electrical attraction increases the rate. "This theory opens n...Selective marker found to indicate aggressive form of breast cancer
...of a biomarker and, in doing so, detect the cancer before it has a chance to come back." Basal epithelial tumors lack important molecular targets such as the estrogen receptor, progesterone receptor and Her2. This not only makes positive diagnosis difficult, say researchers, but also eliminates several ...Lost dogs found more often than lost cats, study suggests
...rd, adding that cat owners waited about three days before contacting a local animal shelter, while dog owner...rd, adding that cat owners waited about three days before contacting a local animal shelter, while dog owners waited about a day to do so. "The cats that st...Antarctic warming to reduce animals at base of ecosystem, shift some penguin populations southward
...he Eemian warming period ?a time 130,000 years ago before the last major glacial stage. "We know that the climate was warmer then, sea levels were higher by a couple of meters compared to today. Lyons points to the fact that all the global climate models predict a warming in the Antarctic and a decrease...