Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...her thinking. "Myhypothesis was this: While it had been proven that individually thechemicals don't impact nerve cell development, the combination of allthree might pose increased risks," she says.So Reinisch decided to test the chemical cocktail, in similarproportions to those found in Brick, on a specie...Automatic extraction of gene/protein biological functions from biomedical text
...nformation related to gene functions from text has been increasing. Results: We have developed a method for automatically extracting the biological process functions of genes/protein/families based on Gene Ontology (GO) from text using a shallow parser and sentence structure analysis techniques. When the...New Clues Add 40,000 Years to Age of Human Species
...ia. “For several decades, the Kibish fossils have been a key element in arguments for an ancient origin of modern humans in Africa, yet one for which the age and provenance of the fossils was repeatedly contested,?notes Fleagle. At the request of their Ethiopian colleague Zelalem Assefa, now at the Nati...A bacterial genome reveals new targets to combat infectious disease
...s enumerate a variety of pathways that have either been degraded or preserved, and highlight patterns in t... nematode infection. Since no new antifilarial has been developed in two decades, these results may quickly lead to new therapeutic strategies against these...Gene variations explain drug dose required to control seizures
...ses of both carbamazepine and phenytoin. SCN1A has been implicated in many inherited forms of epilepsy and is the drug target for phenytoin. Given its relationship to both anti-epileptic drugs tested, the SCN1A variant may be of particular importance for understanding patient response to drug treatment, ...Solution to Pollution: New Bacteria Eats Toxic Waste
...cyclic aromatic hydrocarbons (PAH’s). The site had been used by industry as a place to apply preservatives.... Because few of these mycobacterium isolates have been characterized genetically, Utah State’s Center for Integrated Biosystems funded the biologists to ex...Scientists collaborate to assess health of global environment
... well-being. And surprisingly enough, that's never been done before." Mooney will participate in the Marc... of the 24 services the assessment considered have been degraded over the last 50 years--most notably fresh water, fisheries, air and water purification, an...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
... altered mice in which the gene for the enzyme had been rendered nonfunctional, the researchers demonstrat...e disease, Koeberl said. "A number of babies have been receiving enzyme replacement therapy for several years," said Koeberl. "They are walking, living lon...Enzyme shown to help protect genomic stability
...he ends of the chromosomes known as telomeres, has been linked to aging in humans and an elevated risk for...oves acetyl molecules from histones. Sir2 has also been associated with promoting genomic stability, and some studies have linked it intriguingly to the agi...BRCA1 causes ovarian cancer through indirect, biochemical route
...age of 70. How that risk is imparted, however, had been harder to pin down. "We've known for a long time ...n, once the chemical messenger that's affected has been identified, it will be much easier to diagnose a predisposition to ovarian cancer or pinpoint just w...Scientists decipher genome of fungus that can cause life-threatening infections
...tributes, environmental distribution andwhich have been diverging over millions of years of evolution....Needling Chromosomes Reveals Cell Division Secret
...etached from one another at that time."What hadn’t been done was to attempt to separate chromatids todirectly determine whether they, in fact, are held together or not,"said Nicklas. "So, Leocadia set out to use micromanipulation todistinguish between visible separateness and physical separateness."To stu...Purdue proves concept of using nano-materials for drug discovery
...re possible with a small amount of protein. "It's been very hard to study these proteins because they are difficult to produce in large quantities," Lee said. "The devices we have created offer the promise of making chips capable of running thousands of reactions with the same amount of protein now neede...In the sea slug's defense against lobsters, confusion is key
... involve modes of trickery that had not previously been appreciated as components of chemical defense. When attacked by predatory spiny lobsters, sea slugs (also known as sea hares) release an inky secretion, termed ink and opaline, from a pair of glands. The new findings show that Aplysia's defensive se...Scientists discover the cellular roots of graying hair
...le and obvious as “going gray,?yet scientists have been unableto explain the precise cause of this usually...re is a major risk factor in the disease, whichhas been increasing in the past several decades.Melanocytes, which manufacture and store the pigment that com...Researchers identify target for cancer drugs
For nearly a decade, scientists have been trying to fully understand a particular communicat... have identified a component that researchers have been looking for since 1996," says Whitehead Associate Member David Sabatini, who is also an Assistant Pr...Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
...ow the physiological role of plant hemoglobins has been unclear. A group of researchers reveal this week that one such mysterious plant hemoglobin serves to assist in the fixation of nitrogen in the root nodules of legumes through a process that is conceptually not unlike that undertaken by mammalian hemo...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...le and obvious as “going gray,?yet scientists have been unableto explain the precise cause of this usually...re is a major risk factor in the disease, whichhas been increasing in the past several decades.Melanocytes, which manufacture and store the pigment that com...Scientists rid stem cell culture of key animal cells
...afety. However, not all the animal components have been removed from the media yet, but this is an important step." Working with three of WiCell's five human embryonic stem cell lines, Xu and his team explored the molecular interactions within the stem cell growth medium. He discovered that, in certain c...Essential mangrove forest threatened by cryptic ecological degradation
... magnitude of these modern irrigation projects has been such that entire river basins have been diverted to those of other rivers. Whereas these projects certainly develop the ability to grow crop...